phosphatidyl-N-methylethanolamine N-methyltransferase

ホスファチジル-N-メチルエタノールアミン-N-メチル基転移酵素、ホスファチジル-N-メチルエタノールアミン-N-メチルトランスフェラーゼ

WordNet

1. the 14th letter of the Roman alphabet (同)n

PrepTutorEJDIC

1. nitrogenの化学記号
2. neodymiumの化学記号

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/01/04 09:23:52」(JST)

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[Wiki en表示]

phosphatidyl-N-methylethanolamine N-methyltransferase
Identifiers
EC number	2.1.1.71
CAS number	67167-73-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a phosphatidyl-N-methylethanolamine N-methyltransferase (EC 2.1.1.71) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine S-adenosyl-L-homocysteine + phosphatidyl-N-dimethylethanolamine

Thus, the two substrates of this enzyme are S-adenosyl methionine and phosphatidyl-N-methylethanolamine, whereas its two products are S-adenosylhomocysteine and phosphatidyl-N-dimethylethanolamine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:phosphatidyl-N-methylethanolamine N-methyltransferase. Other names in common use include phosphatidylmonomethylethanolamine methyltransferase, methyltransferase II, phospholipid methyltransferase, PLMT, phosphatidyl-N-methylethanolamine methyltransferase, phosphatidyl-N-monomethylethanolamine methyltransferase, phosphatidylethanolamine methyltransferase I, and phosphatidylmonomethylethanolamine methyltransferase. This enzyme participates in glycine, serine and threonine metabolism and glycerophospholipid metabolism.

References

• Hirata F, Viveros OH, Diliberto EJ Jr, Axelrod J (1978). "Identification and properties of two methyltransferases in conversion of phosphatidylethanolamine to phosphatidylcholine". Proc. Natl. Acad. Sci. U.S.A. 75 (4): 1718–21. doi:10.1073/pnas.75.4.1718. PMC 392410. PMID 25437. 
• Schneider WJ, Vance DE (1979). "Conversion of phosphatidylethanolamine to phosphatidylcholine in rat liver. Partial purification and characterization of the enzymatic activities". J. Biol. Chem. 254 (10): 3886–91. PMID 438165. 

UpToDate Contents

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• 1. クレアチン代謝の先天性疾患congenital disorders of creatine metabolism [show details]
  …creatine. They are arginine:glycine amidinotransferase (AGAT) deficiency and guanidinoacetate methyltransferase (GAMT) deficiency The third disorder, X-linked creatine transporter (CRTR) deficiency, is caused …
• 2. 成人における抗癌剤の投与dosing of anticancer agents in adults [show details]
  …practice. The subject of irinotecan dosing is discussed further elsewhere. Thiopurine S-methyltransferase (TPMT) is responsible for the metabolism of thiopurines, which includes 6-mercaptopurine [6-MP] …
• 3. 膠芽腫の診断を受けたばかりの成人への治療およびその予後treatment and prognosis of newly diagnosed glioblastoma in adults [show details]
  …1 or type 2 mutations (particularly in patients <55 years of age) and O6-methylguanine-DNA methyltransferase (MGMT) promotor methylation, when possible. Methods of testing are reviewed separately. While …
• 4. 抗リン脂質抗体症候群の発症機序pathogenesis of antiphospholipid syndrome [show details]
  …factor, and via impaired fibrinolysis . aPL may mediate effects via signaling pathways such as phosphatidyl-inositol 3-kinase/AKT pathway . In addition to heightening the risk of vascular thrombosis,…
• 5. IDH変異と1p／19q共欠損のある乏突起神経膠腫の臨床的特徴、診断、病理clinical features diagnosis and pathology of idh mutant 1p 19q codeleted oligodendrogliomas [show details]
  …and have the CpG island hypermethylated phenotype (CIMP), in which the O6-methylguanine-DNA methyltransferase (MGMT) promoter region as a rule is also methylated. MGMT promotor methylation should be assessed …

English Journal

• Roles of phospholipid methyltransferases in pycnidia development, stress tolerance and secondary metabolism in the taxol-producing fungus Pestalotiopsis microspore.

• Akhberdi O, Zhang Q, Wang H, Li Y, Chen L, Wang D, Yu X, Wei D, Zhu X.
• Microbiological research. 2018 May;210()33-42.
• Phosphatidylcholine (PC) is an important membrane component of the eukaryotic cell. In yeast fungi, two phospholipid methyltransferases catalyze consecutive steps of methylation in the formation of phosphatidylcholine from phosphatidylethanolamine. However, roles of phospholipid methyltransferases i
• PMID 29625656

• Petit-High Pressure Carbon Dioxide stress increases synthesis of S-Adenosylmethionine and phosphatidylcholine in yeast Saccharomyces cerevisiae.

• Niu L, Nomura K, Iwahashi H, Matsuoka H, Kawachi S, Suzuki Y, Tamura K.
• Biophysical chemistry. 2017 Dec;231()79-86.
• Petit-High Pressure Carbon Dioxide (p-HPCD) is a promising nonthermal technology for foods pasteurization. Cluster analysis of gene expression profiles of Saccharomyces cerevisiae exposed to various stresses exhibited that gene expression profile for p-HPCD stress (0.5MPa, 25°C) was grouped into a
• PMID 28314628

• Membrane-binding mechanism of a bacterial phospholipid N-methyltransferase.

• Danne L, Aktas M, Gleichenhagen J, Grund N, Wagner D, Schwalbe H, Hoffknecht B, Metzler-Nolte N, Narberhaus F.
• Molecular microbiology. 2015 Jan;95(2)313-31.
• The membrane lipid phosphatidylcholine (PC) is crucial for stress adaptation and virulence of the plant pathogen Agrobacterium tumefaciens. The phospholipid N-methyltransferase PmtA catalyzes three successive methylations of phosphatidylethanolamine to yield PC. Here, we asked how PmtA is recruited
• PMID 25403021

Related Links

• Phosphatidyl-N-methylethanolamine N-methyltransferase

Phosphatidyl-N-methylethanolamine N-methyltransferase Gene PLMT Organism Arabidopsis thaliana (Mouse-ear cress) Status Reviewed-Annotation score: -Experimental evidence at transcript level i Function i Catalyzes the , , , ...

• KEGG ENZYME: 2.1.1.71

phosphatidyl-N-methylethanolamine N-methyltransferase; phosphatidylmonomethylethanolamine methyltransferase; methyltransferase II; phospholipid methyltransferase; PLMT; phosphatidyl-N-methylethanolamine methyltransferase;

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★リンクテーブル★

リンク元	「ホスファチジル-N-メチルエタノールアミン-N-メチル基転移酵素」「ホスファチジル-N-メチルエタノールアミン-N-メチルトランスフェラーゼ」
関連記事	「n」「methyltransferase」「N」「phosphatidyl」「methyltransferases」

「ホスファチジル-N-メチルエタノールアミン-N-メチル基転移酵素」

　　[★]

英

phosphatidyl-N-methylethanolamine N-methyltransferase

関

ホスファチジル-N-メチルエタノールアミン-N-メチルトランスフェラーゼ

「ホスファチジル-N-メチルエタノールアミン-N-メチルトランスフェラーゼ」

　　[★]

英

phosphatidyl-N-methylethanolamine N-methyltransferase

関

ホスファチジル-N-メチルエタノールアミン-N-メチル基転移酵素

「n」

　　[★]

• n.

• 例数

関

number of experiment、sample size

• pの前の[n]はmと記載する。synptom→symptom

「methyltransferase」

　　[★] メチルトランスフェラーゼ、メチル基転移酵素、メチル化酵素

「N」

　　[★]

• アスパラギン asparagine
• 窒素(原子、分子)

　 　

「phosphatidyl」

　　[★]

ホスファチジル、フォスファチジル

「methyltransferases」

　　[★] メチルトランスフェラーゼ