salivary gland tumor

唾液腺腫瘍

WordNet

1. any of various organs that synthesize substances needed by the body and release it through ducts or directly into the bloodstream (同)secretory organ, secretor, secreter
2. a clear liquid secreted into the mouth by the salivary glands and mucous glands of the mouth; moistens the mouth and starts the digestion of starches (同)spit, spittle
3. of or relating to saliva; "salivary gland"
4. an abnormal new mass of tissue that serves no purpose (同)tumour, neoplasm

PrepTutorEJDIC

1. (生物体内の)腺(せん)
2. だ液,つば
3. だ液の;だ液を分泌する

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/10 15:20:05」(JST)

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Salivary gland cancer
The major salivary glands: the parotid gland (1), where most salivary gland tumors form, the submandibular gland (2), and the sublingual gland (3).
Classification and external resources
Specialty	Oncology
ICD-10	C07-C08, D11
ICD-9-CM	142, 210.2
MedlinePlus	001040
MeSH	D012468

Salivary gland cancer is a cancer that forms in tissues of a salivary gland. The salivary glands are classified as major and minor. The major salivary glands consist of the parotid, submandibular, and sublingual glands. The minor glands include small mucus-secreting glands located throughout the palate, nasal and oral cavity. Salivary gland cancer is rare, with 2% of head and neck tumors forming in the salivary glands, the majority in the parotid.

Classification

Due to diverse nature of salivary gland neoplasms, many different terms and classification systems have been used. Perhaps the most widely used currently is that system proposed by the World Health Organization in 2004, which classifies salivary neoplasms as primary or secondary, benign or malignant, and also by tissue of origin. This system defines five broad categories of salivary gland neoplasms:

• Malignant epithelial tumors
  • Acinic cell carcinoma
  • Mucoepidermoid carcinoma
  • Adenoid cystic carcinoma
  • Polymorphous low-grade adenocarcinoma
  • Epithelial-myoepithelial carcinoma
  • Clear cell carcinoma, not otherwise specified
  • Basal cell adenocarcinoma
  • Sebaceous carcinoma
  • Sebaceous lymphadenocarcinoma
  • Cystadenocarcinoma
  • Low-grade cribriform cystadenocarcinoma
  • Mucinous adenocarcinoma
  • Oncocytic carcinoma
  • Salivary duct carcinoma
  • Salivary duct carcinoma, not otherwise specified
  • Adenocarcinoma, not otherwise specified
  • Myoepithelial carcinoma
  • Carcinoma ex pleomorphic adenoma
  • Carcinosarcoma
  • Metastasizing pleomorphic adenoma
  • Squamous cell carcinoma
  • Large cell carcinoma
  • Lymphoepithelial carcinoma
  • Sialoblastoma
• Benign epithelial tumors
  • Pleomorphic adenoma
  • Myoepithelioma
  • Basal cell adenoma
  • Warthin's tumor
  • Oncocytoma
  • Canalicular adenoma
  • Lymphadenoma
    • Sebaceous lymphadenoma
    • Nonsebaceous lymphadenoma
  • Ductal papilloma
    • Inverted ductal papilloma
    • Intraductal papilloma
    • Sialadenoma papilliferum
  • Cystadenoma
• Soft tissue tumors
  • Hemangioma
• Hematolymphoid tumors
  • Hodgkin lymphoma
  • Diffuse large B-cell lymphoma
  • Extranodal marginal zone B cell lymphoma
• Secondary tumors (i.e. a tumor which has metastasized to the salivary gland from a distant location)

Others, not included in the WHO classification above, include:

• Intraosseous (central) salivary gland tumors
• Hybrid tumors (i.e. a tumor displaying combined forms of histologic tumor types)
  • Hybrid carcinoma
  • Others
• Others
  • Keratocystoma
  • Sialolipoma

Signs and symptoms

Benign tumor of the submandibular gland, also known as pleomorphic adenoma, presented as a painless neck mass in a 40-year-old man. At the left of the image is the white tumor with its characteristic cartilaginous cut surface. To the right is the normally lobated submandibular salivary gland.

Signs include fluid draining from the ear, pain, numbness, weakness, trouble swallowing, and a lump. The most common symptom of major salivary gland cancer is a painless lump in the affected gland, sometimes accompanied by paralysis of the facial nerve.

Causes

The chief risk factor is chewing tobacco, followed by smoking. Other risk factors include older age, radiation therapy treatment to head or neck, and being exposed to certain carcinogenic substances at work.

Diagnosis

In most cases, local excision with a margin of normal tissue is the appropriate form of biopsy for a major salivary gland tumor. In the parotid region, this requires identification of the facial nerve. For submandibular tumors, the entire submandibular triangle is cleared. In contrast, minor salivary gland tumors have a higher likelihood of being malignant, and an incisional biopsy is performed initially so that definitive treatment can be planned. In the parotid region, the presence of pain, recent rapid enlargement of a preexisting nodule, skin involvement, or facial nerve paralysis suggests cancer. Enlarged cervical lymph nodes in association with a salivary gland tumor are considered a manifestation of cancer until proved otherwise. Fine-needle aspiration is indicated if accurate diagnosis will allow for better treatment planning.

Prevention

Abstaining from smoking, chewing tobacco. Maintaining a diet high in fiber and green leafy vegetables. Change your toothbrush at regular intervals (weekly)

Treatment

Treatment may include the following:

• Surgery with or without radiation
• Radiotherapy

Fast neutron therapy has been used successfully to treat salivary gland tumors, and has shown to be significantly more effective than photons in studies treating unresectable salivary gland tumors.*Chemotherapy.

• Chemotherapy

Prognosis

Epidemiology

History

Tony Gwynn died of this.

See also

• Head and neck cancer
• Salivary gland pathology

References

External links

• Salivary gland cancer entry in the public domain NCI Dictionary of Cancer Terms
• Clinically reviewed salivary gland cancer for patients from Cancer Research UK.

 This article incorporates public domain material from the U.S. National Cancer Institute document "Dictionary of Cancer Terms".

UpToDate Contents

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• 1. 唾液腺腫瘍：疫学、診断、評価、および病期分類 salivary gland tumors epidemiology diagnosis evaluation and staging
• 2. 唾液腺腫瘍：限局性疾患の治療 salivary gland tumors treatment of locoregional disease
• 3. 悪性唾液腺腫瘍：再発性および転移性疾患の治療 malignant salivary gland tumors treatment of recurrent and metastatic disease
• 4. 頭頸部腫瘍の病理 pathology of head and neck neoplasms
• 5. 唾石症 salivary gland stones

English Journal

• Primary Pulmonary Salivary Gland-type Tumors: A Review and Update.

• Falk N1, Weissferdt A, Kalhor N, Moran CA.
• Advances in anatomic pathology.Adv Anat Pathol.2016 Jan;23(1):13-23. doi: 10.1097/PAP.0000000000000099.
• Pulmonary salivary gland-type tumors (SGT) comprise a very small proportion of primary lung neoplasms. The most common tumors among this group are mucoepidermoid carcinoma and adenoid cystic carcinoma. Contrary to the head and neck region, benign SGT such as pleomorphic adenomas are exceedingly rare
• PMID 26645458

• Mammary Analogue Secretory Carcinoma of Salivary Glands: Molecular Analysis of 25 ETV6 Gene Rearranged Tumors With Lack of Detection of Classical ETV6-NTRK3 Fusion Transcript by Standard RT-PCR: Report of 4 Cases Harboring ETV6-X Gene Fusion.

• Skálová A1, Vanecek T, Simpson RH, Laco J, Majewska H, Baneckova M, Steiner P, Michal M.
• The American journal of surgical pathology.Am J Surg Pathol.2016 Jan;40(1):3-13. doi: 10.1097/PAS.0000000000000537.
• ETV6 gene abnormalities are well described in tumor pathology. Many fusion partners of ETV6 have been reported in a variety of epithelial and hematological malignancies. In salivary gland tumor pathology, however, the ETV6-NTRK3 translocation is specific for mammary analogue secretory carcinoma (MAS
• PMID 26492182

• The role of aryl hydrocarbon receptor (AhR) in the pathology of pleomorphic adenoma in parotid gland.

• Drozdzik A1, Kowalczyk R2, Lipski M3, Łapczuk J4, Urasinska E5, Kurzawski M4.
• Archives of oral biology.Arch Oral Biol.2016 Jan;61:53-9. doi: 10.1016/j.archoralbio.2015.10.016. Epub 2015 Oct 22.
• OBJECTIVES: Pleomorphic adenoma (benign mixed tumor) is one of the most common salivary gland tumors. However, molecular mechanisms implicated in its development are not entirely defined. Therefore, the study aimed at definition of aryl hydrocarbon receptor (AhR) involvement in pleomorphic adenoma p
• PMID 26513682

Japanese Journal

• 原発性シェーグレン症候群に合併した気管原発悪性リンパ腫の1例

• 気管支学 38(3), 205-211, 2016
• NAID 130005156620

• Poorly differentiated salivary gland carcinoma with prominent squamous metaplasia in a pregnant Wistar Hannover rat

• Journal of Veterinary Medical Science 78(5), 859-862, 2016
• NAID 130005154294

• 左主気管支管状切除・端々吻合を行った唾液腺型肺癌の2例

• 日本呼吸器外科学会雑誌 30(4), 437-442, 2016
• NAID 130005150991

Related Links

• Salivary gland tumors: MedlinePlus Medical Encyclopedia

The most common type of salivary gland tumor is a slow-growing noncancerous (benign) tumor of the parotid gland. The tumor gradually increases the size of the gland. Some of these tumors can be cancerous (malignant). ...

• What Is Salivary Gland Cancer?

Salivary gland cancer starts in one of the salivary glands. It’s not just a single disease. There are actually several different salivary glands found inside and near your mouth. Many types of cancer and benign (non-cancerous) tumors ...

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★リンクテーブル★

リンク元	「唾液腺腫瘍」
関連記事	「tumor」「salivary」

「唾液腺腫瘍」

　　[★]

英

salivary gland neoplasm, salivary gland tumor, tumor of salivary gland, sialoma

関

唾液腺癌、唾液腺新生物、唾液腺、耳下腺腫瘍

「tumor」

　　[★]

• n.

• 腫瘍、腫瘤、腫脹

　

「salivary」

　　[★]

• 唾液の

関

saliva