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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/09/12 00:08:45」(JST)
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English Journal
- Relationship Between the Severity of Acne Vulgaris and Antimicrobial Resistance of Bacteria Isolated from Acne Lesions in a Hospital of Japan.
- Nakase K1, Nakaminami H, Takenaka Y, Hayashi N, Kawashima M, Noguchi N.Author information 1Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432;AbstractPropionibacterium acnes and Staphylococcus epidermidis are normal skin inhabitants that are frequently isolated from lesions caused by acne, and these microorganisms are considered to contribute to the inflammation of acne. In the present study, we examined the antimicrobial susceptibilities and resistance mechanisms of P. acnes and S. epidermidis that were isolated from patients with acne vulgaris in a university hospital in Japan from 2009 to 2010. Additionally, we analysed the relationship between the antimicrobial resistance of P. acnes and the severity of acne vulgaris. Some P. acnes strains (18.8% (13/69)) were resistant to clindamycin. All strains had a mutation in the 23S rRNA gene, except for one strain that expressed erm(X) which encoded a 23S rRNA methylase. Tetracycline-resistant P. acnes were found in 4.3% (3/69) of the strains, and those resistances were caused by a mutation in the 16S rRNA gene. Furthermore, three strains with reduced susceptibility to nadifloxacin (MIC = 16 µg ml-1) were detected. When analysing the correlation between the antimicrobial resistance of P. acnes and S. epidermidis, more than 80% of the patients who carried clindamycin-resistant P. acnes also carried clindamycin-resistant S. epidermidis. However, no epidemic strain that exhibited antimicrobial resistance was detected in the P. acnes strains when analysed by pulsed-field gel electrophoresis. Therefore, our results suggest that the antimicrobial resistance of P. acne is closely related to antimicrobial therapy. Additionally, those P. acnes strains tended to be frequently found in severe acne patients rather than in mild acne patients. Consequently, the data support a relationship between using antimicrobial agents and the emergence of antimicrobial resistance.
- Journal of medical microbiology.J Med Microbiol.2014 Feb 12. doi: 10.1099/jmm.0.067611-0. [Epub ahead of print]
- Propionibacterium acnes and Staphylococcus epidermidis are normal skin inhabitants that are frequently isolated from lesions caused by acne, and these microorganisms are considered to contribute to the inflammation of acne. In the present study, we examined the antimicrobial susceptibilities and res
- PMID 24523159
- Cetuximab-induced skin exanthema: prophylactic and reactive skin therapy are equally effective.
- Wehler TC1, Graf C, Möhler M, Herzog J, Berger MR, Gockel I, Lang H, Theobald M, Galle PR, Schimanski CC.Author information 1Third Department of Internal Medicine, Johannes Gutenberg University of Mainz, Mainz, Germany, thomas.wehler@unimedizin-mainz.de.Erratum inJ Cancer Res Clin Oncol. 2013 Nov;139(11):1961-2. AbstractPURPOSE: Treatment with cetuximab is accompanied by the development of an acneiform follicular skin exanthema in more than 80 % of patients. Severe exanthema (grade III/IV) develops in about 9-19 % of patients with the necessity of cetuximab dose reduction or cessation.
- Journal of cancer research and clinical oncology.J Cancer Res Clin Oncol.2013 Oct;139(10):1667-72. doi: 10.1007/s00432-013-1483-4. Epub 2013 Aug 7.
- PURPOSE: Treatment with cetuximab is accompanied by the development of an acneiform follicular skin exanthema in more than 80 % of patients. Severe exanthema (grade III/IV) develops in about 9-19 % of patients with the necessity of cetuximab dose reduction or cessation.METHODS: The study presented w
- PMID 23918349
- Clinical and bacteriological evaluation of adapalene 0.1% gel plus nadifloxacin 1% cream versus adapalene 0.1% gel in patients with acne vulgaris.
- Takigawa M1, Tokura Y, Shimada S, Furukawa F, Noguchi N, Ito T; Acne Study Group.Author information 1Hamamatsu University School of Medicine, Tokyo, Japan. toriimd@shahochu.jpAbstractThis multicenter, randomized parallel group study investigated the efficacy and tolerability of adapalene 0.1% gel plus nadifloxacin 1% cream (combination therapy) compared with adapalene gel (monotherapy) during 12-week treatment of acne vulgaris. A total of 184 Japanese patients aged above 12 years with moderate to severe acne as indicated by the Japanese severity grading criteria were randomized to combination therapy (n = 84) and monotherapy (n = 100) groups, both having comparable demographic and baseline characteristics. Adapalene was applied only to inflammatory acne lesions in order to minimize skin irritation and ensure the treatment results. Efficacy and safety evaluations, treatment compliance and satisfaction with drug application were periodically monitored. The combination therapy provided a significantly greater efficacy than adapalene in decrement of inflammatory papulopustular lesions at 4 weeks and thereafter (P = 0.0056). The overall judgment of the therapeutic efficacy by the physician at the end of study revealed a significant difference (P = 0.02496) between the groups in favor of combination therapy. Dryness was reported in a greater proportion of patients undergoing monotherapy than combination therapy at weeks 2 and 4 (P = 0.04652). The patient self-assessment in satisfaction with the drug application at the end of study revealed a significant difference (P = 0.00268) between the groups in favor of combination therapy. Among 76 strains of Propionibacterium acnes isolated from 87 patients, no strain was resistant to nadifloxacin. Thus, the simultaneous use of adapalene and nadifloxacin may provide an additive and complementary effect, resulting in clinical superiority and greater patient adherence compared to adapalene monotherapy.
- The Journal of dermatology.J Dermatol.2013 Aug;40(8):620-5. doi: 10.1111/1346-8138.12189. Epub 2013 Jun 3.
- This multicenter, randomized parallel group study investigated the efficacy and tolerability of adapalene 0.1% gel plus nadifloxacin 1% cream (combination therapy) compared with adapalene gel (monotherapy) during 12-week treatment of acne vulgaris. A total of 184 Japanese patients aged above 12 yea
- PMID 23724808
Japanese Journal
- 症例 ナジフロキサシンクリーム外用後に発症した接触皮膚炎症候群
- 岸本 和裕,福田 豊,高橋 亮一
- 皮膚科の臨床 52(13), 2009-2012, 2010-12
- NAID 40017424384
- アダパレンゲル(ディフェリンゲル)の配合変化
- 大谷 道輝,山岡 由紗,松元 美香,並木 路広,山村 喜一,江藤 隆史
- 薬剤学 = The archives of practical pharmacy 69(6), 470-476, 2009-11-01
- NAID 10025720959
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