進行性非流暢性失語
- 関
- primary progressive aphasia
WordNet
- gradually advancing in extent
- a tense of verbs used in describing action that is on-going (同)progressive tense, imperfect, imperfect tense, continuous tense
- favoring or promoting reform (often by government action) (同)reformist, reform-minded
- (of a card game or a dance) involving a series of sections for which the participants successively change place or relative position; "progressive euchre"; "progressive tournaments"
- (of taxes) adjusted so that the rate increases as the amount of income increases
- advancing in severity; "progressive paralysis"
- favoring or promoting progress; "progressive schools"
- inability to use or understand language (spoken or written) because of a brain lesion
PrepTutorEJDIC
- (行列などが)『前進する』,進んで行く / (事態が)進展する,進行する / 『進歩的な』,革新的な / (病気・暴力などが)次第に悪くなる(広がる) / (課税が)累進的な / (文法で)進行[形]の / 進歩的な人,革新主義者
- 失語症
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/05/10 15:53:12」(JST)
[Wiki en表示]
Main articles: Aphasia and Primary progressive aphasia
Progressive nonfluent aphasia is one of three clinical syndromes associated with frontotemporal lobar degeneration. The major symptom is progressive difficulties with the production of speech.
Contents
- 1 Clinical features
- 2 Classification
- 3 Imaging
- 4 Management
- 5 See also
- 6 References
- 7 Further reading
- 8 External links
Clinical features
The main clinical features are progressive difficulties with speech production. There can be problems in different parts of the speech production system, hence patients can present with articulatory breakdown, phonemic breakdown (difficulties with sounds) and other problems. However, it is rare for patients to have just one of these problems and most people will present with more than one problem. Features include:
- Hesitant, effortful speech
- Speech 'apraxia'
- Stutter (including return of a childhood stutter)
- Anomia
- Phonemic paraphasia (sound errors in speech e.g. 'gat' for 'cat')
- Agrammatism (using the wrong tense or word order)
As the disease develops, speech quantity decreases and many patients will become mute.
Cognitive domains other than language are rarely affected early on. However, as the disease progresses other domains can be affected. Problems with writing, reading and speech comprehension can occur as can behavioural features similar to frontotemporal dementia.
Classification
There is some confusion in the terminology used by different neurologists. Mesulam's original description in 1982 of progressive language problems caused by neurodegenerative disease (which he called Primary Progressive Aphasia (PPA) [1][2] included patients with progressive non-fluent (PNFA), Semantic Dementia(SD), and Logopenic progressive aphasia (LPA).[3][4][5]
Imaging
Imaging studies have shown differing results which probably represents the heterogeneity of language problems than can occur in PNFA. However, classically atrophy of left perisylvian areas is seen. Comprehensive meta-analyses on MRI and FDG-PET studies identified alterations in the whole left frontotemporal network for phonological and syntactical processing as the most consistent finding.[6] Based on these imaging methods, progressive nonfluent aphasia can be regionally dissociated from the other subtypes of frontotemporal lobar degeneration, frontotemporal dementia and semantic dementia.
Management
There is no curative treatment for this condition. Supportive management is helpful.
See also
- Alzheimer's disease
- Corticobasal degeneration
- Frontotemporal dementia
- Frontotemporal lobar degeneration
- Logopenic progressive aphasia
- Pick's disease
- Semantic dementia
References
- ^ Mesulam M (1982). "Slowly progressive aphasia without generalized dementia". Ann Neurol. 11 (6): 592–8. doi:10.1002/ana.410110607. PMID 7114808.
- ^ Mesulam MM (April 2001). "Primary progressive aphasia". Ann. Neurol. 49 (4): 425–32. doi:10.1002/ana.91. PMID 11310619.
- ^ Gorno-Tempini ML, Hillis AE, Weintraub S, et al. (March 2011). "Classification of primary progressive aphasia and its variants". Neurology 76 (11): 1006–14. doi:10.1212/WNL.0b013e31821103e6. PMC 3059138. PMID 21325651.
- ^ Bonner MF, Ash S, Grossman M (November 2010). "The new classification of primary progressive aphasia into semantic, logopenic, or nonfluent/agrammatic variants". Curr Neurol Neurosci Rep 10 (6): 484–90. doi:10.1007/s11910-010-0140-4. PMC 2963791. PMID 20809401.
- ^ Harciarek M, Kertesz A (September 2011). "Primary progressive aphasias and their contribution to the contemporary knowledge about the brain-language relationship". Neuropsychol Rev 21 (3): 271–87. doi:10.1007/s11065-011-9175-9. PMC 3158975. PMID 21809067.
- ^ Schroeter ML, Raczka KK, Neumann J, von Cramon DY (2007). "Towards a nosology for frontotemporal lobar degenerations – A meta-analysis involving 267 subjects.". NeuroImage 36 (3): 497–510. doi:10.1016/j.neuroimage.2007.03.024. PMID 17478101.
Further reading
- Gliebus G (March 2010). "Primary progressive aphasia: clinical, imaging, and neuropathological findings". Am J Alzheimers Dis Other Demen 25 (2): 125–7. doi:10.1177/1533317509356691. PMID 20124255.
- Gorno-Tempini ML, Dronkers NF, Rankin KP, et al. (March 2004). "Cognition and anatomy in three variants of primary progressive aphasia". Ann. Neurol. 55 (3): 335–46. doi:10.1002/ana.10825. PMC 2362399. PMID 14991811.
- Henry ML, Gorno-Tempini ML (December 2010). "The logopenic variant of primary progressive aphasia". Curr. Opin. Neurol. 23 (6): 633–7. doi:10.1097/WCO.0b013e32833fb93e. PMC 3201824. PMID 20852419.
- Mesulam MM (October 2003). "Primary progressive aphasia—a language-based dementia". N. Engl. J. Med. 349 (16): 1535–42. doi:10.1056/NEJMra022435. PMID 14561797.
- Reilly J, Rodriguez AD, Lamy M, Neils-Strunjas J (2010). "Cognition, language, and clinical pathological features of non-Alzheimer's dementias: an overview". J Commun Disord 43 (5): 438–52. doi:10.1016/j.jcomdis.2010.04.011. PMC 2922444. PMID 20493496.
- Rohrer JD, Knight WD, Warren JE, Fox NC, Rossor MN, Warren JD (January 2008). "Word-finding difficulty: a clinical analysis of the progressive aphasias". Brain 131 (Pt 1): 8–38. doi:10.1093/brain/awm251. PMC 2373641. PMID 17947337.
External links
- FTD information and videos from the UCSF Memory and Aging Center
- FTD Info from the Mayo Clinic
- The Association for Frontotemporal Dementias
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Symptoms and signs: Speech and voice / Symptoms involving head and neck (R47–R49, 784)
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| Acute Aphasias |
- Expressive aphasia
- Receptive aphasia
- Conduction aphasia
- Anomic aphasia
- Global aphasia
- Transcortical sensory aphasia
- Transcortical motor aphasia
- Mixed transcortical aphasia
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| Progressive Aphasias |
- Progressive nonfluent aphasia
- Semantic dementia
- Logopenic progressive aphasia
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| Other speech disturbances |
- Speech disorder
- Developmental verbal dyspraxia/Apraxia of speech
- Auditory verbal agnosia
- Dysarthria
- Schizophasia
- Aprosodia/Dysprosody
- Specific language impairment
- Thought disorder
- Pressure of speech
- Derailment
- Clanging
- Circumstantiality
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| Communication disorders |
- Developmental dyslexia/Alexia
- Agnosia
- Astereognosis
- Prosopagnosia
- Visual agnosia
- Gerstmann syndrome
- Developmental coordination disorder/Apraxia
- Dyscalculia/Acalculia
- Agraphia
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| Voice disturbances |
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| Other |
- Auditory processing disorder
- Epistaxis
- Headache
- Post-nasal drip
- Neck mass
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dsrd (o, p, m, p, a, d, s), sysi/epon, spvo
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proc (eval/thrp), drug (N5A/5B/5C/6A/6B/6D)
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noco/cofa (c)/cogi/tumr, sysi
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UpToDate Contents
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English Journal
- Social cognition, executive functioning, and neuroimaging correlates of empathic deficits in frontotemporal dementia.
- Eslinger PJ, Moore P, Anderson C, Grossman M.SourceDepartment of Neurology, EC037, PA State Hershey Medical Center, P.O. Box 850, Hershey, PA 17033-0850, USA. peslinger@psu.edu
- The Journal of neuropsychiatry and clinical neurosciences.J Neuropsychiatry Clin Neurosci.2011 Fall;23(1):74-82.
- The authors investigated aspects of interpersonal sensitivity and perspective-taking in relation to empathy, social cognitions, and executive functioning in 26 frontotemporal dementia (FTD) patients. Behavioral-variant FTD (bvFTD) patients were significantly impaired on caregiver assessments of empa
- PMID 21304142
- Auditory object cognition in dementia.
- Goll JC, Kim LG, Hailstone JC, Lehmann M, Buckley A, Crutch SJ, Warren JD.SourceDementia Research Centre, Institute of Neurology, University College London, 8-11 Queen Square, London WC1N 3BG, United Kingdom.
- Neuropsychologia.Neuropsychologia.2011 Jun 13. [Epub ahead of print]
- The cognition of nonverbal sounds in dementia has been relatively little explored. Here we undertook a systematic study of nonverbal sound processing in patient groups with canonical dementia syndromes comprising clinically diagnosed typical amnestic Alzheimer's disease (AD; n=21), progressive nonfl
- PMID 21689671
Japanese Journal
- 症例報告 開眼失行を呈した筋萎縮性側索硬化症/前頭側頭葉変性症の1例
Related Links
- Progressive nonfluent aphasia is one of three clinical syndromes associated with frontotemporal lobar degeneration. The major symptom is progressive difficulties with the production of speech. ...
Related Pictures
★リンクテーブル★
[★]
- 英
- frontotemporal lobar degeneration
- 同
- 前頭側頭型認知症？
- 関
- 痴呆、家族性痴呆症、意味性痴呆
HBN.930
- 広義のピック病
- 前頭葉・側頭葉が神経細胞脱落によって萎縮する疾患群。Pick小体の有無を問わない。
臨床型
[★]
原発性進行性失語
- 関
- PPA、progressive nonfluent aphasia
[★]
- 英
- progressive nonfluent aphasia
- 関
- 原発性進行性失語
[★]
非流暢性失語
- 関
- agrammatism、Broca aphasia、expressive aphasia、motor aphasia
[★]
- 関
- progressively