WordNet

the 8th letter of the Roman alphabet (同)h
a potent substance that acts like a hormone and is found in many bodily tissues (and especially in semen); produced in response to trauma and may affect blood pressure and metabolism and smooth muscle activity

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/04/22 15:23:37」(JST)

Prostaglandin H2, a type of prostaglandin derived from arachidonic acid,is a precursor for many other biologically significant molecules.

Eicosanoid synthesis - prostaglandin H2 near center

It is acted upon by:

Figure 1: Synthetic pathways from PGH₂ (the parent compound) to prostaglandins, prostacyclin and thromboxanes

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Kupffer cell depletion attenuates leptin-mediated methoxamine-stimulated portal perfusion pressure and thromboxane A2 release in a rodent model of NASH-cirrhosis.

Yang YY, Huang YT, Tsai TH, Hou MC, Lee FY, Lee SD, Lin HC.SourceDepartment of Medicine, Taipei Veterans General Hospital, Taiwan. yyyang@vghtpe.gov.tw
Clinical science (London, England : 1979).Clin Sci (Lond).2012 Dec;123(12):669-80. doi: 10.1042/CS20110572.
Cirrhotic portal hypertension is characterized by increased hepatic oxidative stress, AA (arachidonic acid)-derived TXA(2) (thromboxane A(2)) release and exaggerated hepatic response to the α-adrenergic agonist MTX (methoxamine). Besides promoting hepatic fibrosis, the role of hyperleptinaemia in t
PMID 22734967

High-precision, room temperature screening assay for inhibitors of microsomal prostaglandin E synthase-1.

Andersson S, Norman M, Olsson R, Smith R, Liu G, Nord J.SourceAstraZeneca, CNS/Pain iMED, Department of Neuroscience, Södertälje, Sweden.
Journal of biomolecular screening.J Biomol Screen.2012 Dec;17(10):1372-8. doi: 10.1177/1087057112456424. Epub 2012 Aug 15.
Microsomal prostaglandin E synthase-1 (mPGES-1) is the major enzyme catalyzing the isomerization of prostaglandin (PG) H(2) to PGE(2). Here we report the development of a robust and practical automated assay in a 384-well format for room temperature screening of mPGES-1 inhibitors with high precisio
PMID 22895459

Regional Differences in the Neuronal Expression of Cyclooxygenase-2 (COX-2) in the Newborn Pig Brain

Oláh Orsolya,Németh István,Tóth-Szuki Valéria,Bari Ferenc,Domoki Ferenc
ACTA HISTOCHEMICA ET CYTOCHEMICA 45(3), 187-192, 2012
Cyclooxygenase (COX)-2 is the major constitutively expressed COX isoform in the newborn brain. COX-2 derived prostanoids and reactive oxygen species appear to play a major role in the mechanism of per …
NAID 130001854244

NSAIDs潰瘍の予防・治療における抗潰瘍薬の位置づけ抗潰瘍薬選択のポイントとその留意点 (特集 NSAIDs潰瘍--最新の予防・治療) -- (NSAIDs潰瘍の予防・治療戦略)

拡張検索	「prostaglandin H2-thromboxane A2 receptor」「prostaglandin H2 receptor」
関連記事	「H」「prostaglandin」「prostaglandins」

Prostaglandin H2
Identifiers
CAS number	42935-17-1
PubChem	445049
ChemSpider	392800
MeSH	Prostaglandin+H2
ChEBI	CHEBI:15554
Jmol-3D images	Image 1
	SMILES O=C(O)CCC/C=C\C[C@H]2[C@H]1OO[C@H](C1)[C@@H]2/C=C/[C@@H](O)CCCCC ;
	InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 ; Key: YIBNHAJFJUQSRA-YNNPMVKQSA-N InChI=1/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1; Key: YIBNHAJFJUQSRA-YNNPMVKQBN ;
Properties
Molecular formula	C20H32O5
Molar mass	352.465 g/mol
	Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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	Infobox references