WordNet
- a measure of the money supply; M2 plus deposits at institutions that are not banks (such as savings and loan associations)
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
- the 13th letter of the Roman alphabet (同)m
- the imperial dynasty of China from 1368 to 1644 (同)Ming dynasty
PrepTutorEJDIC
- =sense organ / 受信装置
- Mach number / mark[s] / Monsieur
- (中国の)明,明朝(1368‐1644)
UpToDate Contents
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- 1. 慢性閉塞性肺疾患（COPD）における抗コリン療法の役割 role of anticholinergic therapy in copd
- 2. 神経筋接合部に作用する毒素の概要 overview of neuromuscular junction toxins
- 3. 抗コリン剤中毒 anticholinergic poisoning
- 4. 重症筋無力症の病因 pathogenesis of myasthenia gravis
- 5. 尿失禁の疫学、危険因子、および病因 epidemiology risk factors and pathogenesis of urinary incontinence
English Journal
- Modulation of A-type K(+) channels by the short-chain cobrotoxin through the protein kinase C-delta isoform decreases membrane excitability in dorsal root ganglion neurons.
- Guo Q, Jiang YJ, Jin H, Jiang XH, Gu B, Zhang YM, Wang JG, Qin ZH, Tao J.SourceDepartment of Emergency and Intensive Care Unit & Institute of Neuroscience, The First Affiliated Hospital of Soochow University, Suzhou 215006, P.R. China; Department of Neurobiology, Key Laboratory of Pain Research and Therapy, Medical College of Soochow University, Suzhou 215123, P.R. China.
- Biochemical pharmacology.Biochem Pharmacol.2013 May 1;85(9):1352-62. doi: 10.1016/j.bcp.2013.02.019. Epub 2013 Feb 19.
- A-type K(+) channels are crucial in controlling neuronal excitability, and their regulation in sensory neurons may alter pain sensation. In this study, we identified the functional role of cobrotoxin, the short-chain α-neurotoxin isolated from Naja atra venom, which acts in the regulation of the tr
- PMID 23435353
- Disruption of cerebellar cholinergic system in hypoxic neonatal rats and its regulation with glucose, oxygen and epinephrine resuscitations.
- Anju TR, Ajayan MS, Paulose CS.SourceMolecular Neurobiology and Cell Biology Unit, Centre for Neuroscience, Department of Biotechnology, Cochin University of Science and Technology, Cochin 682022, Kerala, India.
- Neuroscience.Neuroscience.2013 Apr 16;236:253-61. doi: 10.1016/j.neuroscience.2012.12.056. Epub 2013 Jan 30.
- Cholinergic system is important for respiratory control from the first days of life. Disturbances in cholinergic pathway due to early life stress like hypoxic shock can adversely affect the ventilatory response. The present study evaluates neonatal hypoxic insult mediated cholinergic disturbances an
- PMID 23376739
- The Muscarinic M3 Acetylcholine receptor exists as two differently sized complexes at the plasma membrane.
- Patowary S, Alvarez-Curto E, Xu TR, Holz JD, Oliver JA, Milligan G, Raicu V.AbstractThe literature on G protein-coupled receptor (GPCR) homo-oligomerization encompasses conflicting views that range from interpretations that GPCRs must be monomeric, through comparatively newer proposals that they exist as dimers or higher-order oligomers, to suggestions that such quaternary structures are rather ephemeral or merely accidental and may serve no functional purpose. Here we use a novel method of Förster Resonance Energy Transfer (FRET) spectrometry and controlled expression of energy donor-tagged species to show that muscarinic M3 acetylcholine receptors (M3R) at the plasma membrane exist as stable dimeric complexes, a large fraction of which interact dynamically to form tetramers without the presence of trimers, pentamers, hexamers, etc. That M3R dimeric units interact dynamically was also supported by co-immunoprecipitation of receptors synthesized at distinct times. Based on all these findings, we propose a conceptual framework that may reconcile the conflicting views on the quaternary structure of GPCRs.
- The Biochemical journal.Biochem J.2013 Mar 25. [Epub ahead of print]
- The literature on G protein-coupled receptor (GPCR) homo-oligomerization encompasses conflicting views that range from interpretations that GPCRs must be monomeric, through comparatively newer proposals that they exist as dimers or higher-order oligomers, to suggestions that such quaternary structur
- PMID 23521066
Japanese Journal
- Muscarinic Receptor Binding of the Novel Radioligand, [³H]Imidafenacin in the Human Bladder and Parotid Gland
- Yoshida Akira,Kuraoka Shiori,Ito Yoshihiko [他],Okura Takashi,Deguchi Yoshiharu,Otsuka Atsushi,Ozono Seiichiro,Takeda Masayuki,Masuyama Keisuke,Araki Isao,Yamada Shizuo
- Journal of Pharmacological Sciences 124(1), 40-46, 2014
- … The aim of the current study was to demonstrate highly specific and direct binding activity of tritium ([3H])-labeled imidafenacin for labeling muscarinic receptors in human bladder and parotid gland. … The Ki for imidafenacin in the human bladder approximately corresponded to pharmacological potency for the competitive blockade of carbachol-induced contractions of bladder, indicating a close correlation between binding affinity of imidafenacin to bladder muscarinic receptors and its pharmacological effects in the bladder. …
- NAID 130003382631
- シェーグレン症候群における抗M3R抗体の解析
- 坪井 洋人,浅島 弘充,住田 孝之
- 最新医学 68(9), 1958-1965, 2013-09
- NAID 40019799803
- Investigation of Antimuscarinic Receptor Autoantibodies in Patients with Acquired Idiopathic Generalized Anhidrosis
- Asahina Masato,Sano Kenji,Fujinuma Yoshikatsu,Kuwabara Satoshi
- Internal Medicine 52(24), 2733-2737, 2013
- … Objective The autoimmune mechanism is considered to play an important role in the development of acquired idiopathic generalized anhidrosis (AIGA), and muscarinic M3 receptors (M3Rs) on eccrine glands are possible autoimmune targets. … We investigated the existence of autoantibodies against M3Rs in AIGA patients. …
- NAID 130003383752
Related Links
- 1. Nature. 2012 Feb 22;482(7386):552-6. doi: 10.1038/nature10867. Structure and dynamics of the M3 muscarinic acetylcholine receptor. Kruse AC(1), Hu J, Pan AC, Arlow DH, Rosenbaum DM, Rosemond E, Green HF ...
- Muscarinic acetylcholine receptors are members of rhodopsin-like G-protein coupled receptor family. They play several important roles; they mediate many of the effects of acetylcholine in the central and peripheral nervous system ...
Related Pictures
★リンクテーブル★
| リンク元 | 「ムスカリンM3受容体」「ムスカリンM3レセプター」 |
| 関連記事 | 「M3」「muscarinic」「M」「M3 receptor」 |
「ムスカリンM3受容体」
「ムスカリンM3レセプター」
「M3」
- 急性前骨髄球性白血病 acute promyelocytic leukemia APL
- ムスカリン受容体のうち分泌を制御する受容体の一型
- グラスゴー・コーマ・スケール best motor response(M)の下から3番目の評価。四肢の異常屈曲(abnormal flexion)で除皮質硬直に相当。
「muscarinic」
- adj.
- ムスカリン性の、ムスカリンの
- n.
- 関
- cholinergic、cholinergic agent、cholinergic drug、cholinomimetic、muscarine、muscarinic agent、muscarinic agonist