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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/07/07 19:51:12」(JST)

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Salicylamide is the common name for the substance o-hydroxybenzamide, or amide of salicyl. Salicylamide is a non-prescription drug with analgesic and antipyretic properties. Its medicinal uses are similar to those of aspirin.^[1] Salicylamide is used in combination with both aspirin and caffeine in the over-the-counter pain remedy "PainAid". It was also an ingredient in the over-the-counter pain remedy BC Powder but was removed from the formulation in 2009.

Pure Salicylamide is a white or slightly pink crystalline powder

References

^ salicylamide. Dictionary.com. Merriam-Webster's Medical Dictionary. Merriam-Webster, Inc. [1] (accessed: December 31, 2006).

External links

Safety MSDS data

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UpToDate Contents

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1. 駆虫薬療法 anthelminthic therapies
2. 抗原虫治療 antiprotozoal therapies
3. 鎮痛剤による慢性腎臓病 analgesic related chronic kidney disease
4. ジアルジア症の治療および予防 treatment and prevention of giardiasis

English Journal

Structure-activity studies of Wnt/β-catenin inhibition in the Niclosamide chemotype: Identification of derivatives with improved drug exposure.

Mook RA Jr1, Wang J2, Ren XR2, Chen M2, Spasojevic I3, Barak LS4, Lyerly HK5, Chen W6.
Bioorganic & medicinal chemistry.Bioorg Med Chem.2015 Sep 1;23(17):5829-38. doi: 10.1016/j.bmc.2015.07.001. Epub 2015 Aug 10.
The Wnt signaling pathway plays a key role in regulation of organ development and tissue homeostasis. Dysregulated Wnt activity is one of the major underlying mechanisms responsible for many diseases including cancer. We previously reported the FDA-approved anthelmintic drug Niclosamide inhibits Wnt
PMID 26272032

Synthesis and fungicidal activity of N-thiazol-4-yl-salicylamides, a new family of anti-oomycete compounds.

Sulzer-Mosse S1, Cederbaum F1, Lamberth C2, Berthon G1, Umarye J3, Grasso V1, Schlereth A1, Blum M1, Waldmeier R1.
Bioorganic & medicinal chemistry.Bioorg Med Chem.2015 May 1;23(9):2129-38. doi: 10.1016/j.bmc.2015.03.007. Epub 2015 Mar 10.
A novel class of experimental fungicides has been discovered, which consists of special N-thiazol-4-yl-salicylamides. They originated from amide reversion of lead structures from the patent literature and are highly active against important phytopathogens, such as Phytophthora infestans (potato and
PMID 25801153

Specific aromatic foldamers potently inhibit spontaneous and seeded Aβ42 and Aβ43 fibril assembly.

Seither KM1, McMahon HA1, Singh N1, Wang H1, Cushman-Nick M, Montalvo GL, DeGrado WF2, Shorter J.
The Biochemical journal.Biochem J.2014 Nov 15;464(1):85-98. doi: 10.1042/BJ20131609.
Amyloid fibrils are self-propagating entities that spread pathology in several devastating disorders including Alzheimer's disease (AD). In AD, amyloid-β (Aβ) peptides form extracellular plaques that contribute to cognitive decline. One potential therapeutic strategy is to develop inhibitors that
PMID 25142005

Japanese Journal

Geometric Selectivity, Hydrogen-Bonding Interaction, and Solvatochromism of Bis{N-(aminoalkyl)salicylamidato(2-)}cobaltate(III)

, , ,
Chemistry Letters 40(7), 696-698, 2011
… Cobalt(III) complexes with N-(aminoalkyl)salicylamide dianions, Ln2− (n = 1–4), have been prepared and their molecular and crystal structures have been determined. …
NAID 130004426261

JBIR-58, a new salicylamide derivative, isolated from a marine sponge-derived Streptomyces sp. SpD081030ME-02

UEDA Jun-ya,KHAN Shams Tabrez,TAKAGI Motoki,SHIN-YA Kazuo
Journal of antibiotics 63(5), 267-269, 2010-05-25
NAID 10030708487

小麦依存性サリチル酸誘発アナフィラキシーと考えられた１例

山岡明子,小田島安平
日本小児アレルギー学会誌 23(3), 295-302, 2009
14歳，男児．PL顆粒やイブプロフェンとうどんの同時摂取で蕁麻疹やアナフィラキシーの既往がある．2008年2月に学校で給食を摂取した後にサッカーをしていたところアナフィラキシーが出現した．給食は牛乳，おでん（大根・卵・はんぺん・コンニャク・人参・ほうれん草・ちくわ），わかめご飯，魚フライであった．小麦，グルテンの血中抗原特異的IgE抗体（ImmunoCAP<SUP>®</SUP …
NAID 130004852156

「サリチルアミド」

Salicylamide
Systematic (IUPAC) name
	2-hydroxybenzamide
Clinical data
MedlinePlus	a681004
Legal status	?
Pharmacokinetic data
Excretion	Renal
Identifiers
CAS number	65-45-2
ATC code	N02BA05; N02BA55 (combinations)
PubChem	CID 5147
DrugBank	DB08797
ChemSpider	4963
UNII	EM8BM710ZC
ChEBI	CHEBI:32114
ChEMBL	CHEMBL27577
NIAID ChemDB	018403
Chemical data
Formula	C7H7NO2
Mol. mass	137.136 g/mol
	SMILES O=C(c1ccccc1O)N;
	InChI InChI=1S/C7H7NO2/c8-7(10)5-3-1-2-4-6(5)9/h1-4,9H,(H2,8,10) ; Key:SKZKKFZAGNVIMN-UHFFFAOYSA-N ;
Physical data
Density	1.33 g/cm³
Solubility in water	Soluble in hot water, ether, alcohol, and chloroform. mg/mL (20 °C)
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