WordNet

a form of penicillin resistant to penicillinase and effective against penicillin-resistant staphylococci

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/09/01 18:37:53」(JST)

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Oxacillin sodium (trade name Bactocill) is a narrow spectrum beta-lactam antibiotic of the penicillin class.

It was developed by Beecham.^[1]

Uses

Oxacillin is a penicillinase-resistant β-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Another related compound is nafcillin. Since it is resistant to penicillinase enzymes, such as that produced by Staphylococcus aureus, it is widely used clinically in the US to treat penicillin-resistant Staphylococcus aureus. However, with the introduction and widespread use of both oxacillin and methicillin, antibiotic-resistant strains called oxacillin-resistant Staphylococcus aureus (MRSA/ORSA) have become increasingly prevalent worldwide.

Adverse effects

Further information: Penicillin drug reaction

Side effects include hypersensitivity and local reactions. In high doses, renal, hepatic, or nervous system effects can occur.^[2]

References

^ David Greenwood (2008). Antimicrobial drugs: chronicle of a twentieth century medical triumph. Oxford University Press US. pp. 124–. ISBN 978-0-19-953484-5. http://books.google.com/books?id=i4_FZHmzjzwC&pg=PA124. Retrieved 18 November 2010.
^ Drugs.com: Bactocill

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UpToDate Contents

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1. セレウス菌およびその他の非炭疽菌バシラス属 bacillus cereus and other non anthracis bacillus species
2. 成人における黄色ブドウ球菌菌血症の治療 treatment of staphylococcus aureus bacteremia in adults
3. 線状IgA水疱性皮膚症 linear iga bullous dermatosis
4. 小児におけるメチシリン耐性黄色ブドウ球菌による皮膚軟部組織の感染が疑われる患者の
評価およびマネージメント evaluation and management of suspected methicillin resistant staphylococcus aureus skin and soft tissue infections in children
5. ペニシリン penicillins

English Journal

The Posttranslocational Chaperone Lipoprotein PrsA Is Involved in both Glycopeptide and Oxacillin Resistance in Staphylococcus aureus.

Jousselin A, Renzoni A, Andrey DO, Monod A, Lew DP, Kelley WL.SourceService of Infectious Diseases, University Hospital and Medical School of Geneva, Geneva, Switzerland.
Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2012 Jul;56(7):3629-40. Epub 2012 Apr 23.
Understanding in detail the factors which permit Staphylococcus aureus to counteract cell wall-active antibiotics is a prerequisite to elaborating effective strategies to prolong the usefulness of these drugs and define new targets for pharmacological intervention. Methicillin-resistant S. aureus (M
PMID 22526301

Biochemical and Genetic Characterization of Carbapenem-Hydrolyzing β-Lactamase OXA-229 from Acinetobacter bereziniae.

Bonnin RA, Ocampo-Sosa AA, Poirel L, Guet-Revillet H, Nordmann P.SourceService de Bactériologie-Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine et Université Paris-Sud, K.-Bicêtre.
Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2012 Jul;56(7):3923-7. Epub 2012 Apr 16.
Acinetobacter bereziniae (formerly Acinetobacter genomospecies 10) isolate Nec was recovered from a skin sample of a patient hospitalized in Paris, France. It was resistant to penicillins, penicillin-inhibitor combinations, and carbapenems. Cloning and expression in Escherichia coli identified the c
PMID 22508298

Japanese Journal

血液培養における Oxacillin 低感受性MRSAの検索とその症例からの考察

仲間美香,照屋真利子,中村梢,儀間久美子,宮里博子,大田茂,山里香代,大田英也
医学検査 : 日本臨床衛生検査技師会誌 = The Japanese journal of medical technology 59(6), 778-781, 2010-06-25
NAID 10027748880

Antibacterial and synergistic effects of Smallanthus sonchifolius leaf extracts against methicillin-resistant Staphylococcus aureus under light intensity

JOUNG Hee,KWON Dong-Yeul,CHOI Jang-Gi,SHIN Dong-Young,CHUN Soon-Sil,YU Young-Beob,SHIN Dong-Won
Journal of natural medicines 64(2), 212-215, 2010-05-20
NAID 10027709622

Related Pictures

Oxacillin Injection : Uses, Side Effects, Interactions, Pictures, Warnings & Dosing Oxacillin for Injection — AuroMedics Pharma LLC

★リンクテーブル★

リンク元	「オキサシリン」
拡張検索	「cloxacillin benzathine」「dicloxacillin sodium」

「オキサシリン」

Oxacillin
Systematic (IUPAC) name
	(2S,5R,6R)-3,3-dimethyl-6-[(5-methyl-3-phenyl-; 1,2-oxazole-4-carbonyl)amino]-7-oxo-4-thia-1-; azabicyclo[3.2.0]heptane-2-carboxylic acid
Clinical data
Trade names	Bactocill
AHFS/Drugs.com	monograph
MedlinePlus	a685020
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	66-79-5
ATC code	J01CF04 QJ51CF04
PubChem	CID 6098
DrugBank	DB00713
ChemSpider	5873
UNII	UH95VD7V76
KEGG	D08307
ChEBI	CHEBI:49566
ChEMBL	CHEMBL891
Chemical data
Formula	C19H19N3O5S
Mol. mass	401.436 g/mol
	SMILES O=C(O)[C@@H]3N4C(=O)[C@@H](NC(=O)c2c(onc2c1ccccc1Cl)C)[C@H]4SC3(C)C;
	InChI InChI=1S/C19H18ClN3O5S/c1-8-11(12(22-28-8)9-6-4-5-7-10(9)20)15(24)21-13-16(25)23-14(18(26)27)19(2,3)29-17(13)23/h4-7,13-14,17H,1-3H3,(H,21,24)(H,26,27)/t13-,14+,17-/m1/s1 ; Key:LQOLIRLGBULYKD-JKIFEVAISA-N ;
Physical data
Density	1.49 g/cm³
Boiling point	686.8 °C (1268 °F)
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