paired helical filaments

対らせん状細線維 PHF

WordNet

1. form a pair or pairs; "The two old friends paired off" (同)pair off, partner off, couple
2. a set of two similar things considered as a unit (同)brace
3. a poker hand with 2 cards of the same value
4. two people considered as a unit
5. arrange in pairs; "Pair these numbers" (同)geminate
6. occur in pairs (同)geminate
7. the stalk of a stamen
8. a thin wire (usually tungsten) that is heated white hot by the passage of an electric current
9. a threadlike structure (as a chainlike series of cells) (同)filum
10. mated sexually

PrepTutorEJDIC

1. (二つで一つに用いられる物の)『組』,『対』《+『of』+『名』》 / (対になる部分からなる物の)『1個』《+『of』+『名』》 / 《集合的に》《複数扱い》夫婦,婚約中の男女;(動物の)つがい《+『of』+『名』》 / 《集合的に》《複数扱い》(同種または何かの関係のある物の)二人(二つ,2頭など)の組《+『of』+『名』》 / …‘を'二人(2個)ずつ組にする《+『名』+『off』(『up』),+『off』(『up』)+『名』》,(…と)…‘を'組にする《+『名』+『with』+『名』》 / (…と)…‘を'結婚させる《+『名』+[『up』]『with』+『名』》 / 二人(2個)ずつ組になる《+『off』(『up』)》
2. (くもの巣などの)細糸 / (電球・真空管内の)フィラメント
3. らせん形の

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• Alzheimer's disease drug development based on Computer-Aided Drug Design.

• Zeng H1, Wu X2.
• European journal of medicinal chemistry.Eur J Med Chem.2016 Oct 4;121:851-63. doi: 10.1016/j.ejmech.2015.08.039. Epub 2015 Sep 3.
• Alzheimer's disease (AD) is a common neurodegenerative disorder characterized by the excessive deposition of amyloids in the brain. The pathological features mainly include the extracellular amyloid plaques and intracellular neurofibrillary tangles, which are the production of amyloid precursor prot
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• E-pharmacophore-based virtual screening to identify GSK-3β inhibitors.

• Natarajan P1, Priyadarshini V1, Pradhan D1, Manne M1, Swargam S1, Kanipakam H1, Bhuma V2, Amineni U1.
• Journal of receptor and signal transduction research.J Recept Signal Transduct Res.2016 Oct;36(5):445-58. doi: 10.3109/10799893.2015.1122043. Epub 2015 Dec 20.
• Glycogen synthase kinase-3β (GSK-3β) is a serine/threonine kinase which has attracted significant attention during recent years in drug design studies. The deregulation of GSK-3β increased the loss of hippocampal neurons by triggering apoptosis-mediating production of neurofibrillary tangles and
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• Combs B1, Hamel C2, Kanaan NM3.
• Neurobiology of disease.Neurobiol Dis.2016 Oct;94:18-31. doi: 10.1016/j.nbd.2016.05.016. Epub 2016 May 31.
• Conformational changes involving the amino terminus of the tau protein are among the earliest alterations associated with tau pathology in Alzheimer's disease and other tauopathies. This region of tau contains a phosphatase-activating domain (PAD) that is aberrantly exposed in pathological forms of
• PMID 27260838

Japanese Journal

• Flavonoids Inhibit Heparin-Induced Aggregation of the Third Repeat (R3) of Microtubule-Binding Domain of Alzheimer's Tau Protein

• Bulletin of the Chemical Society of Japan 83(8), 911-922, 2010
• NAID 130004152787

• The biochemical study on the etiology of Alzheimer's disease

• Proceedings of the Japan Academy, Series B 86(1), 54-61, 2010
• NAID 130000149633

• 長寿医療の最前線　　アルツハイマー病：ベッドサイドからベンチへ

• 医療 60(12), 752-759, 2006
• NAID 130004316597

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★リンクテーブル★

リンク元	「対らせん状細線維」
関連記事	「pair」「helical」「filament」「paired」

「対らせん状細線維」

　　[★]

英

paired helical filaments, PHF

関

アルツハイマー病、アルツハイマー神経原線維変化

• アミロイド斑と神経原線維のもつれの結果認められる線維。神経原線維変化
• アルツハイマー病 の最も初期の病理的変化
• タウ蛋白が認められる。

「pair」

　　[★]

• n.
• vt.vi

• 一対にする/なる。(2人・2つを)組み合わせる、(2つが)組む。結婚させる/する、(動物を)つがわせる。(動物が)つがう。

Classical conditioning is used to pair a maladaptive but pleasurable stimulus with an aversive or painful stimulus so that the two become associated.

　 　 　 　 　 　 　

「helical」

　　[★]

• adj.

• らせんの、らせん状の、ヘリカルな、ヘリックスの

関

helices、helix、spiral

　

「filament」

　　[★]

• n.

• フィラメント、線維、繊維、微細線維、細糸

　 　 　 　

「paired」

　　[★]

• adj.

• 対での、ペアード

関

pair、pairwise、versus、vs