WordNet

street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
having the characteristics of an acid; "an acid reaction"

PrepTutorEJDIC

酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/06/20 19:10:29」(JST)

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Neuraminic acid (5-amino-3,5-dideoxy-D-glycero-D-galacto-non-2-ulosonic acid) is a 9-carbon monosaccharide, a derivative of a ketononose. Neuraminic acid may be visualized as the product of an aldol-condensation product of pyruvic acid and D-mannosamine (2-amino-2-deoxy-mannose). Neuraminic acid does not occur naturally, but many of its derivatives are found widely distributed in animal tissues and in bacteria, especially in glycoproteins and gangliosides. The N- or O-substituted derivatives of neuraminic acid are collectively known as sialic acids, the predominant form in mammalian cells being N-acetylneuraminic acid. The amino group bears either an acetyl or a glycolyl group. The hydroxyl substituents may vary considerably: acetyl, lactyl, methyl, sulfate and phosphate groups have been found.

The name "neuraminic acid" was introduced by German scientist E. Klenk in 1941, in reference to the brain lipids from which it was derived as a cleavage product.^[1]

The symbol commonly used for neuraminic acid is Neu, and the residue is typically found with additional chemical modifications in biological systems. As a family, these residues are known as sialic acids. For example, N-acetyl-neuraminic acid, Neu5Ac, is typical in human glycoproteins.

Among their many biological functions, these structures are substrates for neuraminidase enzymes which cleave neuraminic acid residues. Human flu viruses have a neuraminidase enzyme, signified in the name "H#N#", where the H refers to an isoform of hemaglutinin and N refers to an isoform of viral neuraminidase.

References[edit]

^ Klenk, E. 1941. Neuraminsäure, das Spaltprodukt eines neuen Gehirnlipoids. Zeitschr. f. Physiol. Chem. 1941; 268:50-58.

UpToDate Contents

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1. LSDおよび他の一般的な幻覚剤による中毒 intoxication from lsd and other common hallucinogens
2. 単純性および混合性酸塩基障害 simple and mixed acid base disorders
3. 成人における代謝性アシドーシスへのアプローチ approach to the adult with metabolic acidosis
4. 嚢胞性線維症：肝胆道系疾患 cystic fibrosis hepatobiliary disease
5. 尿酸のバランス uric acid balance

English Journal

Quantification of sialic acids in red meat by UPLC-FLD using indoxylsialosides as internal standards.

Yao HL1,2, Conway LP1, Wang MM1, Huang K1, Liu L3, Voglmeir J4.
Glycoconjugate journal.Glycoconj J.2016 Apr;33(2):219-26. doi: 10.1007/s10719-016-9659-1. Epub 2016 Mar 11.
Herein we describe a UPLC-FLD-based method for the quantification of the sialic acid content of red meat, using a synthetic neuraminic acid derivative as an internal standard. X-Gal-α-2,6-N-propionylneuraminic acid was synthesized via a chemoenzymatic pathway and its hydrolytic stability was charac
PMID 26969460

Isotype-specific glycosylation analysis of mouse immunoglobulin G by liquid chromatography-mass spectrometry.

Maresch D1, Altmann F1.
Proteomics.Proteomics.2016 Mar 9. doi: 10.1002/pmic.201500367. [Epub ahead of print]
With mice being the top model organism in immunology and with Fc glycosylation being increasingly recognized as important modulator of antibody function, the time has come to take a look at the glycosylation of mouse immunoglobulin G isotypes. Tryptic glycopeptides of mouse IgG1, IgG2 and IgG3 diffe
PMID 26960168

Enzymatic synthesis of lactosylated and sialylated derivatives of epothilone A.

Parajuli P1, Pandey RP1, Gurung RB1, Shin JY1, Jung HJ1, Kim DH2, Sohng JK3.
Glycoconjugate journal.Glycoconj J.2016 Apr;33(2):137-46. doi: 10.1007/s10719-015-9646-y. Epub 2016 Feb 6.
Epothilone A is a derivative of 16-membered polyketide natural product, which has comparable chemotherapeutic effect like taxol. Introduction of sialic acids to these chemotherapeutic agents could generate interesting therapeutic glycoconjugates with significant effects in clinical studies. Since, m
PMID 26852037

Japanese Journal

Co-expression of a heat shock transcription factor to improve conformational quality of recombinant protein in Escherichia coli(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)

Journal of bioscience and bioengineering 118(3), 242-248, 2014-09
NAID 110009857351

3P039 Mycoplasma mobileの滑走時に"あし"として働くシアル酸レセプターの構造解析(01B.蛋白質:構造機能相関,ポスター,日本生物物理学会年会第51回(2013年度))

生物物理 53(SUPPLEMENT_1-2), S218, 2013-09-13
NAID 110009819843

Development of miracle medicines from sialic acids

Proceedings of the Japan Academy, Series B 87(6), 328-361, 2011
NAID 130000903737

Related Pictures

★リンクテーブル★

リンク元	「ノイラミン酸」「neuraminate」
拡張検索	「cytidine monophosphate N-acetylneuraminic acid」「N-acetylneuraminic acid」

「ノイラミン酸」

Neuraminic acid
	IUPAC name (4S,5R,6R,7S,8R)-5-amino-4,6,7,8,9-; pentahydroxy-2-oxo-nonanoic acid
Identifiers
CAS number	114-04-5
PubChem	513472
ChemSpider	447972
MeSH	Neuraminic+Acids
ChEBI	CHEBI:49022
ChEMBL	CHEMBL165084 , CHEMBL1234621
Jmol-3D images	Image 1
	SMILES O=C(O)[C@@]1(O)O[C@@H]([C@H](O)[C@H](O)CO)[C@H](N)[C@@H](O)C1 ;
	InChI InChI=1S/C9H17NO8/c10-5-3(12)1-9(17,8(15)16)18-7(5)6(14)4(13)2-11/h3-7,11-14,17H,1-2,10H2,(H,15,16)/t3-,4+,5+,6+,7+,9-/m0/s1 ; Key: CERZMXAJYMMUDR-YOQZMRDMSA-N InChI=1/C9H17NO8/c10-5-3(12)1-9(17,8(15)16)18-7(5)6(14)4(13)2-11/h3-7,11-14,17H,1-2,10H2,(H,15,16)/t3-,4+,5+,6+,7+,9-/m0/s1; Key: CERZMXAJYMMUDR-YOQZMRDMBH ;
Properties
Molecular formula	C9H17NO8
Molar mass	267.233 g/mol
	(verify) (what is: /?); Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
	Infobox references

　　[★]

英: neuraminic acid
関: シアル酸

炭素原子9個を含むアミノ糖
5-アミノ-3,5-ジデオキシ-D-グリセロ-D-ガラクト-ノヌルソン酸

http://ja.wikipedia.org/wiki/%E3%83%8E%E3%82%A4%E3%83%A9%E3%83%9F%E3%83%B3%E9%85%B8
ノイラミン酸は、9炭素の単糖である。形式的には、ピルビン酸とD-マンノサミン（2-アミノ-2-デオキシマンノース）がアルドール縮合した構造を持つ。