WordNet

a silvery soft waxy metallic element of the alkali metal group; occurs abundantly in natural compounds (especially in salt water); burns with a yellow flame and reacts violently in water; occurs in sea water and in the mineral halite (rock salt) (同)Na, atomic number 11

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ソジウム,ナトリウム(金属元素;化学記号はNa)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/27 10:27:07」(JST)

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Cloxacillin is an antibiotic useful for the treatment of a number of bacterial infections. It is semisynthetic and in the same class as penicillin.

Cloxacillin is used against staphylococci that produce beta-lactamase, due to its large R chain, which does not allow the beta-lactamases to bind. This drug has a weaker antibacterial activity than benzylpenicillin, and is devoid of serious toxicity except for allergic reactions.

Cloxacillin was discovered and developed by Beecham.^[1] It is sold under a number of trade names, including Cloxapen, Cloxacap, Tegopen and Orbenin. It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.^[2]

References

^ David Greenwood (2008). Antimicrobial drugs: chronicle of a twentieth century medical triumph. Oxford University Press US. pp. 124–. ISBN 978-0-19-953484-5. Retrieved 18 November 2010.
^ "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.

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1. メチシリン耐性黄色ブドウ球菌の皮膚・軟部組織感染症の疑い：生後29日以上の小児の評価とマネージメント suspected methicillin resistant staphylococcus aureus skin and soft tissue infections evaluation and management in children greater than28 days
2. ペニシリン、黄色ブドウ球菌用ペニシリン、広域ペニシリン penicillin antistaphylococcal penicillins and broad spectrum penicillins
3. 成人における骨髄炎の概要 overview of osteomyelitis in adults
4. 小児や青年の乳腺炎と乳房膿瘍 mastitis and breast abscess in children and adolescents
5. 敗血症性滑液包炎 septic bursitis

English Journal

Development and validation of an HPLC method for the determination of six penicillin and three amphenicol antibiotics in gilthead seabream (Sparus Aurata) tissue according to the European Union Decision 2002/657/EC.

Evaggelopoulou EN, Samanidou VF.SourceLaboratory of Analytical Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki 541 24, Greece.
Food chemistry.Food Chem.2013 Feb 15;136(3-4):1322-9. doi: 10.1016/j.foodchem.2012.09.044. Epub 2012 Sep 26.
A confirmatory high performance liquid chromatography method for the determination of six penicillin antibiotics and three amphenicol antibiotics in gilthead seabream (Sparus Aurata) tissue was developed. Ampicillin (AMP), penicillin G (PG), penicillin V (PV), oxacillin (OXA), cloxacillin (CLO), dic
PMID 23194530

Characteristics of patients with definite septic arthritis at Hamad General Hospital, Qatar: a hospital-based study from 2006 to 2011.

Khan FY, Abu-Khattab M, Baagar K, Mohamed SF, Elgendy I, Anand D, Malallah H, Sanjay D.SourceDepartment of Medicine, Hamad General Hospital, PO Box 3050, Doha, Qatar, fakhanqal@gmail.com.
Clinical rheumatology.Clin Rheumatol.2013 Feb 13. [Epub ahead of print]
The aim of this retrospective study was to determine the epidemiological and clinical characteristics, coexisting conditions, causative organisms, and outcomes of all adult patients 15 years of age or older who had definite septic arthritis at Hamad General Hospital, Qatar, from 2006 to 2011. Durin
PMID 23404237

Development of a Rapid Multi-residue Assay for Detecting β-lactams Using Penicillin Binding Protein 2x*.

Zeng K, Zhang J, Wang Y, Wang ZH, Zhang SX, Wu CM, Shen JZ.SourceDepartment of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Biomedical and environmental sciences : BES.Biomed Environ Sci.2013 Feb;26(2):100-9. doi: 10.3967/0895-3988.2013.02.004.
OBJECTIVE: To develop a rapid multi-residue assay for detecting 16 demanded by the European Union (EU).METHODS: A recombinant penicillin-binding protein (PBP) 2x* from Streptococcus pneumoniae R6 was expressed in vitro and six β-lactams were conjugated to HRP by four methods. A rapid multi-residue
PMID 23336133

Japanese Journal

Case of acute generalized exanthematous pustulosis caused by ampicillin/cloxacillin sodium in a pregnant woman

MATSUMOTO Yuka,OKUBO Yukari,YAMAMOTO Toshiyuki,ITO Tomonobu,TSUBOI Ryoji
Journal of dermatology 35(6), 362-364, 2008-06-01
NAID 10024297115

プレカラム蛍光誘導化法による食肉中残留ペニシリン系抗生物質の高速液体クロマトグラフィー分析

牛水徹,佐藤俊男,齋藤忠夫,伊藤敞敏
日本畜産學會報 = The Japanese journal of zootechnical science 72(10), 570, 2001-10-25
ウシおよびブタの筋肉および腎臓中に残留する可能性のあるペニシリン系抗生物質(PCs;ペニシリンG,オキサシリン,クロキサシリン,ジクロキサシリンおよびナフシリン)を蛍光誘導体化することにより,高感度に定性定量する分析法を開発した.7種の蛍光誘導体化試薬についてペニシリンGとの反応性を検討し,もっとも良好な結果の得られた1-プロモアセチルピレンを選択した.筋肉および腎臓試料の水抽出液を,硫酸およびタ …
NAID 10025835384

Fast Atom Bombardment Mass Spectrometry of Isoxazolylpenicillins and Their Metabolites in Man

村井靖夫,中川照眞,宇野豊三
Chemical & pharmaceutical bulletin 33(1), 383-387, 1985-01-25
… All the substances gave positive pseudomolecular ions, as either proton adducts or sodium ion adducts, and some structurally significant fragment ions. …
NAID 110003625147

Related Pictures

★リンクテーブル★

リンク元	「クロキサシリン」「cloxacillin benzathine」
拡張検索	「flucloxacillin sodium」「dicloxacillin sodium」

「クロキサシリン」

Cloxacillin
Systematic (IUPAC) name
	(2S,5R,6R)-6-{[3-(2-chlorophenyl)-5-methyl-; oxazole-4-carbonyl]amino}-3,3-dimethyl-7-oxo-; 4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Clinical data
Trade names	Cloxapen
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy; category	US: B (No risk in non-human studies);
Routes of; administration	Oral, IM
Pharmacokinetic data
Bioavailability	37 to 90%
Protein binding	95%
Half-life	30 minutes to 1 hour
Excretion	Renal and biliary
Identifiers
CAS Registry Number	61-72-3
ATC code	J01CF02 QJ51CF02 QS01AA90
PubChem	CID 6098
DrugBank	DB01147
ChemSpider	5873
UNII	O6X5QGC2VB
KEGG	D07733
ChEBI	CHEBI:49566
ChEMBL	CHEMBL891
Chemical data
Formula	C19H18ClN3O5S
Molecular mass	435.88 g/mol
	SMILES O=C(O)[C@@H]3N4C(=O)[C@@H](NC(=O)c2c(onc2c1ccccc1Cl)C)[C@H]4SC3(C)C;
	InChI InChI=1S/C19H18ClN3O5S/c1-8-11(12(22-28-8)9-6-4-5-7-10(9)20)15(24)21-13-16(25)23-14(18(26)27)19(2,3)29-17(13)23/h4-7,13-14,17H,1-3H3,(H,21,24)(H,26,27)/t13-,14+,17-/m1/s1 ; Key:LQOLIRLGBULYKD-JKIFEVAISA-N ;
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