核内受容体コアクチベーター1、核内レセプターコアクチベーター1
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/08/08 18:37:30」(JST)
Nuclear receptor coactivator 1 | |||||||||||||
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PDB rendering based on 1oj5. |
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Identifiers | |||||||||||||
Symbols | NCOA1 ; F-SRC-1; KAT13A; RIP160; SRC1; bHLHe42; bHLHe74 | ||||||||||||
External IDs | OMIM: 602691 MGI: 1276523 HomoloGene: 7859 ChEMBL: 1615387 GeneCards: NCOA1 Gene | ||||||||||||
EC number | 2.3.1.48 | ||||||||||||
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RNA expression pattern | |||||||||||||
More reference expression data | |||||||||||||
Orthologs | |||||||||||||
Species | Human | Mouse | |||||||||||
Entrez | 8648 | 17977 | |||||||||||
Ensembl | ENSG00000084676 | ENSMUSG00000020647 | |||||||||||
UniProt | Q15788 | P70365 | |||||||||||
RefSeq (mRNA) | NM_003743 | NM_010881 | |||||||||||
RefSeq (protein) | NP_003734 | NP_035011 | |||||||||||
Location (UCSC) | Chr 2: 24.71 – 24.99 Mb |
Chr 12: 4.25 – 4.48 Mb |
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PubMed search | [1] | [2] | |||||||||||
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The nuclear receptor coactivator 1 (NCOA1) is a transcriptional coregulatory protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity (EC 2.3.1.48). NCOA1 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA1, in turn, acylates histones, which makes downsteam DNA more accessible to transcription. Hence, NCOA1 assists nuclear receptors in the upregulation of DNA expression.[1][2]
NCOA1 is also frequently called steroid receptor coactivator-1 (SRC-1).
Nuclear receptor coactivator 1 possesses a basic helix-loop-helix (bHLH) domain and has been shown to interact with:
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リンク元 | 「核内受容体コアクチベーター1」「核内レセプターコアクチベーター1」 |
関連記事 | 「nuclear」「nuclear receptor」 |
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