- 関
- CD59
- 同
- CD59
- 関
- CD59
WordNet
- shielding (or designed to shield) against harm or discomfort; "the protecting blanket of snow"; "a protecting alibi"
- use tariffs to favor domestic industry
- shield from danger, injury, destruction, or damage; "Weatherbeater protects your roof from the rain"
PrepTutorEJDIC
- (危険・損害などから)…‘を'『守る』,『保護する』《+『名』+『from』(『against』)+『名』(do『ing』)》 / 〈国内産業〉‘を'保護する
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/02/09 23:58:37」(JST)
[Wiki en表示]
CD59 |
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Available structures |
PDB |
Ortholog search: PDBe RCSB |
List of PDB id codes |
1CDQ, 1CDR, 1CDS, 1ERG, 1ERH, 2J8B, 2OFS, 2UWR, 2UX2, 4BIK
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Identifiers |
Aliases |
CD59, 16.3A5, 1F5, EJ16, EJ30, EL32, G344, HRF-20, HRF20, MAC-IP, MACIF, MEM43, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, p18-20, CD59 molecule |
External IDs |
OMIM: 107271 MGI: 1888996 HomoloGene: 56386 GeneCards: CD59 |
Gene ontology |
Molecular function |
• protein binding
• complement binding
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Cellular component |
• vesicle
• endoplasmic reticulum membrane
• membrane
• focal adhesion
• Golgi membrane
• plasma membrane
• extracellular region
• cell surface
• compact myelin
• anchored component of external side of plasma membrane
• ER to Golgi transport vesicle membrane
• anchored component of membrane
• sarcolemma
• extracellular exosome
• endoplasmic reticulum-Golgi intermediate compartment membrane
• extracellular space
• specific granule membrane
• tertiary granule membrane
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Biological process |
• blood coagulation
• negative regulation of apoptotic process
• negative regulation of activation of membrane attack complex
• ER to Golgi vesicle-mediated transport
• cell surface receptor signaling pathway
• COPII vesicle coating
• positive regulation of T cell proliferation
• regulation of complement activation
• cell activation
• neutrophil degranulation
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Sources:Amigo / QuickGO |
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RNA expression pattern |
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More reference expression data |
Orthologs |
Species |
Human |
Mouse |
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
NM_203331
NM_000611
NM_001127223
NM_001127225
NM_001127226
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NM_001127227
NM_203329
NM_203330
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RefSeq (protein) |
NP_000602
NP_001120695
NP_001120697
NP_001120698
NP_001120699
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NP_976074
NP_976075
NP_976076
NP_000602.1
NP_001120695.1
NP_001120697.1
NP_001120698.1
NP_001120699.1
NP_976074.1
NP_976075.1
NP_976076.1
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Location (UCSC) |
Chr 11: 33.7 – 33.74 Mb |
Chr 2: 104.07 – 104.09 Mb |
PubMed search |
[1] |
[2] |
Wikidata |
View/Edit Human |
View/Edit Mouse |
CD59 glycoprotein also known as MAC-inhibitory protein (MAC-IP), membrane inhibitor of reactive lysis (MIRL), or protectin, is a protein that in humans is encoded by the CD59 gene.[3] It belongs to the LY6/uPAR/alpha-neurotoxin protein family.[4]
CD59 attaches to host cells via a glycophosphatidylinositol (GPI) anchor. When complement activation leads to deposition of C5b678 on host cells, CD59 can prevent C9 from polymerizing and forming the complement membrane attack complex.[5] It may also signal the cell to perform active measures such as endocytosis of the CD59-CD9 complex.[4]
Mutations affecting GPI that reduce expression of CD59 and decay-accelerating factor on red blood cells result in paroxysmal nocturnal hemoglobinuria.[6]
Viruses such as HIV, human cytomegalovirus and vaccinia incorporate host cell CD59 into their own viral envelope to prevent lysis by complement.[7]
References
- ^ "Human PubMed Reference:".
- ^ "Mouse PubMed Reference:".
- ^ "Entrez Gene: CD59 molecule, complement regulatory protein".
- ^ a b Maio M, Brasoveanu LI, Coral S, Sigalotti L, Lamaj E, Gasparollo A, Visintin A, Altomonte M, Fonsatti E (Aug 1998). "Structure, distribution, and functional role of protectin (CD59) in complement-susceptibility and in immunotherapy of human malignancies (Review)". international journal of oncology. 13 (2): 305–18. doi:10.3892/ijo.13.2.305. PMID 9664126.
- ^ Huang Y, Qiao F, Abagyan R, Hazard S, Tomlinson S (September 2006). "Defining the CD59-C9 binding interaction". J. Biol. Chem. 281 (37): 27398–27404. doi:10.1074/jbc.M603690200. PMID 16844690.
- ^ Parker C, Omine M, Richards S, et al. (2005). "Diagnosis and management of paroxysmal nocturnal hemoglobinuria". Blood. 106 (12): 3699–709. doi:10.1182/blood-2005-04-1717. PMC 1895106. PMID 16051736.
- ^ Bohana-Kashtan O, Ziporen L, Donin N, Kraus S, Fishelson Z (July 2004). "Cell signals transduced by complement". Mol. Immunol. 41 (6–7): 583–597. doi:10.1016/j.molimm.2004.04.007. PMID 15219997.
Further reading
- Tandon N, Morgan BP, Weetman AP (1992). "Expression and function of membrane attack complex inhibitory proteins on thyroid follicular cells". Immunology. 75 (2): 372–7. PMC 1384722. PMID 1372592.
- Holmes CH, Simpson KL, Okada H, et al. (1992). "Complement regulatory proteins at the feto-maternal interface during human placental development: distribution of CD59 by comparison with membrane cofactor protein (CD46) and decay accelerating factor (CD55)". Eur. J. Immunol. 22 (6): 1579–1585. doi:10.1002/eji.1830220635. PMID 1376264.
- Hahn WC, Menu E, Bothwell AL, et al. (1992). "Overlapping but nonidentical binding sites on CD2 for CD58 and a second ligand CD59". Science. 256 (5065): 1805–1807. doi:10.1126/science.1377404. PMID 1377404.
- Ninomiya H, Sims PJ (1992). "The human complement regulatory protein CD59 binds to the alpha-chain of C8 and to the "b"domain of C9". J. Biol. Chem. 267 (19): 13675–80. PMID 1377690.
- Petranka JG, Fleenor DE, Sykes K, et al. (1992). "Structure of the CD59-encoding gene: further evidence of a relationship to murine lymphocyte antigen Ly-6 protein". Proc. Natl. Acad. Sci. U.S.A. 89 (17): 7876–7879. doi:10.1073/pnas.89.17.7876. PMC 49817. PMID 1381503.
- Motoyama N, Okada N, Yamashina M, Okada H (1992). "Paroxysmal nocturnal hemoglobinuria due to hereditary nucleotide deletion in the HRF20 (CD59) gene". Eur. J. Immunol. 22 (10): 2669–2673. doi:10.1002/eji.1830221029. PMID 1382994.
- Rooney IA, Morgan BP (1992). "Characterization of the membrane attack complex inhibitory protein CD59 antigen on human amniotic cells and in amniotic fluid". Immunology. 76 (4): 541–7. PMC 1421564. PMID 1383132.
- Tone M, Walsh LA, Waldmann H (1992). "Gene structure of human CD59 and demonstration that discrete mRNAs are generated by alternative polyadenylation". J. Mol. Biol. 227 (3): 971–976. doi:10.1016/0022-2836(92)90239-G. PMID 1383553.
- Philbrick WM, Palfree RG, Maher SE, et al. (1990). "The CD59 antigen is a structural homologue of murine Ly-6 antigens but lacks interferon inducibility". Eur. J. Immunol. 20 (1): 87–92. doi:10.1002/eji.1830200113. PMID 1689664.
- Sawada R, Ohashi K, Anaguchi H, et al. (1990). "Isolation and expression of the full-length cDNA encoding CD59 antigen of human lymphocytes". DNA Cell Biol. 9 (3): 213–220. doi:10.1089/dna.1990.9.213. PMID 1692709.
- Yamashina M, Ueda E, Kinoshita T, et al. (1990). "Inherited complete deficiency of 20-kilodalton homologous restriction factor (CD59) as a cause of paroxysmal nocturnal hemoglobinuria". N. Engl. J. Med. 323 (17): 1184–1189. doi:10.1056/NEJM199010253231707. PMID 1699124.
- Rooney IA, Morgan BP (1991). "Protection of human amniotic epithelial cells (HAEC) from complement-mediated lysis: expression on the cells of three complement inhibitory membrane proteins". Immunology. 71 (3): 308–11. PMC 1384423. PMID 1702747.
- Watts MJ, Dankert JR, Morgan EP (1990). "Isolation and characterization of a membrane-attack-complex-inhibiting protein present in human serum and other biological fluids". Biochem. J. 265 (2): 471–7. PMC 1136908. PMID 2302178.
- Okada H, Nagami Y, Takahashi K, et al. (1989). "20 KDa homologous restriction factor of complement resembles T cell activating protein". Biochem. Biophys. Res. Commun. 162 (3): 1553–1559. doi:10.1016/0006-291X(89)90852-8. PMID 2475111.
- Davies A, Simmons DL, Hale G, et al. (1989). "CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells". J. Exp. Med. 170 (3): 637–654. doi:10.1084/jem.170.3.637. PMC 2189447. PMID 2475570.
- Sawada R, Ohashi K, Okano K, et al. (1989). "Complementary DNA sequence and deduced peptide sequence for CD59/MEM-43 antigen, the human homologue of murine lymphocyte antigen Ly-6C". Nucleic Acids Res. 17 (16): 6728–6728. doi:10.1093/nar/17.16.6728. PMC 318369. PMID 2476718.
- Sugita Y, Tobe T, Oda E, et al. (1990). "Molecular cloning and characterization of MACIF, an inhibitor of membrane channel formation of complement". J. Biochem. 106 (4): 555–7. PMID 2606909.
- Bora NS, Gobleman CL, Atkinson JP, et al. (1994). "Differential expression of the complement regulatory proteins in the human eye". Invest. Ophthalmol. Vis. Sci. 34 (13): 3579–84. PMID 7505007.
- Kieffer B, Driscoll PC, Campbell ID, et al. (1994). "Three-dimensional solution structure of the extracellular region of the complement regulatory protein CD59, a new cell-surface protein domain related to snake venom neurotoxins". Biochemistry. 33 (15): 4471–4482. doi:10.1021/bi00181a006. PMID 7512825.
- Kennedy SP, Rollins SA, Burton WV, et al. (1994). "Protection of porcine aortic endothelial cells from complement-mediated cell lysis and activation by recombinant human CD59". Transplantation. 57 (10): 1494–501. doi:10.1097/00007890-199405000-00017. PMID 7515200.
External links
- CD59 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
PDB gallery
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1cdq: STRUCTURE OF A SOLUBLE, GLYCOSYLATED FORM OF THE HUMAN COMPLEMENT REGULATORY PROTEIN CD59
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1cdr: STRUCTURE OF A SOLUBLE, GLYCOSYLATED FORM OF THE HUMAN COMPLEMENT REGULATORY PROTEIN CD59
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1cds: STRUCTURE OF A SOLUBLE, GLYCOSYLATED FORM OF THE HUMAN COMPLEMENT REGULATORY PROTEIN CD59
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1erg: THREE-DIMENSIONAL SOLUTION STRUCTURE OF THE EXTRACELLULAR REGION OF THE COMPLEMENT REGULATORY PROTEIN, CD59, A NEW CELL SURFACE PROTEIN DOMAIN RELATED TO NEUROTOXINS
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1erh: THREE-DIMENSIONAL SOLUTION STRUCTURE OF THE EXTRACELLULAR REGION OF THE COMPLEMENT REGULATORY PROTEIN, CD59, A NEW CELL SURFACE PROTEIN DOMAIN RELATED TO NEUROTOXINS
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2ofs: Crystal structure of human CD59
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Proteins: complement system (C, L, A)
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Activators/enzymes |
Early |
- A: Factor B
- Factor D
- Factor P/Properdin
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Middle |
- C3-convertase
- C5-convertase
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Late |
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Inhibitors |
- CLA: C1-inhibitor
- Decay-accelerating factor/CD59
- Factor I
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Complement receptors |
- CR1
- CR2
- CR3
- CR4
- CD11b/CD11c/CD18
- Anaphylatoxin
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UpToDate Contents
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English Journal
- Pro-Resolving Lipid Mediators Improve Neuronal Survival and Increase Aβ42 Phagocytosis.
- Zhu M1,2, Wang X1,3, Hjorth E1, Colas RA4, Schroeder L1, Granholm AC5, Serhan CN4, Schultzberg M6.
- Molecular neurobiology.Mol Neurobiol.2015 Dec 9. [Epub ahead of print]
- Inflammation in the brain is a prominent feature in Alzheimer's disease (AD). Recent studies suggest that chronic inflammation can be a consequence of failure to resolve the inflammation. Resolution of inflammation is mediated by a family of lipid mediators (LMs), and the levels of these specialized
- PMID 26650044
- Human Periodontal Stem Cells Release Specialized Proresolving Mediators and Carry Immunomodulatory and Prohealing Properties Regulated by Lipoxins.
- Cianci E1, Recchiuti A2, Trubiani O3, Diomede F3, Marchisio M1, Miscia S1, Colas RA4, Dalli J4, Serhan CN4, Romano M5.
- Stem cells translational medicine.Stem Cells Transl Med.2015 Nov 25. pii: sctm.2015-0163. [Epub ahead of print]
- : Unresolved inflammation and tissue destruction are underlying mechanisms of periodontitis, which is linked to dysregulated polymorphonuclear neutrophil (PMN) functions. Lipoxin A4 (LXA4) is a specialized proresolving lipid mediator (SPM) that dampens excessive inflammation, promotes resolution, an
- PMID 26607175
- Synthesis of the 16S,17S-Epoxyprotectin Intermediate in the Biosynthesis of Protectins by Human Macrophages.
- Aursnes M1, Tungen JE1, Colas RA2, Vlasakov I2, Dalli J2, Serhan CN2, Hansen TV1.
- Journal of natural products.J Nat Prod.2015 Nov 18. [Epub ahead of print]
- The n-3 polyunsaturated fatty acids act as substrates during the resolution phase of acute inflammation for the biosynthesis of specialized pro-resolving lipid mediators. One premier example is the C22-dihydroxy-polyunsaturated fatty acid protectin D1 (1). The human 15-lipoxygenase type I, via stere
- PMID 26580578
Japanese Journal
- Role of omega-3 fatty acids and their metabolites in asthma and allergic diseases
- Miyata Jun,Arita Makoto
- Allergology International 64(1), 27-34, 2015
- Omega-3 fatty acids, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), are found naturally in fish oil and are commonly thought to be anti-inflammatory nutrients, with protective effects in …
- NAID 130004873127
- アレルギーの発症と抗炎症性脂質メディエーター (特集 アレルギーの発症への関与因子)
- D-10-4 ESD入力保護能力を低下させないIC間断線の電気的検査用回路(D-10.ディペンダブルコンピューテイング,一般セッション)
- 小西 朝陽,四柳 浩之,橋爪 正樹
- 電子情報通信学会総合大会講演論文集 2012年_情報・システム(1), 179, 2012-03-06
- NAID 110009461352
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★リンクテーブル★
[★]
- 同
- protectin
-HRF
- 同
- homologous restriction factor
- 同
- Complement protein; Membrane inhib- itor reactive lysis; Homologous restriction factor 20
- 同
- protectin
[★]
- 関
- concealing coloration、crypsis、cryptic color、protective coloration
[★]
- 関
- conservation、conserve、guardian、protection、safeguard