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1. 血栓溶解異常による血栓性および出血性疾患 thrombotic and hemorrhagic disorders due to abnormal fibrinolysis
2. 急性膵炎の重症度予測 predicting the severity of acute pancreatitis

Szabó A1, Pilsak C2, Bence M1, Witt H3, Sahin-Tóth M4.
The Journal of biological chemistry.J Biol Chem.2016 Aug 19;291(34):17706-16. doi: 10.1074/jbc.M116.743237. Epub 2016 Jun 29.
The pancreas secretes digestive proenzymes typically in their monomeric form. A notable exception is the ternary complex formed by proproteinase E, chymotrypsinogen C, and procarboxypeptidase A (proCPA) in cattle and other ruminants. In the human and pig pancreas binary complexes of proCPA with proe
PMID 27358403

Digestive enzymatic patterns as possible biomarkers of endocrine disruption in the red mullet (Mullus barbatus): A preliminary investigation.

Caruso G1, De Pasquale F2, Mita DG3, Micale V4.
Marine pollution bulletin.Mar Pollut Bull.2016 Apr 15;105(1):37-42. doi: 10.1016/j.marpolbul.2016.03.005. Epub 2016 Mar 9.
During two seasonal trawl surveys (April and October, 2012), red mullet specimens were caught from two sites of the northern Sicilian coast (Western Mediterranean), characterized by different degrees of pollution, to assess whether their digestive enzymes could be cost-effective diagnostic tools for
PMID 26971230

Knockdown of Carboxypeptidase A6 in Zebrafish Larvae Reduces Response to Seizure-Inducing Drugs and Causes Changes in the Level of mRNAs Encoding Signaling Molecules.

Lopes MW1, Sapio MR2, Leal RB1, Fricker LD2,3.
PloS one.PLoS One.2016 Apr 6;11(4):e0152905. doi: 10.1371/journal.pone.0152905. eCollection 2016.
Carboxypeptidase A6 (CPA6) is an extracellular matrix metallocarboxypeptidase that modulates peptide and protein function by removal of hydrophobic C-terminal amino acids. Mutations in the human CPA6 gene that reduce enzymatic activity in the extracellular matrix are associated with febrile seizures
PMID 27050163

Procarboxypeptidase R Deficiency Causes Increased Lethality in Concanavalin A-Induced Hepatitis in Female Mice

Asai Suzuka,Kimbara Noriaki,Tada Toyohiro [他],Imai Masaki,Campbell William,Okada Hidechika,Okada Noriko
Biological and Pharmaceutical Bulletin 33(7), 1256-1259, 2010
Carboxypeptidase R (CPR), also known as thrombin-activatable fibrinolysis inhibitor (TAFI), is an enzyme generated by proteolytic cleavage of its zymogen (proCPR). CPR removes the C-terminal arginine …
NAID 130000300299

Purification of Inactive Precursor of Carboxypeptidase Y Using Selective Cleavage Method Coupled with Molecular Display

Maeda Haruko,Nagayama Mitsuru,Kuroda Kouichi [他],UEDA Mitsuyoshi
Bioscience, biotechnology, and biochemistry 73(3), 753-755, 2009-03-23
… We purified an inactive precursor protein, procarboxypeptidase Y (proCPY), which was displayed on the cell surface of yeast, due to difficulty of purifying it by a system in which it is produced in cells. …
NAID 10027539221

He Lianying,Asai Suzuka,Kawamura Takeshi [他],KIMBARA Noriaki,TADA Toyohiro,OKADA Hidechika,OKADA Noriko
Microbiology and immunology 49(4), 373-380, 2005-04-20
NAID 10015527968