ノイラミン酸
WordNet
- street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
- any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
- having the characteristics of an acid; "an acid reaction"
PrepTutorEJDIC
- 酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/06/20 19:10:29」(JST)
[Wiki en表示]
Neuraminic acid |
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IUPAC name
(4S,5R,6R,7S,8R)-5-amino-4,6,7,8,9-
pentahydroxy-2-oxo-nonanoic acid
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Identifiers |
CAS number |
114-04-5 Y |
PubChem |
513472 |
ChemSpider |
447972 Y |
MeSH |
Neuraminic+Acids |
ChEBI |
CHEBI:49022 Y |
ChEMBL |
CHEMBL165084 N, CHEMBL1234621 |
Jmol-3D images |
Image 1 |
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O=C(O)[C@@]1(O)O[C@@H]([C@H](O)[C@H](O)CO)[C@H](N)[C@@H](O)C1
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InChI=1S/C9H17NO8/c10-5-3(12)1-9(17,8(15)16)18-7(5)6(14)4(13)2-11/h3-7,11-14,17H,1-2,10H2,(H,15,16)/t3-,4+,5+,6+,7+,9-/m0/s1 Y
Key: CERZMXAJYMMUDR-YOQZMRDMSA-N Y
InChI=1/C9H17NO8/c10-5-3(12)1-9(17,8(15)16)18-7(5)6(14)4(13)2-11/h3-7,11-14,17H,1-2,10H2,(H,15,16)/t3-,4+,5+,6+,7+,9-/m0/s1
Key: CERZMXAJYMMUDR-YOQZMRDMBH
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Properties |
Molecular formula |
C9H17NO8 |
Molar mass |
267.233 g/mol |
N (verify) (what is: Y/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
Infobox references |
Neuraminic acid (5-amino-3,5-dideoxy-D-glycero-D-galacto-non-2-ulosonic acid) is a 9-carbon monosaccharide, a derivative of a ketononose. Neuraminic acid may be visualized as the product of an aldol-condensation product of pyruvic acid and D-mannosamine (2-amino-2-deoxy-mannose). Neuraminic acid does not occur naturally, but many of its derivatives are found widely distributed in animal tissues and in bacteria, especially in glycoproteins and gangliosides. The N- or O-substituted derivatives of neuraminic acid are collectively known as sialic acids, the predominant form in mammalian cells being N-acetylneuraminic acid. The amino group bears either an acetyl or a glycolyl group. The hydroxyl substituents may vary considerably: acetyl, lactyl, methyl, sulfate and phosphate groups have been found.
The name "neuraminic acid" was introduced by German scientist E. Klenk in 1941, in reference to the brain lipids from which it was derived as a cleavage product.[1]
The symbol commonly used for neuraminic acid is Neu, and the residue is typically found with additional chemical modifications in biological systems. As a family, these residues are known as sialic acids. For example, N-acetyl-neuraminic acid, Neu5Ac, is typical in human glycoproteins.
Among their many biological functions, these structures are substrates for neuraminidase enzymes which cleave neuraminic acid residues. Human flu viruses have a neuraminidase enzyme, signified in the name "H#N#", where the H refers to an isoform of hemaglutinin and N refers to an isoform of viral neuraminidase.
See also[edit]
- N-acetylneuraminic acid
- Sialic acid
References[edit]
- ^ Klenk, E. 1941. Neuraminsäure, das Spaltprodukt eines neuen Gehirnlipoids. Zeitschr. f. Physiol. Chem. 1941; 268:50-58.
Types of carbohydrates
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General |
- Aldose
- Furanose
- Ketose
- Pyranose
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Geometry |
- Anomer
- Cyclohexane conformation
- Mutarotation
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Monosaccharides |
Dioses |
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Trioses |
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Tetroses |
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Pentoses |
- Aldopentose
- Arabinose
- Lyxose
- Ribose
- Xylose
- Deoxy sugar
- Ketopentose
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Hexoses |
- Aldohexose
- Allose
- Altrose
- Galactose
- Glucose
- Gulose
- Idose
- Mannose
- Talose
- Deoxy sugar
- Ketohexose
- Fructose
- Psicose
- Sorbose
- Tagatose
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Heptoses |
- Ketoheptose
- Mannoheptulose
- Sedoheptulose
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>7 |
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Multiple |
Disaccharides |
- Cellobiose
- Lactose
- Maltose
- Sucrose
- Trehalose
- Turanose
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Trisaccharides |
- Maltotriose
- Melezitose
- Raffinose
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Tetrasaccharides |
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Other
oligosaccharides |
- Acarbose
- Fructooligosaccharide (FOS)
- Galactooligosaccharide (GOS)
- Isomaltooligosaccharide (IMO)
- Maltodextrin
- Mannan-oligosaccharides (MOS)
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Polysaccharides |
- Beta-glucan
- Lentinan
- Sizofiran
- Zymosan
- Cellulose
- Chitin
- Dextrin / Dextran
- Fructose / Fructan
- Galactose / Galactan
- Glucose / Glucan
- Levan beta 2→6
- Mannan
- Starch
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- biochemical families: carbohydrates
- alcohols
- glycoproteins
- glycosides
- lipids
- eicosanoids
- fatty acids / intermediates
- phospholipids
- sphingolipids
- steroids
- nucleic acids
- constituents / intermediates
- proteins
- amino acids / intermediates
- tetrapyrroles / intermediates
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UpToDate Contents
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English Journal
- Quantification of sialic acids in red meat by UPLC-FLD using indoxylsialosides as internal standards.
- Yao HL1,2, Conway LP1, Wang MM1, Huang K1, Liu L3, Voglmeir J4.
- Glycoconjugate journal.Glycoconj J.2016 Apr;33(2):219-26. doi: 10.1007/s10719-016-9659-1. Epub 2016 Mar 11.
- Herein we describe a UPLC-FLD-based method for the quantification of the sialic acid content of red meat, using a synthetic neuraminic acid derivative as an internal standard. X-Gal-α-2,6-N-propionylneuraminic acid was synthesized via a chemoenzymatic pathway and its hydrolytic stability was charac
- PMID 26969460
- Isotype-specific glycosylation analysis of mouse immunoglobulin G by liquid chromatography-mass spectrometry.
- Maresch D1, Altmann F1.
- Proteomics.Proteomics.2016 Mar 9. doi: 10.1002/pmic.201500367. [Epub ahead of print]
- With mice being the top model organism in immunology and with Fc glycosylation being increasingly recognized as important modulator of antibody function, the time has come to take a look at the glycosylation of mouse immunoglobulin G isotypes. Tryptic glycopeptides of mouse IgG1, IgG2 and IgG3 diffe
- PMID 26960168
- Enzymatic synthesis of lactosylated and sialylated derivatives of epothilone A.
- Parajuli P1, Pandey RP1, Gurung RB1, Shin JY1, Jung HJ1, Kim DH2, Sohng JK3.
- Glycoconjugate journal.Glycoconj J.2016 Apr;33(2):137-46. doi: 10.1007/s10719-015-9646-y. Epub 2016 Feb 6.
- Epothilone A is a derivative of 16-membered polyketide natural product, which has comparable chemotherapeutic effect like taxol. Introduction of sialic acids to these chemotherapeutic agents could generate interesting therapeutic glycoconjugates with significant effects in clinical studies. Since, m
- PMID 26852037
Japanese Journal
- Co-expression of a heat shock transcription factor to improve conformational quality of recombinant protein in Escherichia coli(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)
- 3P039 Mycoplasma mobileの滑走時に"あし"として働くシアル酸レセプターの構造解析(01B.蛋白質:構造機能相関,ポスター,日本生物物理学会年会第51回(2013年度))
- Development of miracle medicines from sialic acids
Related Pictures
![Neuraminic acid](https://1mg.info/0/c/1/0964.jpg)
![File:Beta Neuraminic acid.svg - Wikipedia](https://1mg.info/0/c/1/0965.jpg)
![sialic acid or N-acetyl neuraminic acid](https://1mg.info/0/c/1/0967.jpg)
![200px-Neuraminic-acid-3D-balls.png](https://1mg.info/0/c/1/0968.jpg)
![Acetyl- neuraminic acid is a](https://1mg.info/0/c/1/0969.jpg)
★リンクテーブル★
[★]
- 英
- neuraminic acid
- 関
- シアル酸
- 炭素原子9個を含むアミノ糖
- 5-アミノ-3,5-ジデオキシ-D-グリセロ-D-ガラクト-ノヌルソン酸
[★]
- 関
- neuraminic acid
[★]
シチジン一リン酸N-アセチルノイラミン酸
- 関
- CMP-NANA
[★]
N-アセチルノイラミン酸