細胞質および核内受容体
- 関
- cytoplasmic receptor、nuclear hormone receptor、nuclear receptor
WordNet
- of or relating to or constituting the nucleus of an atom; "nuclear physics"; "nuclear fission"; "nuclear forces"
- (weapons) deriving destructive energy from the release of atomic energy; "nuclear war"; "nuclear weapons"; "atomic bombs" (同)atomic
- constituting or like a nucleus; "annexation of the suburban fringe by the nuclear metropolis"; "the nuclear core of the congregation"
- of or relating to or constituting the nucleus of a cell; "nuclear membrane"; "nuclear division"
- of or relating to cytoplasm (同)cytoplasmatic
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
PrepTutorEJDIC
- 《語・句・節を対等に結んで》…『と』…,…や…,および / 《数詞を結合して》…『足す』…,…に加えて / …『しかも』…,…して,同時に… / 《時間的に》『そして』,それから,すると(and then) / 《当然の帰結として》…『ので』,…だから(and so) / 《おもに話》《命令文などの後で》『そうすれば』,そうしたら / 《追加・強調して》それに,しかも / 《対照的な内容を導いて》ところが,しかし(but) / 《譲歩的に》それなのに,それでいながら / 《A and Bで一体の関係を表して》《単数扱い》 / 《同一語を反復して多数・継続などを表して》 / 《同一の複数名詞を結合して変化・種類などを表して》 / 《話》《「形容詞+and+形容詞」の形で前の形容詞が後に副詞的に働く》 / 《話》《「動詞come, goなど+and+動詞」の形でandとその後の動詞が不定詞の働きをして》 / 《「動詞+and+動詞」の形で後の動詞が現在分詞の意を表して》 / 《話》《文頭において前の質問・意見などに同意を示して》そうとも,そして(Yes!and) / 《話》《文頭に置いて驚き・疑念・非難などを表して》ほんとうに;…なのに
- 『核の』,細胞核の / [『原子』]『核の』
- 細胞質の
- =sense organ / 受信装置
- (次にくる語の発音が母音で始まるときに用いる) / (子音[h]で始まり第1音節に強勢のない語の場合はanを用いることがある.ただし,この場合は[h]を発音しない)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/08/17 18:07:05」(JST)
[Wiki en表示]
Intracellular receptors are receptors located inside the cell rather than on its cell membrane. Classic hormones that use intracellular receptors include thyroid and steroid hormones. Examples are the class of nuclear receptors located in the cell nucleus and cytoplasm and the IP3 receptor located on the endoplasmic reticulum. The ligands that bind to them are usually intracellular second messengers like inositol trisphosphate (IP3) and extracellular lipophilic hormones like steroid hormones. Some intracrine peptide hormones also have intracellular receptors.
Examples
- other
- Sigma1 (neurosteroids)
- IP3 receptor (inositol triphosphate, IP3)
See also
External links
- Nuclear Receptor journal homepage
- Nuclear receptor resource at Georgetown University
- Nuclear receptor signalling atlas (NURSA, open-access journal)
Transcription factors and intracellular receptors
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(1) Basic domains
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(1.1) Basic leucine zipper (bZIP) |
- Activating transcription factor
- AP-1
- c-Fos
- FOSB
- FOSL1
- FOSL2
- JDP2
- c-Jun
- JUNB
- JunD
- BACH
- BATF
- BLZF1
- C/EBP
- CREB
- CREM
- DBP
- DDIT3
- GABPA
- HLF
- MAF
- NFE
- NFIL3
- NRL
- NRF
- XBP1
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(1.2) Basic helix-loop-helix (bHLH) |
- ATOH1
- AhR
- AHRR
- ARNT
- ASCL1
- BHLH
- ARNTL
- CLOCK
- EPAS1
- FIGLA
- HAND
- HES
- HEY
- HES1
- HIF
- ID
- LYL1
- MESP2
- MXD4
- MYCL1
- MYCN
- Myogenic regulatory factors
- Neurogenins
- NeuroD
- NPAS
- OLIG
- Pho4
- Scleraxis
- SIM
- TAL
- Twist
- USF1
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(1.3) bHLH-ZIP |
- AP-4
- MAX
- MITF
- MNT
- MLX
- MXI1
- Myc
- SREBP
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(1.4) NF-1 |
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(1.5) RF-X |
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(1.6) Basic helix-span-helix (bHSH) |
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(2) Zinc finger DNA-binding domains
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(2.1) Nuclear receptor (Cys4) |
subfamily 1 |
- Thyroid hormone
- CAR
- FXR
- LXR
- PPAR
- PXR
- RAR
- ROR
- Rev-ErbA
- VDR
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subfamily 2 |
- COUP-TF
- Ear-2
- HNF4
- PNR
- RXR
- Testicular receptor
- TLX
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subfamily 3 |
- Steroid hormone
- Androgen
- Estrogen
- Glucocorticoid
- Mineralocorticoid
- Progesterone
- Estrogen related
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subfamily 4 |
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subfamily 5 |
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subfamily 6 |
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subfamily 0 |
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(2.2) Other Cys4 |
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(2.3) Cys2His2 |
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(2.4) Cys6 |
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(2.5) Alternating composition |
- AIRE
- DIDO1
- GRLF1
- ING
- JARID
- JMJD1B
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(2.6) WRKY |
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(3) Helix-turn-helix domains
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(4) β-Scaffold factors with minor groove contacts
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(4.1) Rel homology region |
- NF-κB
- NFKB1
- NFKB2
- REL
- RELA
- RELB
- NFAT
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(4.2) STAT |
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(4.3) p53 |
- p53
- TBX
- 1
- 2
- 3
- 5
- 19
- 21
- 22
- TBR1
- TBR2
- TFT
- MYRF
- TP63
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(4.4) MADS box |
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(4.6) TATA-binding proteins |
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(4.7) High-mobility group |
- BBX
- HMGB
- HMGN
- HNF
- LEF1
- SOX
- 1
- 2
- 3
- 4
- 5
- 6
- 8
- 9
- 10
- 11
- 12
- 13
- 14
- 15
- 18
- 21
- SRY
- SSRP1
- TCF
- TOX
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(4.9) Grainyhead |
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(4.10) Cold-shock domain |
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(4.11) Runt |
- CBF
- CBFA2T2
- CBFA2T3
- RUNX1
- RUNX2
- RUNX3
- RUNX1T1
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(0) Other transcription factors
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(0.2) HMGI(Y) |
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(0.3) Pocket domain |
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(0.5) AP-2/EREBP-related factors |
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(0.6) Miscellaneous |
- ARID
- CAP
- IFI
- MLL
- MNDA
- NFY
- Rho/Sigma
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see also transcription factor/coregulator deficiencies
B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)
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Cell physiology: Cell signaling / Signal transduction
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Signaling pathways |
- GPCR
- RTK
- Notch
- JAK-STAT
- Akt/PKB
- Fas apoptosis
- Hippo
- PI3K/AKT/mTOR pathway
- Integrin receptors
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Agents |
Receptor ligands |
- Hormones
- Neurotransmitters/Neuropeptides/Neurohormones
- Cytokines
- Growth factors
- Signaling molecules
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Receptors |
- Cell surface
- Intracellular
- Co-receptor
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2nd messenger |
- cAMP-dependent pathway
- Ca2+ signaling
- Lipid signaling
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Assistants: |
- Signal transducing adaptor protein
- Scaffold protein
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Transcription factors |
- General
- Transcription preinitiation complex
- TFIID
- TFIIH
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By distance |
- Juxtacrine
- Autocrine / Paracrine
- Endocrine
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Other concepts |
- Intracrine action
- Synaptic transmission (Neurocrine signaling)
- Neuroendocrine signaling
- Exocrine signalling
- Mechanotransduction
- Phototransduction
- Ion channel gating
- Gap junction
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B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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UpToDate Contents
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English Journal
- p38 MAP Kinase Links CAR Activation and Inactivation in the Nucleus via Phosphorylation at Threonine 38.
- Hori T1, Moore R1, Negishi M2.
- Drug metabolism and disposition: the biological fate of chemicals.Drug Metab Dispos.2016 Jun;44(6):871-6. doi: 10.1124/dmd.116.070235. Epub 2016 Apr 13.
- Nuclear receptor constitutive androstane receptor (CAR, NR1I3), which regulates hepatic drug and energy metabolisms as well as cell growth and death, is sequestered in the cytoplasm as its inactive form phosphorylated at threonine 38. CAR activators elicit dephosphorylation, and nonphosphorylated CA
- PMID 27074912
- (68)Ga-DOTATATE PET in juvenile angiofibroma.
- Gronkiewicz Z1, Kukwa W1, Krolicki L2, Cyran-Chlebicka A3, Pawlak D4, Stankiewicz C5, Krzeski A1, Górnicka B3, Wolosz D3, Kunikowska J2.
- Future oncology (London, England).Future Oncol.2016 Jun;12(12):1483-91. doi: 10.2217/fon-2015-0074. Epub 2016 Mar 14.
- BACKGROUND: As somatostatin receptors (SSTRs) may be overexpressed in rapidly growing vessels, the aim of this study was the analysis of in vivo and in vitro SSTR2A expression in juvenile angiofibroma (JA).MATERIAL & METHODS: A group of six male adolescents with a diagnosis of primary, recurrent
- PMID 26971784
- Association between cytoplasmic CRABP2, altered retinoic acid signaling, and poor prognosis in glioblastoma.
- Liu RZ1, Li S1, Garcia E1, Glubrecht DD1, Yin Poon H1, Easaw JC2, Godbout R1.
- Glia.Glia.2016 Jun;64(6):963-76. doi: 10.1002/glia.22976. Epub 2016 Feb 19.
- Retinoic acid (RA), a metabolite of vitamin A, is required for the regulation of growth and development. Aberrant expression of molecules involved in RA signaling has been reported in various cancer types including glioblastoma multiforme (GBM). Cellular retinoic acid-binding protein 2 (CRABP2) has
- PMID 26893190
Japanese Journal
- Podocyte Injury Caused by Indoxyl Sulfate, a Uremic Toxin and Aryl-Hydrocarbon Receptor Ligand
- Ichii Osamu,Otsuka-Kanazawa Saori,Nakamura Teppei,Ueno Masaaki,Kon Yasuhiro,Chen Weiping,Rosenberg Avi Z.,Kopp Jeffrey B.
- PLOS one 9(9), e108448, 2014-09-22
- … Indoxyl sulfate is a uremic toxin and a ligand of the aryl-hydrocarbon receptor (AhR), a transcriptional regulator. … Elevated serum indoxyl sulfate levels may contribute to progressive kidney disease and associated vascular disease. … We asked whether indoxyl sulfate injures podocytes in vivo and in vitro. …
- NAID 120005525223
- Fisetin Inhibits Osteoclastogenesis Through Prevention of RANKL-Induced ROS Production by Nrf2-Mediated Up-regulation of Phase Ⅱ Antioxidant Enzymes
- Sakai Eiko,Shimada-Sugawara Megumi,Yamaguchi Yu [他],Sakamoto Hiroshi,Fumimoto Reiko,Fukuma Yutaka,Nishishita Kazuhisa,Okamoto Kuniaki,Tsukuba Takayuki
- Journal of Pharmacological Sciences 121(4), 288-298, 2013
- … Osteoclasts (OCLs) are multinucleated bone-resorbing cells that are differentiated by stimulation with receptor activator of nuclear factor kappa-B ligand (RANKL) and macrophage colony-stimulating factor. … Fisetin inhibited the formation of OCLs in a dose-dependent manner and suppressed the bone-resorbing activity of OCLs. …
- NAID 130003382582
- 6,4′-Dihydroxy-7-methoxyflavanone Inhibits Osteoclast Differentiation and Function
- Im Nam-Kyung,Choi Je-Yong,Oh Hyuncheol,Kim Youn-Chul,Jeong Gil-Saeng
- Biological and
- … It has been known that DMF has antioxidant, anti-inflammatory and neuroprotective effects. … In this study, we determined DMF's efficacy on osteoclasts differentiation and function using in vitro bone marrow macrophage osteoclast differentiation culture system. … DMF inhibited receptor activators of nuclear factor kappa-B ligand (RANKL) induced osteoclastogenesis dose dependently. …
- NAID 130003361434
★リンクテーブル★
[★]
核内受容体、核内レセプター、核レセプター
- 関
- cytoplasmic and nuclear receptor、cytoplasmic receptor、nuclear hormone receptor
[★]
- 関
- cytoplasmic and nuclear receptor、cytoplasmic receptor、nuclear receptor
[★]
- 関
- cytoplasmic and nuclear receptor、nuclear hormone receptor、nuclear receptor
[★]
- 英
- cytoplasmic and nuclear receptor
- 関
- 核内受容体、核内ホルモン受容体、細胞質受容体
[★]
- 関
- cytoplasm、cytoplasma、intracytoplasmic、protoplasm、protoplasmic
[★]
- 関
- cell nuclei、cell nucleus、nuclei、nucleo、nucleus
[★]
核内受容体、核内レセプター、核レセプター
- 関
- cytoplasmic and nuclear receptor、cytoplasmic receptor、nuclear hormone receptor