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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/05/26 15:54:20」(JST)

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Propyphenazone is a derivative of phenazone^[1] with similar analgesic and antipyretic effects.

Adverse effects of propyphenazone

There have been case reports describing risk of acute inferior myocardial infarction with low atrial rhythm due to propyphenazone (Kounis syndrome).^[2]^{[citation needed]}

Countries that have banned propyphenazone

Excerpt from WHO comments:

“Propyphenazone, a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, was introduced in 1951 for the treatment of rheumatic disorders. As it is structurally related to aminophenazone it has been associated with severe blood dyscrasias. However, it cannot be transformed into potentially carcinogenic nitrosamines and has therefore been widely used as a replacement drug for aminophenazone. In certain countries, products containing propyphenazone have now been restricted in their indications, whereas in others they are still available, sometimes as over-the-counter preparations.”^[3]

Sri Lanka^[4]
South Korea^[4] - as reported by PharmAsia News in 2009:

“Amid rising claims that it isn't moving fast enough to counter public concern over the safety of OTC painkillers, Korea FDA has banned Bayer Korea's painkiller Saridon-A, Samjin Pharm's Geworin and 26 other products from being prescribed or sold over the counter to those under 15 years of age.”^[5]

Malaysia^[4]
Thailand^[4]
Turkey - production and sale banned in January 1986 due to incidence of severe adverse reactions.^[3]
India- Still in use. Saridon tablets contain 150 mg/tablet.

References

^ Göres, E.; Kossowicz, J.; Schneider, H. G. (2004). "Propyphenazone. Pharmacology and use" [Propyphenazone. Pharmacology and use]. Medizinische Monatsschrift für Pharmazeuten (in German) 27 (3): 72–76. PMID 15032249.
^ Akyel, A.; Alsancak, Y.; Yayla, Ç. R.; Şahinarslan, A.; Özdemir, M. (2011). "Acute inferior myocardial infarction with low atrial rhythm due to propyphenazone: Kounis syndrome". International Journal of Cardiology 148 (3): 352–353. doi:10.1016/j.ijcard.2010.05.038. PMID 20541820.
^ ^a ^b Consolidated List of Products whose Consumption and/or Sale have been Banned, Withdrawn, Severely Restricted or not Approved by Governments, Twelfth Issue (pdf). New York: Department of Economic and Social Affairs of the United Nations Secretariat. 2005. p. 232.
^ ^a ^b ^c ^d "Multi-Country Survey On Banned And Restricted Pharmaceuticals". Health Action International Asia Pacific. August 2008. p. 7.
^ "Bayer’s Saridon-A Among 28 Painkillers Banned To Those Under 15 In Korea". PharmAsia News. 2009-03-12.

This analgesic-related article is a stub. You can help Wikipedia by expanding it.

English Journal

Determination of selected pharmaceuticals in tap water and drinking water treatment plant by high-performance liquid chromatography-triple quadrupole mass spectrometer in Beijing, China.

Cai MQ1, Wang R, Feng L, Zhang LQ.
Environmental science and pollution research international.Environ Sci Pollut Res Int.2015 Feb;22(3):1854-67. doi: 10.1007/s11356-014-3473-8. Epub 2014 Sep 9.
A simultaneous determination method of 14 multi-class pharmaceuticals using solid-phase extraction (SPE) followed by high-performance liquid chromatography-tandem mass spectrometer (HPLC-MS/MS) was established to measure the occurrence and distribution of these pharmaceuticals in tap water and a dri
PMID 25196960

Fundamental properties of a touchable high-power pulsed microplasma jet and its application as a desorption/ionization source for ambient mass spectrometry.

Iwai T1, Kakegawa K, Okumura K, Kanamori-Kataoka M, Miyahara H, Seto Y, Okino A.
Journal of mass spectrometry : JMS.J Mass Spectrom.2014 Jun;49(6):522-8. doi: 10.1002/jms.3368.
Plasma-based ambient desorption/ionization mass spectrometry (ADI-MS) has attracted considerable attention in many fields because of its capacity for direct sample analyses. In this study, a high-power pulsed microplasma jet (HPPMJ) was developed and investigated as a new plasma desorption/ionizatio
PMID 24913404

Clinical features of immediate hypersensitivity to isopropylantipyrine.

Hwang EK1, Nam YH, Jin HJ, Shin YS, Ye YM, Park HS.
Allergy, asthma & immunology research.Allergy Asthma Immunol Res.2013 Jan;5(1):55-8. doi: 10.4168/aair.2013.5.1.55. Epub 2012 Aug 29.
Hypersensitivities induced by isopropylantipyrine (IPA), a pyrazolone derivative within the wider family of non-steroidal anti-inflammatory drugs (NSAIDs), are rarely reported. We characterized the clinical features of 12 patients with IPA-induced hypersensitivity. Twelve patients with immediate hyp
PMID 23277879

Japanese Journal

症例イソプロピルアンチピリンによる蕁麻疹型薬疹の1例

山本哲久,里美佐子,大槻真弓 [他]
皮膚科の臨床 51(6), 775-778, 2009-06
NAID 40016709370

Drug-induced hepatitis with hepatic granuloma due to saridon

ABE MASANORI,KUMAGI TERU,NAKANISHI SEIJI,YAMAGAMI TAKASHI,MICHITAKA KOJIRO,ABE KAYO,OKURA IZUMI,YAMASHITA HARUHIKO,HORIIKE NORIO,ONJI MORIKAZU
Journal of gastroenterology 37(12), 1068-1072, 2002-12-01
NAID 10013893850

Related Pictures

프로필안티피린 (isopropylantipyrine 위험성분 : IPA(isopropylantipyrine 丙基安替比林|4-Isopropylantipyrine Propyphenazone / Isopropylantipyrine 479 삼진 제약 주 isopropylantipyrine Figure 2: Typical chromatogram of a Isopropylantipyrine-mixed-with-Ethenzamide

★リンクテーブル★

リンク元	「イソプロピルアンチピリン」

「イソプロピルアンチピリン」

Propyphenazone
Systematic (IUPAC) name
	1,5-Dimethyl-2-phenyl-4-propan-2-yl-pyrazol-3-one
Clinical data
AHFS/Drugs.com	International Drug Names
Administration	Oral
Identifiers
CASRN	479-92-5
ATC code	N02BB04 (WHO)
PubChem	CID 3778
ChemSpider	3646
UNII	OED8FV75PY
ChEBI	CHEBI:135538
ChEMBL	CHEMBL28318
Chemical data
Formula	C14H18N2O
Molar mass	230.306 g/mol
	SMILES O=C2\C(=C(/N(N2c1ccccc1)C)C)C(C)C ;
	InChI InChI=1S/C14H18N2O/c1-10(2)13-11(3)15(4)16(14(13)17)12-8-6-5-7-9-12/h5-10H,1-4H3 ; Key:PXWLVJLKJGVOKE-UHFFFAOYSA-N ;
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　　[★]

英: isopropylantipyrine
ラ: isopropylantipyrinum
同: プロピフェナゾン propyphenazone、イソプロピルフェナゾン isopropylphenazone
商: SG配合、クリアミン配合、ヨシピリン
関: 非ステロイド性抗炎症薬

[1] Göres, E.; Kossowicz, J.; Schneider, H. G. (2004). "Propyphenazone. Pharmacology and use" [Propyphenazone. Pharmacology and use]. Medizinische Monatsschrift für Pharmazeuten (in German) 27 (3): 72–76. PMID 15032249.

[2] Akyel, A.; Alsancak, Y.; Yayla, Ç. R.; Şahinarslan, A.; Özdemir, M. (2011). "Acute inferior myocardial infarction with low atrial rhythm due to propyphenazone: Kounis syndrome". International Journal of Cardiology 148 (3): 352–353. doi:10.1016/j.ijcard.2010.05.038. PMID 20541820.

[Rejected-3] Consolidated List of Products whose Consumption and/or Sale have been Banned, Withdrawn, Severely Restricted or not Approved by Governments, Twelfth Issue (pdf). New York: Department of Economic and Social Affairs of the United Nations Secretariat. 2005. p. 232.

[Banned-4] "Multi-Country Survey On Banned And Restricted Pharmaceuticals". Health Action International Asia Pacific. August 2008. p. 7.

[5] "Bayer’s Saridon-A Among 28 Painkillers Banned To Those Under 15 In Korea". PharmAsia News. 2009-03-12.

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isopropylantipyrine