WordNet

small room in which a monk or nun lives (同)cubicle
a device that delivers an electric current as the result of a chemical reaction (同)electric cell
a room where a prisoner is kept (同)jail cell, prison cell
(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
any small compartment; "the cells of a honeycomb"
a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
(physical chemistry) a fourth state of matter distinct from solid or liquid or gas and present in stars and fusion reactors; a gas becomes a plasma when it is heated until the atoms lose all their electrons, leaving a highly electrified collection of nuclei and free electrons; "particles in space exist in the form of a plasma"
a green slightly translucent variety of chalcedony used as a gemstone
the colorless watery fluid of the blood and lymph that contains no cells, but in which the blood cells (erythrocytes, leukocytes, and thrombocytes) are suspended (同)plasm, blood_plasma
an abnormal or physiologically unbalanced state of the body

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(刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
(また『blood plasma』)血漿,リンパ漿 / 原形質

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/02/27 13:36:12」(JST)

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Plasma cell dyscrasias are cancers of the plasma cells. Plasma cell dyscrasias are produced as a result of malignant proliferation of a monoclonal population of plasma cells that may or may not secrete detectable levels of a monoclonal immunoglobulin or paraprotein commonly referred to as M protein. Although the most common plasma cell dyscrasia is monoclonal gammopathy of undetermined significance (MGUS); closely related disorders include multiple myeloma, solitary plasmacytoma of bone, extramedullary plasmacytoma, Waldenström's macroglobulinemia (WM), primary amyloidosis, light chain deposition disease and heavy-chain disease. The spectrum of MGUS, solitary plasmacytoma of bone, and asymptomatic and symptomatic multiple myeloma may actually represent a natural progression of the same disease.^[1]

See paraproteinemia

Classification[edit]

Cryoglobulinemia
Heavy chain disease
Monoclonal gammopathy of undetermined significance
Multiple myeloma
Plasmacytoma
Plasma cell leukemia
POEMS syndrome
Primary amyloidosis (Immunoglobulin light chain amyloidosis)
Waldenström's macroglobulinemia

References[edit]

^ http://www.accessmedicine.com/content.aspx?aid=2794254 DEAD URL DEC 2012

External links[edit]

Multiple Myeloma and Other Plasma Cell Dyscrasias. 2011

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UpToDate Contents

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1. 多発性骨髄腫の臨床的特徴、検査所見、および診断 clinical features laboratory manifestations and diagnosis of multiple myeloma
2. POEMS症候群 poems syndrome
3. 形質細胞白血病 plasma cell leukemia
4. 造血腫瘍の分類 classification of the hematopoietic neoplasms
5. 末梢神経と筋肉に影響を与える腫瘍随伴性症候群 paraneoplastic syndromes affecting peripheral nerve and muscle

English Journal

Transcriptional dysregulation of the deleted in colorectal carcinoma gene in multiple myeloma and monoclonal gammopathy of undetermined significance.

Nagoshi H1, Taki T2, Chinen Y1, Tatekawa S1, Tsukamoto T1, Maegawa S1, Yamamoto-Sugitani M1, Tsutsumi Y1,3, Kobayashi T1, Matsumoto Y1, Horiike S1, Okuno Y4, Fujiwara S4, Hata H5, Kuroda J1, Taniwaki M1,2.
Genes, chromosomes & cancer.Genes Chromosomes Cancer.2015 Sep 22. doi: 10.1002/gcc.22290. [Epub ahead of print]
The deleted in colorectal carcinoma (DCC) gene at 18q21 encodes a netrin-1 receptor, a tumor suppressor that prevents cell growth. While allele loss or decreased expression of DCC has been associated with the progression of solid tumors and hematologic malignancies, including leukemias and malignant
PMID 26390996

Prognostic value of serum heavy/light chain ratios in patients with POEMS syndrome.

Wang C1, Su W2, Cai QQ1, Cai H1, Ji W2, Di Q2, Duan MH1, Cao XX1, Zhou DB1, Li J1.
European journal of haematology.Eur J Haematol.2015 Sep 18. doi: 10.1111/ejh.12682. [Epub ahead of print]
POEMS syndrome is a rare plasma cell dyscrasia. Serum concentrations of the monoclonal protein in this disorder is typically low, and inapplicable to monitor disease activity in most cases, resulting in limited practical and prognostic values. Novel immunoassays measuring isotype-specific heavy/ligh
PMID 26383741

Strengths and weaknesses of methods for identifying monoclonal free light chains of Ig: examples from two cases with renal disease.

Levinson SS.
Clinical chemistry and laboratory medicine : CCLM / FESCC.Clin Chem Lab Med.2015 Sep 12. pii: /j/cclm.ahead-of-print/cclm-2015-0482/cclm-2015-0482.xml. doi: 10.1515/cclm-2015-0482. [Epub ahead of print]
BACKGROUND: Serum free light chain (FLC) analysis with ratio and urine immunofixation electrophoresis (IFE) are both available for routine use in helping to detect plasma cell dyscrasia and related diseases.CASES: Case reports showing one serum positive for serum FLC but that showed a hook effect an
PMID 26368046