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Naftopidil (INN, marketed under the brand name Flivas) is an antihypertensive drug which acts as a selective α₁-adrenergic receptor antagonist or alpha blocker.^[1]

References

^ Sakai H, Igawa T, Onita T, Furukawa M, Hakariya T, Hayashi M, Matsuya F, Shida Y, Nishimura N, Yogi Y, Tsurusaki T, Takehara K, Nomata K, Shiraishi K, Shono T, Aoki D, Kanetake H. (2011). "Efficacy of naftopidil in patients with overactive bladder associated with benign prostatic hyperplasia: prospective randomized controlled study to compare differences in efficacy between morning and evening medication". Hinyokika Kiyo. 57 (1): 7–13. PMID 21304253.

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1. 前立腺肥大症の内科的治療 medical treatment of benign prostatic hyperplasia
2. 成人における白内障 cataract in adults

English Journal

Novel naftopidil-related derivatives and their biological effects as alpha1-adrenoceptors antagonists and antiproliferative agents.

Huang J1, He F2, Huang M1, Liu X1, Xiong Y3, Huang Y1, Zhu L1, Yang Y4, Xu X1, Yuan M5.
European journal of medicinal chemistry.Eur J Med Chem.2015 May 26;96:83-91. doi: 10.1016/j.ejmech.2015.04.005. Epub 2015 Apr 7.
Eleven novel naftopidil-related compounds that contain amide and indole groups were designed and synthesized. The biological effects of these compounds on three α1-adrenoceptor subtypes and cancerous human prostate cell lines (PC-3, DU-145, and LNCaP) were determined. Compounds 2, 3, 5, 11, and 12
PMID 25874333

Adrenergic antagonists restrict replication of Legionella.

Harrison CF1, Kicka S2, Kranjc A3, Finsel I4, Chiriano G3, Ouertatani-Sakouhi H5, Soldati T2, Scapozza L3, Hilbi H6.
Microbiology (Reading, England).Microbiology.2015 Apr 14. pii: mic.0.000094. doi: 10.1099/mic.0.000094. [Epub ahead of print]
Legionella pneumophila is a facultative intracellular bacterium, which upon inhalation can cause a potentially fatal pneumonia termed Legionnaires´ disease. The opportunistic pathogen grows in environmental amoebae and mammalian macrophages within a unique membrane-bound compartment, the 'Legionell
PMID 25873585

Naftopidil versus flopropione as medical expulsive therapy for distal ureteral stones: results of a randomized, multicenter, double-blind, controlled trial.

Kohjimoto Y1, Hagino K, Ogawa T, Inagaki T, Kitamura S, Nishihata M, Iba A, Matsumura N, Hara I.
World journal of urology.World J Urol.2015 Apr 14. [Epub ahead of print]
PURPOSE: A multicenter, double-blind, randomized, controlled trial was conducted to determine the efficacy of naftopidil as medical expulsive therapy (MET) for patients with distal ureteral stones.METHODS: Ninety-two patients presenting with a single distal ureteral stone ≤10 mm were randomly ass
PMID 25869815

Japanese Journal

過活動膀胱を伴う前立腺肥大症患者に対するナフトピジルの臨床的効果

宮島次郎,松岡啓,川越伸俊,古賀紀子,井手篤史,西原聖顕,斎藤孝二郎,桃園幸介,江島和久,中川剛,陶山俊輔,宮原司,大西怜,築井克聡,江口善朗,名切信,中並正之,境優一,境大介,中川克之,山下拓郎,古賀弘,三原典
西日本泌尿器科 74(1), 8-15, 2012-01-20
NAID 10030440454

困窮度の改善から見たBPH/male LUTS症例に対するナフトピジルの有効性に関する検討

池本庸,成岡健人,梅津清和 [他]
臨床泌尿器科 65(5), 315-321, 2011-04
NAID 40018806523

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★リンクテーブル★

リンク元

「ナフトピジル」

Naftopidil
Systematic (IUPAC) name
	1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-(1-naphthyloxy)propan-2-ol
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	℞ Prescription only;
Routes	Oral
Identifiers
CAS number	57149-07-2
ATC code	None
PubChem	CID 4418
ChemSpider	4265
UNII	R9PHW59SFN
Chemical data
Formula	C24H28N2O3
Molecular mass	392.49 g/mol
	SMILES COC1=CC=CC=C1N2CCN(CC2)CC(COC3=CC=CC4=CC=CC=C43)O;
	InChI InChI=1S/C24H28N2O3/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23/h2-12,20,27H,13-18H2,1H3 ; Key:HRRBJVNMSRJFHQ-UHFFFAOYSA-N ;
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　　[★]

英: naftopidil
商: アビショット、フリバス
関: 前立腺肥大症、その他の泌尿生殖器官及び肛門用薬

α1受容体阻害薬
血管のα1受容体よりむしろ前立腺や尿道のα1受容体を阻害する。

[1] Sakai H, Igawa T, Onita T, Furukawa M, Hakariya T, Hayashi M, Matsuya F, Shida Y, Nishimura N, Yogi Y, Tsurusaki T, Takehara K, Nomata K, Shiraishi K, Shono T, Aoki D, Kanetake H. (2011). "Efficacy of naftopidil in patients with overactive bladder associated with benign prostatic hyperplasia: prospective randomized controlled study to compare differences in efficacy between morning and evening medication". Hinyokika Kiyo. 57 (1): 7–13. PMID 21304253.

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naftopidil