WordNet

small room in which a monk or nun lives (同)cubicle
a device that delivers an electric current as the result of a chemical reaction (同)electric cell
a room where a prisoner is kept (同)jail cell, prison cell
(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
any small compartment; "the cells of a honeycomb"
a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
lacking any legal or binding force; "null and void" (同)void
malignant neoplasm of blood-forming tissues; characterized by abnormal proliferation of leukocytes; one of the four major types of cancer (同)leukaemia, leucaemia, cancer of the blood
the 13th letter of the Greek alphabet

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1. 急性骨髄性白血病の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of acute myeloid leukemia
2. 小児および思春期における急性リンパ芽球性白血病の症状および診断の概要 overview of the presentation and diagnosis of acute lymphoblastic leukemia in children and adolescents
3. 慢性リンパ性白血病に対する治療の概要 overview of the treatment of chronic lymphocytic leukemia
4. 急性骨髄性白血病の合併症の概要 overview of the complications of acute myeloid leukemia
5. 小児および思春期における急性リンパ芽球性白血病の治療の概要 overview of the treatment of acute lymphoblastic leukemia in children and adolescents

A new ATL xenograft model and evaluation of pyrrolidine dithiocarbamate as a potential ATL therapeutic agent.

Nakamura D1, Yoshimitsu M2, Kuroki A3, Hachiman M3, Kamada Y1, Ezinnne CC3, Arai A1, Inoue H4, Hamada H4, Hayashida M4, Suzuki S3, Fujino S4, Arima N4, Arima M4, Tabuchi T4, Okada S5, Arima N1.
Experimental hematology.Exp Hematol.2015 Jul 10. pii: S0301-472X(15)00512-3. doi: 10.1016/j.exphem.2015.06.303. [Epub ahead of print]
Adult T-cell leukemia/lymphoma (ATL) is caused by human T-lymphotrophic virus type-1 infection, and it is one of the most refractory malignant T cell lymphomas. Improvement of ATL therapy options requires the establishment of appropriate ATL animal models. In the present study, we successfully gener
PMID 26169955

Aspp1 Preserves Hematopoietic Stem Cell Pool Integrity and Prevents Malignant Transformation.

Yamashita M1, Nitta E2, Suda T3.
Cell stem cell.Cell Stem Cell.2015 Jul 2;17(1):23-34. doi: 10.1016/j.stem.2015.05.013. Epub 2015 Jun 25.
Quiescent hematopoietic stem cells (HSCs) are prone to mutagenesis, and accumulation of mutations can result in hematological malignancies. The mechanisms through which HSCs prevent such detrimental accumulation, however, are unclear. Here, we show that Aspp1 coordinates with p53 to maintain the gen
PMID 26119234

Modulation of glucocorticoid resistance in pediatric T-cell Acute Lymphoblastic Leukemia by increasing BIM expression with the PI3K/mTOR inhibitor BEZ235.

Hall CP1, Reynolds CP2, Kang MH3.
Clinical cancer research : an official journal of the American Association for Cancer Research.Clin Cancer Res.2015 Jun 16. pii: clincanres.0114.2015. [Epub ahead of print]
PURPOSE: The aim of our study is to evaluate the preclinical therapeutic activity and mechanism of action of BEZ235, a dual PI3K/mTOR inhibitor, in combination with dexamethasone in ALL.EXPERIMENTAL DESIGN: The cytotoxic effects of BEZ235 and dexamethasone as single agents and in combination were as
PMID 26080839