WordNet

complicated in structure; consisting of interconnected parts; "a complex set of variations based on a simple folk melody"; "a complex mass of diverse laws and customs"
a compound described in terms of the central atom to which other atoms are bound or coordinated (同)coordination_compound
a conceptual whole made up of complicated and related parts; "the complex of shopping malls, houses, and roads created a new town" (同)composite
(psychoanalysis) a combination of emotions and impulses that have been rejected from awareness but still influence a persons behavior

PrepTutorEJDIC

『いくつかの部分から成る』,複合の,合成の / 『複雑な』,入りくんだ,こみいった(complicated) / 複合体,合成物 / コンプレックス,複合(抑圧されて心に残った複雑なしこり)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/04/27 14:57:19」(JST)

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The pre-integration complex (PIC) is a nucleoprotein complex of viral genetic material and associated viral and host proteins. The PIC forms after uncoating of a viral particle after entry into the host cell. In the case of the human immunodeficiency virus (HIV), the PIC consists of viral proteins (including Vpr, matrix and integrase), host proteins (including Barrier to autointegration factor 1) and two strands of the ribonucleic acid (RNA) genome. Within the HIV PIC, the process of reverse transcription converts the viral RNA genome into double-stranded DNA (dsDNA). The PIC enters the cellular nucleus through the nuclear pore complex without disrupting the nuclear envelope, thus allowing HIV and related retroviruses to replicate in non-dividing cells.^[1]^[2] Following nuclear entry, the PIC's DNA payload may be integrated into the host DNA as a "provirus".^[3]

External links

http://www.mcld.co.uk/hiv/?q=preintegration%20complex

http://search.proquest.com/docview/224644188/fulltextPDF?accountid=14214#

References

^ Piller, S. C.; Caly, L.; Jans, D. A. (2003). "Nuclear import of the pre-integration complex (PIC): the Achilles heel of HIV?". Current drug targets 4 (5): 409–429. doi:10.2174/1389450033490984. PMID 12816349. edit
^ De Rijck, J.; Vandekerckhove, L.; Christ, F.; Debyser, Z. (2007). "Lentiviral nuclear import: a complex interplay between virus and host". BioEssays : news and reviews in molecular, cellular and developmental biology 29 (5): 441–451. doi:10.1002/bies.20561. PMID 17450594. edit
^ Smith, Johanna A.; Nunnari, Giuseppe; Preuss, Mirjam ; Pomerantz, Roger J.; Daniel, René (Division of Infectious Diseases, Center for Human Virology, Thomas Jefferson University, Philadelphia) (2007). "Pentoxifylline Suppresses Transduction by HIV-1-Based Vectors". Intervirology 50 (5): 377–386. doi:10.1159/000109752. PMID 17938572.

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1. QRS幅の狭い頻脈の臨床症状、診断、および評価 clinical manifestations diagnosis and evaluation of narrow qrs complex tachycardias
2. 血漿分画製剤および組換えDNA産生凝固因子 plasma derivatives and recombinant dna produced coagulation factors
3. 複合形質の遺伝の原則 principles of complex trait genetics
4. QRS幅の広い頻脈のマネージメントおよび評価 management and evaluation of wide qrs complex tachycardia in children
5. QRS幅の広い頻脈の診断および治療のアプローチ approach to the diagnosis and treatment of wide qrs complex tachycardias

English Journal

Cocaine modulates HIV-1 integration in primary CD4+ T cells: implications in HIV-1 pathogenesis in drug-abusing patients.

Addai AB1, Pandhare J1, Paromov V1, Mantri CK1, Pratap S1, Dash C2.
Journal of leukocyte biology.J Leukoc Biol.2015 Apr;97(4):779-90. doi: 10.1189/jlb.4A0714-356R. Epub 2015 Feb 17.
Epidemiologic studies suggest that cocaine abuse worsens HIV-1 disease progression. Increased viral load has been suggested to play a key role for the accelerated HIV disease among cocaine-abusing patients. The goal of this study was to investigate whether cocaine enhances proviral DNA integration a
PMID 25691383

HIV-1 IN/Pol recruits LEDGF/p75 into viral particles.

Desimmie BA, Weydert C, Schrijvers R, Vets S, Demeulemeester J, Proost P, Paron I, De Rijck J, Mast J, Bannert N, Gijsbers R, Christ F, Debyser Z.
Retrovirology.Retrovirology.2015 Feb 12;12:16. doi: 10.1186/s12977-014-0134-4.
BACKGROUND: The dynamic interaction between HIV and its host governs the replication of the virus and the study of the virus-host interplay is key to understand the viral lifecycle. The host factor lens epithelium-derived growth factor (LEDGF/p75) tethers the HIV preintegration complex to the chroma
PMID 25809198

Structural basis of HIV-1 capsid recognition by PF74 and CPSF6.

Bhattacharya A1, Alam SL2, Fricke T3, Zadrozny K4, Sedzicki J4, Taylor AB1, Demeler B1, Pornillos O5, Ganser-Pornillos BK4, Diaz-Griffero F3, Ivanov DN6, Yeager M7.
Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2014 Dec 30;111(52):18625-30. doi: 10.1073/pnas.1419945112. Epub 2014 Dec 17.
Upon infection of susceptible cells by HIV-1, the conical capsid formed by ∼250 hexamers and 12 pentamers of the CA protein is delivered to the cytoplasm. The capsid shields the RNA genome and proteins required for reverse transcription. In addition, the surface of the capsid mediates numerous hos
PMID 25518861

Japanese Journal

The integrase interactor 1 (INI1) proteins facilitate Tat-mediated human immunodeficiency virus type 1 transcription

Retrovirology 3, 2006-08-05
NAID 120002306937

HIV-1ゲノム動態に関与する宿主因子群とその制御

ウイルス 56(1), 41-50, 2006-06-26
NAID 10017992195

Biochemical and genetic analyses of integrase-interacting proteins lens epithelium-derived growth factor (LEDGF)/p75 and hepatoma-derived growth factor related protein 2 (HRP2) in preintegration complex function and HIV-1 replication