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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/12/16 21:04:34」(JST)

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Aztreonam. (The four-membered ring at the bottom is the β-lactam. There is a second thiazole ring, but it is not fused to the β-lactam ring.)

Tigemonam

Monobactams are β-lactam compounds wherein the β-lactam ring is alone and not fused to another ring, in contrast to most other β-lactams. They are effective only against aerobic Gram-negative bacteria (e.g., Neisseria, Pseudomonas).

Currently the only commercially available monobactam antibiotic is aztreonam.

Other examples of monobactams are tigemonam,^[1] nocardicin A, and tabtoxin.

Adverse effects to monobactams can include skin rash and occasional abnormal liver functions.

They have no cross-hypersensitivity reactions with penicillin but like penicillins can trigger seizures in patients with history of seizures.

References

^ Fuchs PC, Jones RN, Barry AL (March 1988). "In vitro antimicrobial activity of tigemonam, a new orally administered monobactam". Antimicrob. Agents Chemother. 32 (3): 346–9. doi:10.1128/aac.32.3.346. PMC 172173. PMID 3259122.

External links

Monobactams at the US National Library of Medicine Medical Subject Headings (MeSH)

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UpToDate Contents

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1. β-ラクタマーゼ阻害剤、カルバペネム系、およびモノバクタム系抗菌薬の併用 combination beta lactamase inhibitors carbapenems and monobactams
2. β-ラクタム系抗生物質：作用機序、耐性および有害作用 beta lactam antibiotics mechanisms of action and resistance and adverse effects
3. 基質特異性拡張型β-ラクタマーゼ extended spectrum beta lactamases
4. Penicillin allergy: Immediate reactions
5. セファロスポリン-アレルギー患者：セファロスポリンおよび関連抗菌薬のその後の使用 cephalosporin allergic patients subsequent use of cephalosporins and related antibiotics

English Journal

Novel monobactams utilizing a siderophore uptake mechanism for the treatment of gram-negative infections.

Mitton-Fry MJ, Arcari JT, Brown MF, Casavant JM, Finegan SM, Flanagan ME, Gao H, George DM, Gerstenberger BS, Han S, Hardink JR, Harris TM, Hoang T, Huband MD, Irvine R, Lall MS, Megan Lemmon M, Li C, Lin J, McCurdy SP, Mueller JP, Mullins L, Niosi M, Noe MC, Pattavina D, Penzien J, Plummer MS, Risley H, Schuff BP, Shanmugasundaram V, Starr JT, Sun J, Winton J, Young JA.SourceMedicinal Chemistry, Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, USA.
Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2012 Sep 15;22(18):5989-94. doi: 10.1016/j.bmcl.2012.07.005. Epub 2012 Jul 20.
Novel siderophore-linked monobactams with in vitro and in vivo anti-microbial activity against MDR Gram-negative pathogens are described.Copyright © 2012. Published by Elsevier Ltd.
PMID 22892121

KPC-mediated resistance in Klebsiella pneumoniae in two hospitals in Padua, Italy, June 2009-December 2011: massive spreading of a KPC-3-encoding plasmid and involvement of non-intensive care units.

Richter SN, Frasson I, Franchin E, Bergo C, Lavezzo E, Barzon L, Cavallaro A, Palù G.SourceDepartment of Molecular Medicine, University of Padua, Via Gabelli, 63, 35121, Padua, Italy. sara.richter@unipd.it.
Gut pathogens.Gut Pathog.2012 Jul 16;4(1):7. doi: 10.1186/1757-4749-4-7.
BACKGROUND: Klebsiella pneumoniae carbapenemases (KPCs) producing bacteria have emerged as a cause of multidrug-resistant nosocomial infections worldwide. KPCs are plasmid-encoded enzymes capable of hydrolysing a broad spectrum of beta-lactams, including carbapenems and monobactams, therefore worryi
PMID 22800501