関: neamine

WordNet

the 1st letter of the Roman alphabet (同)a
the blood group whose red cells carry the A antigen (同)type_A, group A
an antibiotic obtained from an actinomycete and used (as a sulphate under the trade name Neobiotic) as an intestinal antiseptic in surgery (同)fradicin, Neobiotic

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/11/21 20:37:02」(JST)

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Framycetin is an antibiotic of the aminoglycoside class similar to neomycin. Like neomycin, it has poor systemic absorption. It is used in topical preparations for infections of the skin, nose, ears, and eyes, often in combination with other antibacterial drugs and corticosteroids. It can also be used for gastrointestinal infections.

Framycetin is commonly sold as Soframycin and Sofra-Tulle. Also exists in veterinary products, as Framycetin sulf.

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English Journal

Novel aminoglycoside 2-phosphotransferase identified in a gram-negative pathogen.

Toth M, Frase H, Antunes NT, Vakulenko SB.SourceDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA.
Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2013 Jan;57(1):452-7. doi: 10.1128/AAC.02049-12. Epub 2012 Nov 5.
Aminoglycoside 2″-phosphotransferases are the major aminoglycoside-modifying enzymes in clinical isolates of enterococci and staphylococci. We describe a novel aminoglycoside 2″-phosphotransferase from the Gram-negative pathogen Campylobacter jejuni, which shares 78% amino acid sequence identity
PMID 23129050

Exploring the effect of aminoglycoside guanidinylation on ligands for Tau exon 10 splicing regulatory element RNA.

López-Senín P, Artigas G, Marchán V.SourceDepartament de Química Orgànica and IBUB, Universitat de Barcelona, Martí i Franquès 1-11, E-08028 Barcelona, Spain.
Organic & biomolecular chemistry.Org Biomol Chem.2012 Dec 14;10(46):9243-54. doi: 10.1039/c2ob26623g. Epub 2012 Oct 29.
We describe the effect of guanidinylation of the aminoglycoside moiety on acridine-neamine-containing ligands for the stem-loop structure located at the exon 10-5'-intron junction of Tau pre-mRNA, an important regulatory element of tau gene alternative splicing. On the basis of dynamic combinatorial
PMID 23108673

Cosubstrate tolerance of the aminoglycoside resistance enzyme Eis from Mycobacterium tuberculosis.

Chen W, Green KD, Garneau-Tsodikova S.SourceDepartment of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan, USA.
Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2012 Nov;56(11):5831-8. doi: 10.1128/AAC.00932-12. Epub 2012 Sep 4.
We previously demonstrated that aminoglycoside acetyltransferases (AACs) display expanded cosubstrate promiscuity. The enhanced intracellular survival (Eis) protein of Mycobacterium tuberculosis is responsible for the resistance of this pathogen to kanamycin A in a large fraction of clinical isolate
PMID 22948873

Japanese Journal

In vitro flowering and viable seed setting of transgenic lettuce cultures

G. Franklin,A. L. Oliveira,A. C. P. Dias
Plant Biotechnology advpub(0), 1101260016, 2011
… Six days old cotyledons were co-cultivated with Agrobacterium tumefaciens strain EHA105 harbouring the binary vector pCAMBIA2301 carrying the reporter gene α-glucuronidase intron (GUS-INT) and the marker gene neomycin phosphotransferase (NPTII). …
NAID 130000440903

Usefulness of a Non-invasive Reporter System for Monitoring Reprogramming State in Pig Cells : Results of a Cell Fusion Experiment

OZAWA Akio,AKASAKA Eri,WATANABE Satoshi,YOSHIDA Mitsutoshi,MIYOSHI Kazuchika,SATO Masahiro
The Journal of reproduction and development 56(4), 363-369, 2010-08-01
… 5.4-kb mouse Oct-3/4 promoter linked to the EGFP cDNA and neomycin expression unit and produced a porcine embryonic cell line stably incorporating it in the genome. …
NAID 10026621377

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リンク元	「ネオマイシンA」「neamine」
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「ネオマイシンA」

Framycetin
Systematic (IUPAC) name
	(2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl); -6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R); -4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl); -4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy; -5-(hydroxymethyl)oxolan-2-yl]oxy; -3-hydroxycyclohexyl]oxyoxane-3,4-diol
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy cat.	?
Legal status	?
Routes	oral, topical
Identifiers
CAS number	119-04-0
ATC code	R01AX08 S01AA07 D09AA01 (dressing) QJ01GB91
PubChem	CID 8378
DrugBank	DB00452
ChemSpider	8075
UNII	4BOC774388
KEGG	D05140
ChEBI	CHEBI:7508
ChEMBL	CHEMBL184618
Chemical data
Formula	C23H46N6O13
Mol. mass	614.644 g/mol
	SMILES O([C@H]3[C@H](O[C@@H]2O[C@H](CO)[C@@H](O[C@H]1O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]1N)[C@H]2O)[C@@H](O)[C@H](N)C[C@@H]3N)[C@H]4O[C@@H]([C@@H](O)[C@H](O)[C@H]4N)CN;
	InChI InChI=1S/C23H46N6O13/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22/h5-23,30-36H,1-4,24-29H2/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1 ; Key:PGBHMTALBVVCIT-VCIWKGPPSA-N ;
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