WordNet

any compound that contains water of crystallization
become hydrated and combine with water
cause to be hydrated; add water or moisture to; "hydrate your skin"
supply water or liquid to in order to maintain a healthy balance; "the bicyclists must be hydrated frequently"
small tubular solitary freshwater hydrozoan polyp
trouble that cannot be overcome by a single effort because of its many aspects or its persistent and pervasive quality; "we may be facing a hydra that defies any easy solution"

PrepTutorEJDIC

含水化合物,水化物 / 〈化合物〉‘を'水和させて水化物を作る

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/05/10 17:14:56」(JST)

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[Wiki en表示]

Pranlukast (brand name Onon, オノン) is a cysteinyl leukotriene receptor-1 antagonist. This drug works similarly to Merck & Co.'s montelukast (Singulair). It is widely used in Japan.

Medications of this class, which go under a variety of names according to whether one looks at the American, British or European system of nomenclature, have as their primary function the antagonism of bronchospasm caused, principally in asthmatics, by an allergic reaction to accidentally or inadvertently encountered allergens.

Medications of this group are normally used as an adjunct to the standard therapy of inhaled steroids with inhaled long- and/or short-acting beta-agonists. There are several similar medications in the group; all appear to be equally effective.

References

^ ^a ^b Nakade S, Ueda S, Ohno T, Nakayama K, Miyata Y, Yukawa E, Higuchi S (2006). "Population pharmacokinetics of pranlukast hydrate dry syrup in children with allergic rhinitis and bronchial asthma.". Drug Metab Pharmacokinet 21 (2): 133–9. doi:10.2133/dmpk.21.133. PMID 16702733.

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English Journal

Effects of pranlukast hydrate on airway hyperresponsiveness in non-asthmatic patients with Japanese cedar pollinosis.

Sagara H, Yukawa T, Kashima R, Okada T, Fukuda T.SourceDepartment of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine, Tochigi, Japan. h-sagara@dokkyomed.ac.jp
Allergology international : official journal of the Japanese Society of Allergology.Allergol Int.2009 Jun;58(2):277-87. Epub 2009 Apr 25.
BACKGROUND: Recent studies have suggested that allergic rhinitis is closely related to bronchial asthma, reflecting the "one airway-one disease" hypothesis. It is unclear if the effects of pranlukast, a leukotriene-receptor antagonist, are consistent with this hypothesis.OBJECTIVE: The goal of the s
PMID 19390239

The inhibitory effect of the leukotriene receptor antagonist on leukotriene D4-induced MUC2/5AC gene expression and mucin secretion in human airway epithelial cells.

Bai CH, Song SY, Kim YD.SourceDepartment of Otorhinolaryngology, College of Medicine, Yeungnam University, South Korea.
Auris, nasus, larynx.Auris Nasus Larynx.2007 Jun;34(2):203-6. Epub 2007 Jan 12.
OBJECTIVES: Mucin gene expression and mucin production are markedly increased in inflammatory airway disorders such as asthma, chronic bronchitis and rhinosinusitis. Cytokines, lipopolysaccharides and other inflammatory mediators such as prostaglandin and leukotriene are related to the secretion and
PMID 17223000

Japanese Journal

スギ花粉症合併喘息におけるスギ花粉飛散時期の鼻炎および喘息症状増悪に対するプランルカストとフェキソフェナシンの効果の比較検討

渡邉直人,星野誠,中川武正 [他]
日本職業・環境アレルギー学会雑誌 17(2), 25-32, 2010-05
NAID 40017262987

1歳未満の気管支喘息に対するオノンドライシロップ10% (プランルカスト水和物) 製造販売後調査結果 : プロスペクティヴ調査

岩田力,栗原和幸,小田島安平,宇理須厚雄,井上壽茂,河野陽一,森川昭廣
日本小児アレルギー学会誌 = The Japanese journal of pediatric allergy and clinical immunology 23(5), 629-642, 2009-12-25
NAID 10026284904

Effects of Pranlukast Hydrate on Airway Hyperresponsiveness in Non-Asthmatic Patients with Japanese Cedar Pollinosis

SAGARA Hironori,YUKAWA Tatsuo,KASHIMA Ryuichi,OKADA Takenori,FUKUDA Takeshi
Allergology international : official journal of the Japanese Society of Allergology 58(2), 277-287, 2009-06-01
NAID 10025109874

「プランルカスト」

Pranlukast
Systematic (IUPAC) name
	N-[4-oxo-2-(1H-tetrazol-5-yl)-4H-chromen-8-yl]-4-(4-phenylbutoxy)benzamide
Clinical data
Trade names	Onon (オノン)
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral
Pharmacokinetic data
Metabolism	Hepatic (mainly CYP3A4)
Biological half-life	1.5 hours
Identifiers
CAS Number	103177-37-3
ATC code	R03DC02 (WHO)
PubChem	CID 4887
IUPHAR/BPS	3634
DrugBank	DB01411
ChemSpider	4718
UNII	TB8Z891092
ChEMBL	CHEMBL21333
Chemical data
Formula	C27H23N5O4
Molar mass	481.503 g/mol
	SMILES O=C(c2ccc(OCCCCc1ccccc1)cc2)Nc5cccc3c5O/C(=C\C3=O)c4nnnn4 ;
	InChI InChI=1S/C27H23N5O4/c33-23-17-24(26-29-31-32-30-26)36-25-21(23)10-6-11-22(25)28-27(34)19-12-14-20(15-13-19)35-16-5-4-9-18-7-2-1-3-8-18/h1-3,6-8,10-15,17H,4-5,9,16H2,(H,28,34)(H,29,30,31,32) ; Key:NBQKINXMPLXUET-UHFFFAOYSA-N ;
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