WordNet

a sudden occurrence (or recurrence) of a disease; "he suffered an epileptic seizure" (同)ictus, raptus
the taking possession of something by legal process
of or relating to or characterizing mental events that have motor consequences or vice versa

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〈U〉〈C〉つかむ(つかまれる)こと / 〈U〉〈C〉強奪;差し押さえ;逮捕 / 〈C〉(病気・恐怖などが)襲うこと,発作

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1. 小児痙攣およびてんかんの分類、病因、および臨床的特徴の概要 overview of the classification etiology and clinical features of pediatric seizures and epilepsy
2. 成人における初回痙攣発作の評価 evaluation of the first seizure in adults
3. 成人におけるてんかんのマネージメントの概要 overview of the management of epilepsy in adults
4. 局在関連（部分）てんかん：原因および臨床的特徴 localization related partial epilepsy causes and clinical features
5. 高齢患者における痙攣発作およびてんかん：病因、臨床像、および診断 seizures and epilepsy in the elderly patient etiology clinical presentation and diagnosis

English Journal

Mitochondrial DNA profiling via genomic analysis in mesial temporal lobe epilepsy patients with hippocampal sclerosis.

Gurses C1, Azakli H2, Alptekin A3, Cakiris A2, Abaci N2, Arikan M2, Kursun O3, Gokyigit A4, Ustek D5.Author information 1Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. Electronic address: candangrss@gmail.com.2Genetics, Institute for Experimental Medicine, Istanbul University, Istanbul, Turkey.3Computer Engineering, Istanbul University, Istanbul, Turkey.4Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.5Genetics, Institute for Experimental Medicine, Istanbul University, Istanbul, Turkey. Electronic address: dustek@istanbul.edu.tr.AbstractINTRODUCTION: Mitochondria have an essential role in neuronal excitability and neuronal survival. In addition to energy production, mitochondria also play a crucial role in the maintenance of intracellular calcium homeostasis, generation of reactive oxygen species and mechanisms of cell death. There is a relative paucity of data about the role of mitochondria in epilepsy. Mitochondrial genome analysis is rarely carried out in the investigation of some diseases. In mesial temporal lobe epilepsies (MTLE) cases, genome analysis has never been used previously. The aim of this study is to show mitochondrial dysfunctions using genome analysis in patients with MTLE-hippocampal sclerosis (HS).
Gene.Gene.2014 Apr 1;538(2):323-7. doi: 10.1016/j.gene.2014.01.030. Epub 2014 Jan 16.
INTRODUCTION: Mitochondria have an essential role in neuronal excitability and neuronal survival. In addition to energy production, mitochondria also play a crucial role in the maintenance of intracellular calcium homeostasis, generation of reactive oxygen species and mechanisms of cell death. There
PMID 24440288

Expression of β‑amyloid precursor protein in refractory epilepsy.

Sima X1, Xu J1, Li J2, Zhong W1, You C1.Author information 1Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, P.R. China.2Department of Neurology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, P.R. China.Abstractβ‑amyloid precursor protein (β‑APP), also known as Aβ peptide, has a key role in the pathogenesis of Alzheimer's disease, and is also likely to be involved in the development of refractory epilepsy. The mechanism behind the association between β‑APP and refractory epilepsy remains to be elucidated. The aim of the present study was to examine the levels of APP mRNA and β‑APP protein in patients with refractory epilepsy. Tissue samples were obtained from patients with chronic pharmacoresistant epilepsy who underwent surgery. Levels of APP mRNA and β‑APP protein in epileptic temporal lobe and hippocampal tissue were assessed using quantitative polymerase chain reaction, immunohistochemistry and immunofluorescence. The expression levels of protein significantly increased in the temporal cortex and the hippocampus of the patients with epilepsy. β‑APP may thus contribute to the pathogenesis of refractory epilepsy.
Molecular medicine reports.Mol Med Rep.2014 Apr;9(4):1242-8. doi: 10.3892/mmr.2014.1977. Epub 2014 Feb 21.
β‑amyloid precursor protein (β‑APP), also known as Aβ peptide, has a key role in the pathogenesis of Alzheimer's disease, and is also likely to be involved in the development of refractory epilepsy. The mechanism behind the association between β‑APP and refractory epilepsy remains to be el
PMID 24566726

Impaired cognitive ability and anxiety-like behavior following acute seizures in the Theiler's virus model of temporal lobe epilepsy.

Umpierre AD1, Remigio GJ1, Dahle EJ2, Bradford K2, Alex AB3, Smith MD4, West PJ5, White HS5, Wilcox KS6.Author information 1Interdepartmental Program in Neuroscience, University of Utah, 1401 MREB, 20 North 1900 East, Salt Lake City, UT 84132.2Department of Pharmacology and Toxicology, University of Utah.3Anticonvulsant Drug Development Program, University of Utah, 417 Wakara Way, Suite 3211, Salt Lake City, UT 84108, USA.4Department of Pharmacology and Toxicology, University of Utah; Anticonvulsant Drug Development Program, University of Utah, 417 Wakara Way, Suite 3211, Salt Lake City, UT 84108, USA.5Interdepartmental Program in Neuroscience, University of Utah, 1401 MREB, 20 North 1900 East, Salt Lake City, UT 84132; Department of Pharmacology and Toxicology, University of Utah; Anticonvulsant Drug Development Program, University of Utah, 417 Wakara Way, Suite 3211, Salt Lake City, UT 84108, USA.6Interdepartmental Program in Neuroscience, University of Utah, 1401 MREB, 20 North 1900 East, Salt Lake City, UT 84132; Department of Pharmacology and Toxicology, University of Utah; Anticonvulsant Drug Development Program, University of Utah, 417 Wakara Way, Suite 3211, Salt Lake City, UT 84108, USA. Electronic address: karen.wilcox@hsc.utah.edu.AbstractViral infection of the CNS can result in encephalitis and acute seizures, increasing the risk for later-life epilepsy. We have previously characterized a novel animal model of temporal lobe epilepsy that recapitulates key sequela in the development of epilepsy following viral infection. C57BL/6J mice inoculated with the Daniel's strain of Theiler's Murine Encephalomyelitis Virus (TMEV; 3×10(5) PFU, i.c.) display acute limbic seizures that secondarily generalize. A majority of acutely seized animals develop spontaneous seizures weeks to months later. As part of our investigation, we sought to assess behavioral comorbidity following TMEV inoculation. Anxiety, depression, cognitive impairment, and certain psychoses are diagnosed in persons with epilepsy at rates far more frequent than in the general population. We used a battery of behavioral tests to assess anxiety, depression, cognitive impairment, and general health in acutely seized animals inoculated with TMEV and compared behavioral outcomes against age-matched controls receiving a sham injection. We determined that TMEV-seized animals are less likely to move through the exposed center of an open field and are less likely to enter into the lighted half of a light/dark box; both behaviors may be indicative of anxiety-like behavior. TMEV-seized animals also display early and persistent reductions in novel object exploration during novel object place tasks and do not improve in their ability to find a hidden escape platform in Morris water maze testing, indicative of impairment in episodic and spatial memory, respectively. Cresyl violet staining at 35 and 250 days after injection reveals bilateral reductions in hippocampal area, with extensive sclerosis of CA1 evident bilaterally along the rostral-caudal axis. Early and persistent behavioral changes in the TMEV model provide surrogate markers for assessing disease progression as well as endpoints in screening for the efficacy of novel compounds to manage both seizure burden and comorbid conditions.
Neurobiology of disease.Neurobiol Dis.2014 Apr;64:98-106. doi: 10.1016/j.nbd.2013.12.015. Epub 2014 Jan 9.
Viral infection of the CNS can result in encephalitis and acute seizures, increasing the risk for later-life epilepsy. We have previously characterized a novel animal model of temporal lobe epilepsy that recapitulates key sequela in the development of epilepsy following viral infection. C57BL/6J mic
PMID 24412221