WordNet

an impairment of health or a condition of abnormal functioning
of or relating to an inheritable character that is controlled by several genes at once; of or related to or determined by polygenes

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1. 遺伝性疾患の基本原則 basic principles of genetic disease
2. 小児における脂質異常症の定義およびスクリーニング definition and screening for dyslipidemia in children
3. 心房細動の疫学および危険因子 epidemiology of and risk factors for atrial fibrillation
4. 男性における男性型脱毛症：病因、臨床的特徴、および診断 androgenetic alopecia in men pathogenesis clinical features and diagnosis
5. 特発性脳動脈および頚動脈の解離：臨床的特徴および診断 spontaneous cerebral and cervical artery dissection clinical features and diagnosis

Persico AM, Napolioni V.SourceChild and Adolescent Neuropsychiatry Unit, University "Campus Bio-Medico", Rome, Italy; Department of Experimental Neurosciences, IRCCS "Fondazione Santa Lucia", Rome, Italy; Mafalda Luce Center for Pervasive Developmental Disorders, Milan, Italy. Electronic address: a.persico@unicampus.it.
Behavioural brain research.Behav Brain Res.2013 Aug 15;251:95-112. doi: 10.1016/j.bbr.2013.06.012. Epub 2013 Jun 13.
Autism spectrum disorder (ASD) is a severe neuropsychiatric disease with strong genetic underpinnings. However, genetic contributions to autism are extremely heterogeneous, with many different loci underlying the disease to a different extent in different individuals. Moreover, the phenotypic expres
PMID 23769996

Deng H, Xiu X, Song Z.SourceCenter for Experimental Medicine, the Third Xiangya Hospital, Central South University, Tongzipo Road 138, Changsha, Hunan, 410013, People's Republic of China, hdeng008@yahoo.com.
Molecular neurobiology.Mol Neurobiol.2013 Aug 10. [Epub ahead of print]
Epilepsy is one of the most common neurological disorders characterized by abnormal electrical activity in the central nervous system. The clinical features of this disorder are recurrent seizures, difference in age onset, type, and frequency, leading to motor, sensory, cognitive, psychic, or autono
PMID 23934645

Sanders AR, Göring HH, Duan J, Drigalenko EI, Moy W, Freda J, He D, Shi J; MGS, Gejman PV.SourceDepartment of Psychiatry and Behavioral Sciences, NorthShore University HealthSystem, Evanston, IL 60201, USA.
Human molecular genetics.Hum Mol Genet.2013 Aug 7. [Epub ahead of print]
Schizophrenia genome-wide association studies (GWAS) have identified common SNPs, rare copy number variants (CNVs) and a large polygenic contribution to illness risk, but biological mechanisms remain unclear. Bioinformatic analyses of significantly associated genetic variants point to a large role f
PMID 23904455

Genomic study of ossification of the posterior longitudinal ligament of the spine

Proceedings of the Japan Academy, Series B 90(10), 405-412, 2014
… OPLL occurs in patients with monogenic metabolic diseases including rickets/osteomalacia and hypoparathyroidism; … however most of OPLL is idiopathic and is considered as a multi-factorial (polygenic) disease influenced by genetic and environmental factors. …
NAID 130004704859

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Annals of Vascular Diseases
… In the study of susceptibility loci to vasculitis in MRL mouse models, we found that systemic vasculitis developed through the cumulative effect of multiple gene loci, each of which by itself did not have a significant effect in inducing the related phenotype, thus indicating a polygenic system.The mice developed vasculitis in an additive manner with a hierarchical effect. … Some of the susceptibility loci seemed to be common to those in other collagen diseases. …
NAID 130004487995

Genes and molecules related to obesity and lifestyle-related disease and exercise

The Journal of Physical Fitness and Sports Medicine 2(1), 111-115, 2013
… Many candidate genes related to polygenic obesity were reported in genome-wide association studies (GWAS) that compared the frequency of single-nucleotide polymorphisms (SNPs) between normal and obese individuals. … Recently, it was reported that obesity and lifestyle-related diseases may be induced epigenetically. … Understanding obesity and lifestyle-related diseases at the molecular level will undoubtedly be helpful. …
NAID 130003379933