monobactam

モノバクタム。モノバクタム系抗菌薬

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2019/07/09 21:21:41」(JST)

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Aztreonam. (The four-membered ring at the bottom is the β-lactam. There is a second thiazole ring, but it is not fused to the β-lactam ring.)

Tigemonam

Monobactams are monocyclic and bacterially-produced β-lactam antibiotics. The β-lactam ring is not fused to another ring, in contrast to most other β-lactams. Monobactams are effective only against aerobic Gram-negative bacteria (e.g., Neisseria, Pseudomonas). Siderophore-conjugated monobactams show promise for the treatment of multi drug-resistant pathogens.

Aztreonam is a commercially available monobactam antibiotic. Other examples of monobactams are tigemonam, nocardicin A, and tabtoxin.

Adverse effects to monobactams can include skin rash and occasional abnormal liver functions.

They have no cross-hypersensitivity reactions with penicillin but like penicillins can trigger seizures in patients with history of seizures.

External links

• Monobactams at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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• 1. β-ラクタマーゼ阻害剤、カルバペネム系、およびモノバクタム系抗菌薬の併用 combination beta lactamase inhibitors carbapenems and monobactams
• 2. ペニシリン-アレルギー患者：セフェム系、カルバペネム系、およびモノバクタム系の使用 penicillin allergic patients use of cephalosporins carbapenems and monobactams
• 3. セファロスポリン-アレルギー患者：セファロスポリンおよび関連抗菌薬のその後の使用 cephalosporin allergic patients subsequent use of cephalosporins and related antibiotics
• 4. 基質特異性拡張型β-ラクタマーゼ extended spectrum beta lactamases
• 5. β-ラクタム系抗生物質：作用機序、耐性および有害作用 beta lactam antibiotics mechanisms of action and resistance and adverse effects

English Journal

• Expanded Substrate Activity of OXA-24/40 in Carbapenem-Resistant Acinetobacter baumannii Involves Enhanced Binding Loop Flexibility.

• Staude MW1, Leonard DA2, Peng JW1.
• Biochemistry.Biochemistry.2016 Nov 29;55(47):6535-6544. Epub 2016 Nov 11.
• Gram-negative bacteria resist β-lactam antibiotics primarily by deploying β-lactamase proteins that hydrolytically destroy the antibiotics. In clinical settings, these bacteria are producing variant β-lactamases with "gain-of-activity" mutations that inactivate a broader range of β-lactams. Lear
• PMID 27783477

• Deciphering the Resistome of the Widespread Pseudomonas aeruginosa Sequence Type 175 International High-Risk Clone through Whole-Genome Sequencing.

• Cabot G1, López-Causapé C1, Ocampo-Sosa AA2, Sommer LM3, Domínguez MÁ4, Zamorano L1, Juan C1, Tubau F4, Rodríguez C2, Moyà B1, Peña C5, Martínez-Martínez L2,6, Plesiat P7, Oliver A8.
• Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2016 Nov 21;60(12):7415-7423. Print 2016 Dec.
• Whole-genome sequencing (WGS) was used for the characterization of the frequently extensively drug resistant (XDR) Pseudomonas aeruginosa sequence type 175 (ST175) high-risk clone. A total of 18 ST175 isolates recovered from 8 different Spanish hospitals were analyzed; 4 isolates from 4 different Fr
• PMID 27736752

• Return to sender: the need to re-address patient antibiotic allergy labels in Australia and New Zealand.

• Trubiano JA1,2,3, Worth LJ4,5, Urbancic K6,7, Brown TM8, Paterson DL8; Australasian Society for Infectious Diseases Clinical Research Network, Lucas M9; Australasian Society of Clinical Immunology and Allergy, Phillips E10,11.
• Internal medicine journal.Intern Med J.2016 Nov;46(11):1311-1317. doi: 10.1111/imj.13221.
• BACKGROUND/AIM: Antibiotic allergies are frequently reported and have significant impacts upon appropriate prescribing and clinical outcomes. We surveyed infectious diseases physicians, allergists, clinical immunologists and hospital pharmacists to evaluate antibiotic allergy knowledge and service d
• PMID 27527526

Japanese Journal

• Effect of conalbumin on the activity of Syn 2190, a 1,5 dihydroxy-4-pyridon monobactam inhibitor of AmpC beta-lactamases

• BABINI GS
• Journal of Antimicrobial Chemotherapy 45, 105-109, 2000
• NAID 30018438894

• エノレート化学を基盤とする新しい不斉合成法の開発 : β-ラクタム合成と不斉記憶

• 川端 猛夫
• 藥學雜誌 115(9), 700-715, 1995-09-25
• … The product 11 was transformed to an intermediate for the synthesis of monobactam antibiotic carmonam. … Chemoselective epimerization of cis-β-lactam 13 was accomplished with trifluoroacetic acid, and the resulting trans-isomer 14 was converted into an intermediate of monobactam antibiotic aztreonam. …
• NAID 110003648984

• Synthesis of Novel Monobactams Bearing an (R)-1-Hydroxyethyl Group and an (S)-1-Carbamoyl-oxyethyl Group at the C_<3,4>-Positions

• 小尾 紀行,伊藤 芳雄,寺島 孜郎
• Chemical & pharmaceutical bulletin 38(4), 917-924, 1990-04-25
• Various structural types of monobactams bearing an (R)-1-hydroxyethyl and an (S)-1-carbamoyloxyethyl group at the C_<3,4>-positions, respectively, could be synthesized from (3S, 4S)-4-[(S)-1-ben …
• NAID 110003628454

Related Links

• monobactam - Medical Dictionary

mon·o·bac·tam (mon'ō-bak'tam), A class of antibiotic that has a monocyclic β-lactam nucleus and is structurally different from other β-lactams; for example, aztreonam. monobactam /mon·o·bac·tam/ (-bak´tam) 1. a class of synthetic ...

• Monobactamsとは - goo Wikipedia (ウィキペディア)

The only commercially available monobactam antibiotic is aztreonam. Other examples of monobactams are tigemonam, [1] nocardicin A, and tabtoxin. References ^ Fuchs PC, Jones RN, Barry AL (March 1988). "In vitro. Agents ...

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