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1. 移植免疫transplantation immunobiology [show details]
… at the amino terminus. Structurally, this region is comprised of a platform of beta-pleated sheet that supports two parallel strands of alpha-helix, which together form the peptide-binding groove. Class-I …
2. βサラセミアの病態生理pathophysiology of beta thalassemia [show details]
… manifestations of severe thalassemia. Beta⁺ thalassemia refers to mutations that cause decreased (but not absent) beta globin production. Patients who are homozygous for beta⁺ thalassemia mutations …
3. 膵β細胞の機能pancreatic beta cell function [show details]
…acids that is synthesized, packaged, and secreted in pancreatic beta cells. The mechanisms of insulin secretion and measurements of beta cell function in normal subjects and patients with various diseases …
4. β遮断剤の主な副作用major side effects of beta blockers [show details]
… Most of the major adverse effects of beta blocking drugs result from beta-adrenoreceptor blockade. Many signs and symptoms can therefore be induced because the beta receptors affect multiple metabolic and …
5. 基質特異性拡張型β-ラクタマーゼextended spectrum beta lactamases [show details]
…often cause are discussed elsewhere. Beta-lactamases are enzymes that open the beta-lactam ring, inactivating the antibiotic. The first plasmid-mediated beta-lactamase in gram-negative bacteria was …

Japanese Journal

Highlighted Paper selected by Editor-in-Chief : Simulation Study on Complex Conformations of Aβ₄₂ Peptides on a GM1 Ganglioside-Containing Lipid Membrane

Vahed Majid,Neya Saburo,Matsuzaki Katsumi,Hoshino Tyuji
ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 66(2), 170-177, 2018
… Aggregation and complex formation of amyloid beta (Aβ) peptides on a neuronal cell membrane is a hallmark of neuro-disturbance diseases. … In this work, we performed molecular dynamics (MD) simulations to investigate the initial stage of interactions of multiple Aβ42 … Conformational changes of Aβs due to adhesion on the membrane and subsequent molecular interactions among the Aβs were monitored. …
NAID 130006328084

Secondary-structure prediction revisited: Theoretical β-sheet propensity and coil propensity represent structures of amyloids and aid in elucidating phenomena involved in interspecies transmission of prions

Taguchi Yuzuru,Nishida Noriyuki
PLOS ONE 12(2), e0171974, 2017-02-15
… Recently hypothesized models consist solely of β- sheets and intervening loops/kinks; … i.e. parallel in-register β-sheet and β-solenoid models. … We therefore used the theoretical values of β-sheet (Pβ) and random-coil (Pc) propensity calculated by secondary structure prediction with a neural network, to analyze interspecies transmission of prions. …
NAID 120006221088

グリシン，ジグリシン，トリグリシンを含む脂肪酸誘導体によるポリグリシンII構造の形成

野田卓夢,近藤沙南,荷堂清香 [他],長谷川健,山田哲弘
高分子論文集 73(1), 69-75, 2016
グリシン，ジグリシン，トリグリシンを部分構造とする脂肪酸型両親媒性分子を合成し，固体試料のFT-IRスペクトルを測定した．これらの化合物は，いずれもアミドI吸収帯が1650 cm－1と1640 cm－1に分裂する典型的なポリグリシンII構造(31</s …
NAID 130005120381

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We reveal that the fibril-forming solution of HEWL has the capability to form fibril and oligomer with distinct β-sheet configurations under different temperatures. Amyloid fibril with parallel β-sheet configuration is formed at elevated

Parallel Beta-Sheet - an overview | ScienceDirect Topics

They are of two kinds: parallel and antiparallel. An example of a parallel β-sheet is shown in Figure 2.5, where the amino acids of two tetrapeptides adopt values for Φ and Ψ in the vicinity of −110 and +120 , respectively (2).These two ...