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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/04/15 20:37:19」(JST)

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Orotidine 5'-monophosphate (OMP), also known as orotidylic acid, is a pyrimidine nucleotide which is the last intermediate in the biosynthesis of uridine monophosphate. OMP is formed from orotate and phosphoribosyl pyrophosphate by the enzyme Orotate phosphoribosyltransferase

In humans, the enzyme UMP synthase converts OMP into uridine 5'- monophosphate. If UMP synthase is defective, orotic aciduria can result.

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English Journal

Physiological characterization of a pyrimidine auxotroph exposes link between uracil phosphoribosyltransferase regulation and riboflavin production in Ashbya gossypii.

Silva R, Aguiar TQ, Oliveira C, Domingues L.
New biotechnology. 2019 May;50()1-8.
The blockage of the de novo pyrimidine biosynthetic pathway at the orotidine-5'-phosphate decarboxylase level was previously demonstrated to affect riboflavin production in the industrial producer fungus Ashbya gossypii. However, the molecular basis for the unusual sensitivity to uracil displayed by
PMID 30590201

First case report of cryptococcosis due to Cryptococcus decagattii in a pediatric patient in Argentina.

Berejnoi A, Taverna CG, Mazza M, Vivot M, Isla G, Córdoba S, Davel G.
Revista da Sociedade Brasileira de Medicina Tropical. 2019 Mar;52()e20180419.
We report the first case of cryptococcosis due to Cryptococcus decagattii in an immunocompetent pediatric patient from an indigenous community in Argentina with a successful outcome. Two isolates (blood, cerebrospinal fluid) were genotyped by restriction fragment length polymorphism of the orotidine
PMID 30942260

The pyrimidine biosynthetic pathway and its regulation in Pseudomonas jessenii.

Murahari EC, West TP.
Antonie van Leeuwenhoek. 2019 Mar;112(3)461-469.
The control of the pyrimidine biosynthetic pathway by pyrimidine bases was examined in Pseudomonas jessenii ATCC 700870. The pyrimidine biosynthetic enzymes aspartate transcarbamoylase, dihydroorotase, dihydroorotate dehydrogenase, orotate phosphoribosyltransferase, and orotidine 5'-monophosphate (O
PMID 30251112

Related Pictures

Anatomy of a proficient enzyme: The structure of orotidine 5 Orotidine Monophosphate Decarboxylase, J. K. Lee | 9783540205661 Structures of the Human Orotidine-5′-Monophosphate Decarboxylase Support a Covalent Orotidine 5′-monophosphate trisodium salt | CAS 68244-58-6 | SCBT - Santa Cruz Orotidine >=90%HPLC | 314-50-1 | Sigma-Aldrich Orotidine -5-Monophosphate Decarboxylase Crystal Structures of Orotidine Monophosphate Decarboxylase: Does the One-pot multienzymatic synthesis of pyrimidine nucleosides | Download Scientific

★リンクテーブル★

リンク元	「OMP」「オロチジン5'-一リン酸」
関連記事	「monophosphate」

「OMP」

Orotidine 5'-monophosphate
	IUPAC name 3-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl]-2,6-dioxo-pyrimidine-4-carboxylic acid
	Other names Orotidylic acid,; OMP
Identifiers
CAS number	2149-82-8
PubChem	968
MeSH	Orotidine+5'-monophosphate
Jmol-3D images	Image 1
	SMILES C1=C(N(C(=O)NC1=O)C2C(C(C(O2)COP(=O)(O)O)O)O)C(=O)O ;
Properties
Molecular formula	C10H13N2O11P
Molar mass	368.191 g/mol
	(verify) (what is: /?); Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
	Infobox references

　　[★]

「オロチジン5'-一リン酸」

　　[★]

英: orotidine 5'-phosphate, orotidine monophosphate OMP

「monophosphate」

　　[★]

n.

一リン酸塩、一リン酸エステル、一リン酸

匿名

検索

案内

案内

orotidine monophosphate