WordNet

a constant in the equation of a curve that can be varied to yield a family of similar curves (同)parametric quantity
a quantity (such as the mean or variance) that characterizes a statistical population and that can be estimated by calculations from sample data
any factor that defines a system and determines (or limits) its performance
the study of the action of drugs in the body: method and rate of excretion; duration of effect; etc.

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1. テトラサイクリン tetracyclines
2. ステロイドの中断 glucocorticoid withdrawal
3. 三叉神経痛 trigeminal neuralgia
4. パーキンソン病に対する神経保護療法 neuroprotective therapy for parkinson disease
5. 妊娠期間および出産予定日の出生前評価 prenatal assessment of gestational age and estimated date of delivery

Impact of imipenem and amikacin pharmacokinetic/pharmacodynamic parameters on microbiological outcome of Gram-negative bacilli ventilator-associated pneumonia.

Pajot O1, Burdet C2, Couffignal C2, Massias L3, Armand-Lefevre L4, Foucrier A5, Da Silva D5, Lasocki S6, Laouénan C2, Mentec H7, Mentré F2, Wolff M8.
The Journal of antimicrobial chemotherapy.J Antimicrob Chemother.2015 May;70(5):1487-94. doi: 10.1093/jac/dku569. Epub 2015 Jan 27.
OBJECTIVES: Despite recent advances, antibiotic therapy of ventilator-associated pneumonia (VAP) in ICU patients is still challenging. We assessed the impact of imipenem and amikacin pharmacokinetic and pharmacodynamic parameters on microbiological outcome in these patients.PATIENTS AND METHODS: Pat
PMID 25630642

Dynamic contrast-enhanced MRI in mice: An investigation of model parameter uncertainties.

Rukat T1, Walker-Samuel S, Reinsberg SA.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine.Magn Reson Med.2015 May;73(5):1979-87. doi: 10.1002/mrm.25319. Epub 2014 Jul 22.
PURPOSE: To establish the experimental factors that dominate the uncertainty of hemodynamic parameters in commonly used pharmacokinetic models.METHODS: By fitting simulation results from a multiregion tissue exchange model (Multiple path, Multiple tracer, Indicator Dilution, 4 region), the precision
PMID 25052296

Integrating dynamic mixed-effect modelling and penalized regression to explore genetic association with pharmacokinetics.

Bertrand J1, De Iorio M, Balding DJ.
Pharmacogenetics and genomics.Pharmacogenet Genomics.2015 May;25(5):231-8. doi: 10.1097/FPC.0000000000000127.
CONTEXT: In a previous work, we have shown that penalized regression approaches can allow many genetic variants to be incorporated into sophisticated pharmacokinetic (PK) models in a way that is both computationally and statistically efficient. The phenotypes were the individual model parameter esti
PMID 25751396

Nakashima Shoko,Yamamoto Katsuhiko,Arai Yuta,Ikeda Yukihiro
Chemical and Pharmaceutical Bulletin 61(12), 1228-1238, 2013
… Aqueous solubility is an important parameter in the successful development of oral dosage formulation since poor aqueous solubility limits absorption. … By using the physicochemical profiling results of 75 anti-cancer drugs and clinical candidates, we examined the relationship between thermodynamic solubility and molecular structural parameters and assessed the effects of thermodynamic solubility on pharmacokinetic profile for rational soluble drug design. …
NAID 130003381785

What is the reason why does mizoribine ineffectiveness for the patient with steroid―resistant nephrotic syndrome?

詫間章俊,阿部祥英,冨家俊弥,日比野聡,星野顕宏,齋藤多賀子,三川武志,櫻井俊輔,渡邉修一郎,佐藤均,村山純一郎,板橋家頭夫
Nihon Shoni Jinzobyo Gakkai Zasshi 25(1), 35-41, 2012
We report the case of a 3―year―old female patient with steroid―resistant nephrotic syndrome. Although mizoribine (MZR) was administered at a dose of 9.5 mg/kg body weight/day, the peak MZR serum conc …
NAID 130003346829