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1. 過敏性腸症候群に対するアロセトロン塩酸塩（Lotronex） alosetron hydrochloride lotronex for irritable bowel syndrome
2. 変形性関節症の初回薬物療法 initial pharmacologic therapy of osteoarthritis
3. クリンダマイシン：概要 clindamycin an overview
4. 成人における急性咽頭炎の対症療法 symptomatic treatment of acute pharyngitis in adults
5. 慢性非アレルギー性鼻炎 chronic nonallergic rhinitis

Progressive facilitation of antegrade conduction via an accessory pathway in a patient with Wolff-Parkinson-White syndrome and permanent atrial fibrillation.

Takahashi N, Ooie T, Nakagawa M, Hara M, Saikawa T, Yoshimatsu H.SourceDepartment of Internal Medicine 1, Oita University, Japan.
Internal medicine (Tokyo, Japan).Intern Med.2005 Dec;44(12):1264-8.
The case of a 64-year-old man with Wolff-Parkinson-White syndrome and permanent atrial fibrillation (AF) is reported. The patient was admitted due to electrocardiographic feature of AF with rapid conduction over the left-sided accessory pathway. Administration of pirmenol effectively suppressed the
PMID 16415547

Appropriate dosing of antiarrhythmic drugs in Japan requires therapeutic drug monitoring.

Takada M, Goto T, Kotake T, Saito M, Kawato N, Nakai M, Gunji T, Shibakawa M.SourceDepartment of Pharmacy, National Cardiovascular Center, Suita-city, Osaka, Japan. takada@hsp.ncvc.go.jp
Journal of clinical pharmacy and therapeutics.J Clin Pharm Ther.2005 Feb;30(1):5-12.
OBJECTIVE: In general, drugs are used in accordance with an approved dosage regimen in expectation of an appropriate balance between efficacy and toxicity. However, dose control of drugs with a narrow therapeutic range and marked intersubject variability in pharmacokinetics should be established thr
PMID 15658999

安部治彦,沼田哲也,花田秀幸,合志清隆,中島康秀
産業医科大学雑誌 20(4), 339-343, 1998-12-01
塩酸ピルメノールは,上室性・心室性頻脈性不整脈に対する新しい経口抗不整脈剤である。我々は,他剤抵抗性の発作性心房細動を有する女性患者に対し,塩酸ピルメノール経口投与を行ったが,投与後初期に著明な心電図上QT延長とT波の陰転化を再現性をもって来たした稀な症例を経験した。塩酸ピルメノールの血中濃度は治療濃度以下であり,リンパ球刺激試験は陽性であった。塩酸ピルメノール経口投与後初期に著明なQT延長とT波 …
NAID 110001259976