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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/24 01:58:18」(JST)

English Journal

Noninvasive monitoring of Pirenoxine Sodium concentration in aqueous humor based on dual-wavelength iris imaging technique.

Zhou Y, Hu Y, Zeng N, Ji Y, Dai X, Li P, Ma H, He Y.AbstractWe present a noninvasive method of detecting substance concentration in the aqueous humor based on dual-wavelength iris imaging technology. Two light sources, one centered within (392 nm) and the other centered outside (850 nm) of an absorption band of Pirenoxine Sodium, a common type of drugs in eye disease treatment, were used for dual-wavelength iris imaging measurement. After passing through the aqueous humor twice, the back-scattering light was detected by a charge-coupled device (CCD). The detected images were then used to calculate the concentration of Pirenoxine Sodium. In eye model experiment, a resolution of 0.6525 ppm was achieved. Meanwhile, at least 4 ppm can be distinguished in in vivo experiment. These results demonstrated that our method can measure Pirenoxine Sodium concentration in the aqueous humor and its potential ability to monitor other materials' concentration in the aqueous humor.
Biomedical optics express.Biomed Opt Express.2011 Jan 5;2(2):231-42.
We present a noninvasive method of detecting substance concentration in the aqueous humor based on dual-wavelength iris imaging technology. Two light sources, one centered within (392 nm) and the other centered outside (850 nm) of an absorption band of Pirenoxine Sodium, a common type of drugs in ey
PMID 21339869

Ditopic complexation of selenite anions or calcium cations by pirenoxine: an implication for anti-cataractogenesis.

Liao JH, Chen CS, Hu CC, Chen WT, Wang SP, Lin IL, Huang YH, Tsai MH, Wu TH, Huang FY, Wu SH.SourceInstitute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan.
Inorganic chemistry.Inorg Chem.2011 Jan 3;50(1):365-77. Epub 2010 Dec 7.
This study investigated whether and how pirenoxine (PRX) interacts with selenite or calcium ions, as these two ions have been proven respectively a factor leading to the formation of lens cataract. UV, NMR, and isothermal titration calorimetry (ITC) analysis indicated that PRX could bind maximum up
PMID 21138325

Preventive Effect of Eye Drops of Liposomes Containing Disulfiram and Cefmetazole on Selenite-Induced Cataract in Rat Pups

ITO Yoshimasa,NAGAI Noriaki,CAI Hong,TAKEDA Maki,KOIZUMI Yuichi
Journal of Oleo Science 55(1), 15-22, 2006
… Disulfiram (DSF) and cefmetazole (CMZ), which possess with anti-oxidative activities were tested for anti-cataract effect in rats and were compared with pirenoxine (PRX), which is a marketed product used for the treatment of cataract. …
NAID 130000055608

河嶋洋一,桑野光明,太田淳稔
Drug delivery system 14(6), 480-484, 1999-11-10
… Pirenoxine ophthalmic solution was developed based on the quinoid theory which is one of the theories for development mechanism of senile cataracts, and its usefulness for treatment of cataracts has been proved. … Since pirenoxine is unstable in aqueous solution, conventional products are required the reconstitution procedure of tablet (or granule) with accompanied solvent before use. … Under these circumstances, one bottle type and stable pirenoxine ophthalmic product has been desired. …
NAID 10007339000

リンク元

Systematic (IUPAC) name
	1,5-Dioxo-4H-pyrido[3,2-a]phenoxazine-3-carboxylic acid
Clinical data
Trade names	Catalin
Identifiers
CAS Number	1043-21-6
ATCvet code	QS01XA91
PubChem	CID: 4846
ChemSpider	4846
UNII	27L0EP6IZK
Chemical data
Formula	C16H8N2O5
Molecular mass	308.24512 g/mol
	SMILES C1=CC=C2C(=C1)N=C3C(=CC(=O)C4=C3C(=O)C=C(N4)C(=O)O)O2 ;
	InChI InChI=1S/C16H8N2O5/c19-9-5-8(16(21)22)18-14-10(20)6-12-15(13(9)14)17-7-3-1-2-4-11(7)23-12/h1-6H,(H,18,19)(H,21,22) ; Key:OKPNYGAWTYOBFZ-UHFFFAOYSA-N ;