of or relating to an inheritable character that is controlled by several genes at once; of or related to or determined by polygenes
involving or depending on several factors or causes (especially pertaining to a condition or disease resulting from the interaction of many genes)
English Journal
Association of functional genetic variants of transcription factor Forkhead Box P3 and Nuclear Factor-κB with end-stage renal disease and renal allograft outcome.
Gene.Gene.2016 Apr 25;581(1):57-65. doi: 10.1016/j.gene.2016.01.028. Epub 2016 Jan 19.
BACKGROUND: The transcription factor FOXP3 and NF-κB regulates the expression of various genes that play an important role in the regulation of renal inflammation. We investigated the association of FOXP3 (rs2232365, rs3761548, rs5902434 and rs2294021) and NF-κB1 (rs28362491 and rs696) gene varian
Artificial neural network-based exploration of gene-nutrient interactions in folate and xenobiotic metabolic pathways that modulate susceptibility to breast cancer.
Gene.Gene.2016 Apr 15;580(2):159-68. doi: 10.1016/j.gene.2016.01.023. Epub 2016 Jan 16.
In the current study, an artificial neural network (ANN)-based breast cancer prediction model was developed from the data of folate and xenobiotic pathway genetic polymorphisms along with the nutritional and demographic variables to investigate how micronutrients modulate susceptibility to breast ca
The interaction of combined effects of the BDNF and PRKCG genes and negative life events in major depressive disorder.
Yang C1, Sun N1, Liu Z1, Li X1, Xu Y1, Zhang K2.
Psychiatry research.Psychiatry Res.2016 Mar 30;237:72-7. doi: 10.1016/j.psychres.2016.01.076. Epub 2016 Feb 3.
Major depressive disorder (MDD) is a mental disorder that results from complex interplay between multiple and partially overlapping sets of susceptibility genes and environmental factors. The brain derived neurotrophic factor (BDNF) and Protein kinase C gamma type (PRKCG) are logical candidate genes
Interaction among CYP2C8, EPHX2, and CYP4A11 Gene Variants Significantly Increases the Risk for Ischemic Stroke in Chinese Populations
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Journal of Atherosclerosis and Thrombosis advpub(0), 2015
… Gene–gene interactions were analyzed using generalized multifactor dimensionality reduction (GMDR) methods.Results: Apart fro m variant rs9333025, there were no significant differences in the genotype distributions of the other nine variants between the two groups using the single–locus analytical approach. …
Multifactor leadership styles and new exposure to workplace bullying: a six-month prospective study
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Industrial Health 53(2), 139-151, 2015
… The leadership variables and exposure to bullying were measured by Multifactor Leadership Questionnaire and Negative Acts Questionnaire-Revised, respectively. …
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