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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/06/19 19:06:56」(JST)

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Ecdysone is a steroidal prohormone of the major insect molting hormone 20-hydroxyecdysone, which is secreted from the prothoracic glands. Insect molting hormones (ecdysone and its homologues) are generally called ecdysteroids. Ecdysteroids act as moulting hormones of arthropods but also occur in other related phyla where they can play different roles. In Drosophila melanogaster, an increase in ecdysone concentration induces the expression of genes coding for proteins that the larva requires, and it causes chromosome puffs (sites of high expression) to form in polytene chromosomes. Ecdysteroids also appear in many plants mostly as a protection agent (toxins or antifeedants) against herbivorous insects. These phytoecdysteroids have been reputed to have medicinal value and are part of herbal adaptogenic remedies like Cordyceps, yet an ecdysteroid precursor in plants has been shown to have cytotoxic properties.^[1] A pesticide sold with the name MIMIC has ecdysteroid activity, although its chemical structure has little resemblance to the ecdysteroids.

External links[edit]

Ecdybase, The Ecdysone Handbook - a free online ecdysteroids database

Notes[edit]

^ Wang YS, Yang JH, Luo SD, Zhang HB, Li L, Molecules. 2007;12(3):536-42

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English Journal

Assessment of resistance risk in Musca domestica L. (Diptera: Muscidae) to methoxyfenozide.

Shah RM1, Abbas N2, Shad SA3.
Acta tropica.Acta Trop.2015 Sep;149:32-7. doi: 10.1016/j.actatropica.2015.05.009. Epub 2015 May 15.
Methoxyfenozide, an ecdysone receptor agonist is an effective larvicide against many pests of public health and veterinary importance including house fly, Musca domestica L. (Diptera: Muscidae). Methoxyfenozide is a bio-rational insecticide having many environmentally friendly attributes that make i
PMID 25985910

β-Ecdysone Augments Peak Bone Mass in Mice of Both Sexes.

Dai W1, Zhang H, Zhong ZA, Jiang L, Chen H, Lay YA, Kot A, Ritchie RO, Lane NE, Yao W.
Clinical orthopaedics and related research.Clin Orthop Relat Res.2015 Aug;473(8):2495-504. doi: 10.1007/s11999-015-4246-5.
BACKGROUND: One of the strongest predictors for osteoporosis is peak bone mass. Interventions to augment peak bone mass have yet to be developed. β-Ecdysone (βEcd), a natural steroid-like compound produced by arthropods to initiate metamorphosis, is believed to have androgenic effects and so may b
PMID 25822452

Acetylations of Ftz-F1 and histone H4K5 are required for the fine-tuning of ecdysone biosynthesis during Drosophila metamorphosis.

Borsos BN1, Pankotai T2, Kovács D1, Popescu C1, Páhi Z1, Boros IM3.
Developmental biology.Dev Biol.2015 Aug 1;404(1):80-7. doi: 10.1016/j.ydbio.2015.04.020. Epub 2015 May 8.
The molting during Drosophila development is tightly regulated by the ecdysone hormone. Several steps of the ecdysone biosynthesis have been already identified but the regulation of the entire process has not been clarified yet. We have previously reported that dATAC histone acetyltransferase comple
PMID 25959239

Japanese Journal

Ecdysone differentially regulates metamorphic timing relative to 20-hydroxyecdysone by antagonizing juvenile hormone in Drosophila melanogaster.

Ono Hajime
Developmental biology 391(1), 32-42, 2014-07-01
… In insects, a steroid hormone, 20-hydroxyecdysone (20E), plays important roles in the regulation of developmental transitions by initiating signaling cascades via the ecdysone receptor (EcR). … Although 20E has been well characterized as the molting hormone, its precursor ecdysone (E) has been considered to be a relatively inactive compound because it has little or no effect on classic EcR mediated responses. …
NAID 120005439529

cDNA cloning of ecdysone receptor (EcR) and ultraspiracle (USP) from Harmonia axyridis and Epilachna vigintioctopunctata and the evaluation of the binding affinity of ecdysone agonists to the in vitro translated EcR/USP heterodimers

MORISHITA China,MINAKUCHI Chieka,YOKOI Taiyo [他]
Journal of pesticide science 39(1・2), 76-84, 2014
NAID 40020065703

Identification of a DNA sequence critical for ecdysone receptor binding to the distal promoter of the Bombyx Broad-Complex gene

Nishita Yoshinori
Journal of insect biotechnology and sericology 82(3), 71-78, 2013-10
NAID 40020110812

Related Pictures

★リンクテーブル★

リンク元	「エクジソン」「molting hormone」
拡張検索	「hydroxyecdysone」

「エクジソン」

Ecdysone
	IUPAC name (2S,3R,5R,9R,10R,13R,14S,17R)-17- [(2S,3R)-3,6-dihydroxy-6-methylheptan- 2-yl]-2,3,14-trihydroxy-10,13-dimethyl- 2,3,4,5,9,11,12,15,16,17-decahydro- 1H-cyclopenta[a]phenanthren-6-one
Identifiers
CAS number	3604-87-3
PubChem	19212
ChemSpider	18130
ChEBI	CHEBI:16688
ChEMBL	CHEMBL549300
Jmol-3D images	Image 1
	SMILES O=C1\C=C3/[C@@H]([C@]2(C[C@H](O)[C@H](O)C[C@@H]12)C)CC[C@]4([C@@]3(O)CC[C@@H]4[C@H](C)[C@H](O)CCC(O)(C)C)C ;
	InChI InChI=1S/C27H44O6/c1-15(20(28)8-9-24(2,3)32)16-7-11-27(33)18-12-21(29)19-13-22(30)23(31)14-25(19,4)17(18)6-10-26(16,27)5/h12,15-17,19-20,22-23,28,30-33H,6-11,13-14H2,1-5H3/t15-,16+,17-,19-,20+,22+,23-,25+,26+,27+/m0/s1 ; Key: UPEZCKBFRMILAV-JMZLNJERSA-N InChI=1/C27H44O6/c1-15(20(28)8-9-24(2,3)32)16-7-11-27(33)18-12-21(29)19-13-22(30)23(31)14-25(19,4)17(18)6-10-26(16,27)5/h12,15-17,19-20,22-23,28,30-33H,6-11,13-14H2,1-5H3/t15-,16+,17-,19-,20+,22+,23-,25+,26+,27+/m0/s1; Key: UPEZCKBFRMILAV-JMZLNJERBR ;
Properties
Molecular formula	C27H44O6
Molar mass	464.63 g/mol
	(verify) (what is: /?); Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
	Infobox references