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Preactivated thiolated pullulan as a versatile excipient for mucosal drug targeting.

Leonaviciute G1, Suchaoin W1, Matuszczak B2, Lam HT1, Mahmood A1, Bernkop-Schnürch A3.
Carbohydrate polymers.Carbohydr Polym.2016 Oct 20;151:743-51. doi: 10.1016/j.carbpol.2016.06.005. Epub 2016 Jun 2.
AIM: The purpose of the present study was to generate a novel mucoadhesive thiolated pullulan with protected thiol moieties and to evaluate its suitability as mucosal drug delivery system.METHODS: Two different synthetic pathways: bromination-nucleophilic substitution and reductive amination includi
PMID 27474621

Multifunctional and High Affinity Polymer Ligand that Provides Bio-Orthogonal Coating of Quantum Dots.

Wang W1, Kapur A1, Ji X1, Zeng B1,2, Mishra D1, Mattoussi H1.
Bioconjugate chemistry.Bioconjug Chem.2016 Aug 23. [Epub ahead of print]
We detail the design of hydrophilic metal-coordinating ligands and their use for the effective coating of luminescent quantum dots (QDs). The ligand design exploits the specific, reagent-free nucleophilic addition reaction of amine-modified molecules toward maleic anhydride to introduce several lipo
PMID 27482756

Highly Efficient Catalytic Formation of (Z)-1,4-But-2-ene Diols using Water as a Nucleophile.

Guo W1, Martínez-Rodríguez L1, Martin E1, Escudero-Adán EC1, Kleij AW2,3.
Angewandte Chemie (International ed. in English).Angew Chem Int Ed Engl.2016 Aug 16. doi: 10.1002/anie.201603638. [Epub ahead of print]
The first general catalytic and highly stereoselective formation of (Z)-1,4-but-2-ene diols is described from readily available and modular vinyl-substituted cyclic carbonate precursors using water as a nucleophilic reagent. These 1,4-diol scaffolds can be generally prepared in high yields and with
PMID 27527353

岡本典子
YAKUGAKU ZASSHI 133(8), 879-887, 2013
… One-pot platinum(II)-catalyzed synthesis of indoles and isoquinolines has been achieved via isocyanates, which were derived from a Hofmann-type rearrangement of 2-alkynylbenzamides and 2-alkynylbenzylamides using a hypervalent iodine reagent. … As an extension of this approach, trans-2,3-dihydro-4-quinolones were synthesized via acid-catalyzed intermolecular [2+2]-cycloaddition of aldehydes and carbamates, which were formed from nucleophilic addition of alcohols to isocyanate intermediates. …
NAID 130003361976

山本英治
有機合成化学協会誌 70(9), 949-950, 2012-09-01
… Utilizing water as a reagent is one of the important topics in synthetic organic chemistry due to unique features of water for green chemistry. … Former one contains a mechanistically rare example that the enantioselection occurs in the nucleophilic attack of metal hydroxide species to electrophiles. …
NAID 10031076377

Improved Method for the Solid-Phase Synthesis of Oligoribonucleotide 5′-Triphosphates

Nagata Seigo,Takagaki Kazuchika,Wada Takeshi
Chemical and Pharmaceutical Bulletin 60(9), 1212-1215, 2012
… The method is based on the use of salicyl phosphorochloridite as the phosphitylating reagent and the improvement is characterized by the use of the highly reactive pyrophosphorylating reagent tris(tetra-n-butylammonium) hydrogen pyrophosphate instead of the conventional tri-n-butylammonium salt for the nucleophilic substitution reaction to form the cyclic ester intermediate. …
NAID 130001852536