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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/07/28 05:36:52」(JST)

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Propyphenazone is a derivative of phenazone^[1] with similar analgesic and antipyretic effects.

Adverse Effects of Propyphenazone[edit]

There have been case reports describing risk of Acute inferior myocardial infarction with low atrial rhythm due to propyphenazone: Kounis syndrome.^[2]^{[citation needed]}

Countries that have banned Propyphenazone[edit]

“WHO Comment : Propyphenazone, a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, was introduced in 1951 for the treatment of rheumatic disorders. As it is structurally related to aminophenazone it has been associated with severe blood dyscrasias. However, it cannot be transformed into potentially carcinogenic nitrosamines and has therefore been widely used as a replacement drug for aminophenazone. In certain countries, products containing propyphenazone have now been restricted in their indications, whereas in others they are still available, sometimes as over-the-counter preparations.” ^[3]

Sri Lanka ^[4]

Korea ^[4]

“SEOUL - Amid rising claims that it isn't moving fast enough to counter public concern over the safety of OTC painkillers, Korea FDA has banned Bayer Korea's painkiller Saridon-A, Samjin Pharm's Geworin and 26 other products from being prescribed or sold over the counter to those under 15 years of age”^[5]

Malaysia ^[4]
Thailand ^[4]
Turkey: Banned for Production and sale Jan. 1986 having regard to severe adverse reaction. ^[3]

References[edit]

^ Göres, E.; Kossowicz, J.; Schneider, H. G. (2004). [Propyphenazone. Pharmacology and use] |trans-title= requires |title= (help). Medizinische Monatsschrift für Pharmazeuten (in German) 27 (3): 72–76. PMID 15032249. edit
^ Akyel, A.; Alsancak, Y.; Yayla, Ç. R.; Şahinarslan, A.; Özdemir, M. (2011). "Acute inferior myocardial infarction with low atrial rhythm due to propyphenazone: Kounis syndrome". International Journal of Cardiology 148 (3): 352–353. doi:10.1016/j.ijcard.2010.05.038. PMID 20541820. edit
^ ^a ^b Consolidated List of Products whose Consumption and/or Sale have been Banned, Withdrawn, Severely Restricted or not Approved by Governments, Twelfth Issue (pdf). New York: Department of Economic and Social Affairs of the United Nations Secretariat. 2005. p. 232.
^ ^a ^b ^c ^d "Multi-Country Survey On Banned And Restricted Pharmaceuticals". Health Action International Asia Pacific. August 2008. p. 7. Missing or empty |url= (help)
^ "Bayer’s Saridon-A Among 28 Painkillers Banned To Those Under 15 In Korea". PharmAsia News. 2009-03-12.

This analgesic-related article is a stub. You can help Wikipedia by expanding it.

English Journal

Green chromatography separation of analytes of greatly differing properties using a polyethylene glycol stationary phase and a low-toxic water-based mobile phase.

Šatínský D, Brabcová I, Maroušková A, Chocholouš P, Solich P.SourceDepartment of Analytical Chemistry, Faculty of Pharmacy, Charles University, Heyrovského 1203, Hradec Králové, 500 05, Czech Republic. satinsky@faf.cuni.cz
Analytical and bioanalytical chemistry.Anal Bioanal Chem.2013 Jul;405(18):6105-15. doi: 10.1007/s00216-013-7003-1. Epub 2013 May 9.
A simple, rapid, and environmentally friendly HPLC method was developed and validated for the separation of four compounds (4-aminophenol, caffeine, paracetamol, and propyphenazone) with different chemical properties. A "green" mobile phase, employing water as the major eluent, was proposed and appl
PMID 23657456

[Rapid identification 15 effective components of anti common cold medicine with MRM by LC-MS/MS].

Jiang JG, Zhang XR, Zhang YH, Song GS.SourceHebei Institute for Food and Drug Control, Shijiazhuang 050011, China.
Yao xue xue bao = Acta pharmaceutica Sinica.Yao Xue Xue Bao.2013 Jan;48(1):94-7.
This paper reports the establishment of a method for rapid identification 15 effective components of anti common cold medicine (paracetamol, aminophenazone, pseudoephedrine hydrochloride, methylephedrine hydrochloride, caffeine, amantadine hydrochloride, phenazone, guaifenesin, chlorphenamine maleat
PMID 23600148

Occurrence and distribution of multi-class pharmaceuticals and their active metabolites and transformation products in the Ebro river basin (NE Spain).

López-Serna R, Petrović M, Barceló D.SourceDepartment of Environmental Chemistry, IDAEA-CSIC, C/Jordi Girona 18-26, 08034 Barcelona, Spain.
The Science of the total environment.Sci Total Environ.2012 Dec 1;440:280-9. doi: 10.1016/j.scitotenv.2012.06.027. Epub 2012 Jul 17.
The present work reports the occurrence of pharmaceuticals and their metabolites and transformation products (TPs) in the Ebro river basin (NE Spain). Twenty-four samples of water collected along the basin were analysed using a fully automated method based on on-line turbulent chromatography-liquid
PMID 22809787

Japanese Journal

Biodegradation Characteristics of Pharmaceutical Substances by Whole Fungal Culture Trametes versicolor and its Laccase

TRAN Ngoc Han,URASE Taro,KUSAKABE Osamu
Journal of Water and Environment Technology 8(2), 125-140, 2010
… Intracellular enzymes may be involved in the degradation of ketoprofen (KEP), clofibric acid (CA), carbamazepine (CBZ), propyphenazone (PPZ), fenoprofen (FEP) and gemfibrozil (GFZ). …
NAID 130000307735

Simultaneous determination of paracetamol, caffeine and propyphenazone in ternary mixtures by micellar electrokinetic capillary chromatography

EMRE Deniz,OZALTIN Nuran
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 847(2), 126-132, 2007-03-01
NAID 10025792049

Mobility of pharmaceuticals carbamazepine, diclofenac, ibuprofen, and propyphenazone in miscible-displacement experiments

SCHEYTT T. J.
J. Contaminant Hydrology 83(1-2), 53-69, 2006
NAID 30002812593

Related Pictures

View Large Image of Propyphenazone buy Saridon (Propyphenazone + Paracetamol Bestand:Propyphenazone structure.svg View Larger Propyphénazone propyphenazone propyphenazone Adverse effects

★リンクテーブル★

リンク元	「イソプロピルアンチピリン」

「イソプロピルアンチピリン」

Propyphenazone
Systematic (IUPAC) name
	1,5-Dimethyl-2-phenyl-4-propan-2-yl-pyrazol-3-one
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Routes	Oral
Identifiers
CAS number	479-92-5
ATC code	N02BB04
PubChem	CID 3778
ChemSpider	3646
UNII	OED8FV75PY
ChEBI	CHEBI:135538
ChEMBL	CHEMBL28318
Chemical data
Formula	C14H18N2O
Mol. mass	230.306 g/mol
	SMILES O=C2\C(=C(/N(N2c1ccccc1)C)C)C(C)C;
	InChI InChI=1S/C14H18N2O/c1-10(2)13-11(3)15(4)16(14(13)17)12-8-6-5-7-9-12/h5-10H,1-4H3 ; Key:PXWLVJLKJGVOKE-UHFFFAOYSA-N ;
(what is this?) (verify);

　　[★]

英: isopropylantipyrine
ラ: isopropylantipyrinum
同: プロピフェナゾン propyphenazone、イソプロピルフェナゾン isopropylphenazone
商: SG配合、クリアミン配合、ヨシピリン
関: 非ステロイド性抗炎症薬

[1] Göres, E.; Kossowicz, J.; Schneider, H. G. (2004). [Propyphenazone. Pharmacology and use] |trans-title= requires |title= (help). Medizinische Monatsschrift für Pharmazeuten (in German) 27 (3): 72–76. PMID 15032249. edit

[2] Akyel, A.; Alsancak, Y.; Yayla, Ç. R.; Şahinarslan, A.; Özdemir, M. (2011). "Acute inferior myocardial infarction with low atrial rhythm due to propyphenazone: Kounis syndrome". International Journal of Cardiology 148 (3): 352–353. doi:10.1016/j.ijcard.2010.05.038. PMID 20541820. edit

[Rejected-3] Consolidated List of Products whose Consumption and/or Sale have been Banned, Withdrawn, Severely Restricted or not Approved by Governments, Twelfth Issue (pdf). New York: Department of Economic and Social Affairs of the United Nations Secretariat. 2005. p. 232.

[Banned-4] "Multi-Country Survey On Banned And Restricted Pharmaceuticals". Health Action International Asia Pacific. August 2008. p. 7. Missing or empty |url= (help)

[5] "Bayer’s Saridon-A Among 28 Painkillers Banned To Those Under 15 In Korea". PharmAsia News. 2009-03-12.

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propyphenazone