WordNet

the secretion of an endocrine gland that is transmitted by the blood to the tissue on which it has a specific effect (同)endocrine, internal_secretion

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ホルモン

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/19 08:12:10」(JST)

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Ecdysone is a steroidal prohormone of the major insect molting hormone 20-hydroxyecdysone, which is secreted from the prothoracic glands. Insect molting hormones (ecdysone and its homologues) are generally called ecdysteroids. Ecdysteroids act as moulting hormones of arthropods but also occur in other related phyla where they can play different roles. In Drosophila melanogaster, an increase in ecdysone concentration induces the expression of genes coding for proteins that the larva requires, and it causes chromosome puffs (sites of high expression) to form in polytene chromosomes. Ecdysteroids also appear in many plants mostly as a protection agent (toxins or antifeedants) against herbivorous insects. These phytoecdysteroids have been reputed to have medicinal value and are part of herbal adaptogenic remedies like Cordyceps, yet an ecdysteroid precursor in plants has been shown to have cytotoxic properties.^[1] A pesticide sold with the name MIMIC has ecdysteroid activity, although its chemical structure has little resemblance to the ecdysteroids.

External links

Ecdybase, The Ecdysone Handbook - a free online ecdysteroids database

Notes

^ Wang YS, Yang JH, Luo SD, Zhang HB, Li L, Molecules. 2007;12(3):536-42

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UpToDate Contents

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1. 甲状腺ホルモンの作用 thyroid hormone action
2. 小児における成長ホルモン欠乏症の治療 treatment of growth hormone deficiency in children
3. 甲状腺ホルモンに対する感受性の傷害 impaired sensitivity to thyroid hormone
4. 成長ホルモン不感受性症候群 growth hormone insensitivity syndromes
5. 副甲状腺ホルモン測定およびその臨床応用 parathyroid hormone assays and their clinical use

English Journal

Dissipation and metabolism of tebufenozide in cabbage and soil under open field conditions in South China.

Liu J1, Rashid M1, Qi J1, Hu M1, Zhong G2.
Ecotoxicology and environmental safety.Ecotoxicol Environ Saf.2016 Dec;134P1:204-212. doi: 10.1016/j.ecoenv.2016.09.002. Epub 2016 Sep 14.
The novel nonsteroidal ecdysone agonist tebufenozide is capable of controlling a wide range of lepidopteran pests. However its intensive use in vegetables has raised concerns towards the safety of food and environment. Here, we developed an easy and reliable method to analyze tebufenozide in cabbage
PMID 27636325

Analysis of gene expression in the midgut of Bombyx mori during the larval molting stage.

Yang B1, Huang W1, Zhang J1, Xu Q1, Zhu S1, Zhang Q1, Beerntsen BT2, Song H3, Ling E4.
BMC genomics.BMC Genomics.2016 Nov 3;17(1):866.
BACKGROUND: Insects can be models for understanding human intestinal infection and pathology. Molting, a special period during which the old insect cuticle is shed and a new one is produced, is crucial for insect development. Holometabolous insects may experience several larva-to-larva moltings to b
PMID 27809786

Nuclear hormone receptor BmFTZ-F1 is involved in regulating the fibroin heavy chain gene in the silkworm, Bombyx mori.

Zhou C1, Zha X1, Shi P1, Zhao P1, Wang H1, Zheng R1, Xia Q2.
Biochimica et biophysica acta.Biochim Biophys Acta.2016 Nov;1860(11 Pt A):2529-36. doi: 10.1016/j.bbagen.2016.07.025. Epub 2016 Jul 28.
BACKGROUND: The synthesis of silk protein is controlled by hormones. The expression of the nuclear hormone Bmftz-f1 in the posterior silk gland (PSG) is induced by 20-hydroxyecdysone in vivo and in vitro. However, whether Bmftz-f1 regulates silk protein expression is unknown.METHODS: In our study, w
PMID 27475001

Japanese Journal

New reporter gene assays for detecting natural and synthetic molting hormone agonists using yeasts expressing ecdysone receptors of various insects

FEBS Open Bio 7(7), 995-1008, 2017-07
NAID 120006323755

脱皮ホルモン様活性化合物のQSAR

日本農薬学会誌 42(1), 38-43, 2017
NAID 130005995711

クモの脱皮とホルモン

Ａｃｔａ　Ａｒａｃｈｎｏｌｏｇｉｃａ 65(1), 55-62, 2016
NAID 130005277049

「エクジソン」

Ecdysone
Names
	IUPAC name (2S,3R,5R,9R,10R,13R,14S,17R)-17- [(2S,3R)-3,6-dihydroxy-6-methylheptan- 2-yl]-2,3,14-trihydroxy-10,13-dimethyl- 2,3,4,5,9,11,12,15,16,17-decahydro- 1H-cyclopenta[a]phenanthren-6-one
Identifiers
CAS Registry Number	3604-87-3
ChEBI	CHEBI:16688
ChEMBL	ChEMBL549300
ChemSpider	18130
	InChI InChI=1S/C27H44O6/c1-15(20(28)8-9-24(2,3)32)16-7-11-27(33)18-12-21(29)19-13-22(30)23(31)14-25(19,4)17(18)6-10-26(16,27)5/h12,15-17,19-20,22-23,28,30-33H,6-11,13-14H2,1-5H3/t15-,16+,17-,19-,20+,22+,23-,25+,26+,27+/m0/s1 ; Key: UPEZCKBFRMILAV-JMZLNJERSA-N ; InChI=1/C27H44O6/c1-15(20(28)8-9-24(2,3)32)16-7-11-27(33)18-12-21(29)19-13-22(30)23(31)14-25(19,4)17(18)6-10-26(16,27)5/h12,15-17,19-20,22-23,28,30-33H,6-11,13-14H2,1-5H3/t15-,16+,17-,19-,20+,22+,23-,25+,26+,27+/m0/s1; Key: UPEZCKBFRMILAV-JMZLNJERBR ;
Jmol-3D images	Image
PubChem	19212
	SMILES O=C1\C=C3/[C@@H]([C@]2(C[C@H](O)[C@H](O)C[C@@H]12)C)CC[C@]4([C@@]3(O)CC[C@@H]4[C@H](C)[C@H](O)CCC(O)(C)C)C ;
Properties
Chemical formula	C27H44O6
Molar mass	464.63 g/mol
	Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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	Infobox references