ミトコンドリア内膜

関: inner mitochondrial membrane

WordNet

located or occurring within or closer to a center; "an inner room"
located inward; "Beethovens manuscript looks like a bloody record of a tremendous inner battle"- Leonard Bernstein; "she thinks she has no soul, no interior life, but the truth is that she has no access to it"- David Denby; "an internal sense of rightousness"- A.R.Gurney,Jr. (同)interior, internal
innermost or essential; "the inner logic of Cubism"; "the internal contradictions of the theory"; "the intimate structure of matter" (同)internal, intimate
exclusive to a center; especially a center of influence; "inner regions of the organization"; "inner circles of government"
inside or closer to the inside of the body; "the inner ear"
a thin pliable sheet of material
a pliable sheet of tissue that covers or lines or connects the organs or cells of animals or plants (同)tissue layer

PrepTutorEJDIC

『内側の』,『内部の』,奥の / 『精神の』,心の / 親密な;内密の
(生物の)膜,皮膜
『宿屋』,小さな旅館

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/11 20:02:48」(JST)

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[Wiki en表示]

The inner mitochondrial membrane (IMM) is the mitochondrial membrane which separates the mitochondrial matrix from the intermembrane space.

Structure

The structure of the inner mitochondrial membrane is extensively folded and compartmentalized. The numerous invaginations of the membrane are called cristae, separated by crista junctions from the inner boundary membrane juxtaposed to the outer membrane. Cristae significantly increase the total membrane surface area compared to a smooth inner membrane and thereby the available working space.

The inner membrane creates two compartments. The region between the inner and outer membrane, called the intermembrane space which is largely continuous with the cytosol, and the more sequestered space inside the inner membrane, called matrix.

Cristae

For typical liver mitochondria, the area of the inner membrane is about 5x as large as the outer membrane due to cristae. This ratio is variable and mitochondria from cells that have a greater demand for ATP, such as muscle cells, contain even more cristae. Cristae membranes are studded on the matrix side with small round protein complexes known as F₁ particles, the site of proton-gradient driven ATP synthesis. Cristae affect overall chemiosmotic function of mitochondria.^[1]

Cristae junctions

Cristae and the inner boundary membranes are separated by junctions. The end of cristae are partially closed by transmembrane protein complexes that bind head to head and link opposing crista membranes in a bottleneck-like fashion.^[2] For example, deletion of the junction protein Mitofilin/Fcj1 leads to a reduced inner membrane potential and impaired growth ^[3] and to dramatically aberrant inner membrane structures which form concentric stacks instead of the typical invaginations.^[4]

Composition

The inner membrane of mitochondria is similar in lipid composition to the membrane of bacteria. This phenomenon can be explained by the endosymbiont hypothesis of the origin of mitochondria as prokaryotes internalized by a eukaryotic host cell.

In pig heart mitochondria, phosphatidylethanolamine makes up the majority of the inner mitochondrial membrane at 37.0% of the phospholipid composition. Phosphatidylcholine makes up about 26.5%, cardiolipin 25.4%, and phosphatidylinositol 4.5%.^[5] In S. cerevisiae mitochondria, phosphatidylcholine makes up 38.4% of the IMM, phosphatidylethanolamine makes up 24.0%, phosphatidylinositol 16.2%, cardiolipin 16.1%, phosphatidylserine 3.8%, and phosphatidic acid 1.5%.^[6]

In the inner mitochondrial membrane, the protein-to-lipid ratio is 80:20, in contrast to the outer membrane, which is 50:50.^[7]

Permeability

The inner membrane is freely permeable only to oxygen, carbon dioxide, and water.^[8] It is much less permeable to ions and small molecules than the outer membrane, creating compartments by separating the matrix from the cytosolic environment. This compartmentalization is a necessary feature for metabolism. The inner mitochondrial membrane is both an electrical insulator and chemical barrier. Sophisticated ion transporters exist to allow speciﬁc molecules to cross this barrier. There are several antiport systems embedded in the inner membrane, allowing exchange of anions between the cytosol and the mitochondrial matrix.^[7]

IMM-associated proteins

Electron transport chain

NADH dehydrogenase (ubiquinone)
Electron-transferring-flavoprotein dehydrogenase
Electron-transferring flavoprotein
Succinate dehydrogenase
Alternative oxidase
Cytochrome bc1 complex
Cytochrome c
Cytochrome c oxidase
F-ATPase

ATP–ADP translocase
ATP-binding cassette transporter
Cholesterol side-chain cleavage enzyme
Protein tyrosine phosphatase
Carnitine O-palmitoyltransferase
Carnitine O-acetyltransferase
Carnitine O-octanoyltransferase
Cytochrome P450
Translocase of the inner membrane
Glutamate aspartate transporter
Pyrimidine metabolism

Dihydroorotate dehydrogenase
Thymidylate synthase (FAD)

HtrA serine peptidase 2
Adrenodoxin reductase
Heme biosynthesis

Protoporphyrinogen oxidase
Ferrochelatase

Uncoupling protein

External links

Mitochondrial inner membrane (55 proteins) Orientations of Proteins in Membranes (OPM) database
http://www.med.uiuc.edu/histo/small/atlas/objects/1340.htm

References

^ Mannella CA (2006). "Structure and dynamics of the mitochondrial inner membrane cristae". Biochimica et Biophysica Acta 1763 (5–6): 542–548. doi:10.1016/j.bbamcr.2006.04.006. PMID 16730811.
^ <pubmed>22014515</pubmed>
^ <pubmed>21944719</pubmed>
^ <pubmed>19528297</pubmed>
^ Comte J, Maïsterrena B, Gautheron DC (January 1976). "Lipid composition and protein profiles of outer and inner membranes from pig heart mitochondria. Comparison with microsomes". Biochim. Biophys. Acta 419 (2): 271–84. doi:10.1016/0005-2736(76)90353-9. PMID 1247555. Retrieved 2014-04-09.
^ Lomize, Andrel; Lomize, Mikhail; Pogozheva, Irina (2013). "Membrane Protein Lipid Composition Atlas". Orientations of Proteins in Membranes. University of Michigan. Retrieved 10 April 2014.
^ ^a ^b Krauss, Stefan (2001). "Mitochondria: Structure and Role in Respiration" (PDF). Nature Publishing Group. Retrieved 9 April 2014.
^ Caprette, David R. (12 December 1996). "Structure of Mitochondria". Experimental Biosciences. Rice University. Retrieved 9 April 2014.

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関連記事	「inner」「mitochondrial」「membrane」

「inner」

Cell biology
	The mitochondrion
	Components of a typical mitochondrion 1 Outer membrane; 1.1 Porin; 2 Intermembrane space; 2.1 Intracristal space; 2.2 Peripheral space; 3 Lamella; 3.1 Inner membrane ◄ You are here; 3.11 Inner boundary membrane; 3.12 Cristal membrane; 3.2 Matrix; 3.3 Cristæ; 4 Mitochondrial DNA; 5 Matrix granule; 6 Ribosome; 7 ATP synthase ;

　　[★]

adj.

内側の

関: inside、interior、medial、medialis、medially

「mitochondrial」

　　[★]

adj.

ミトコンドリアの

関: mitochondria、mitochondrially、mitochondrion

「membrane」

　　[★]

n.

膜、メンブラン

[Mannella-1] Mannella CA (2006). "Structure and dynamics of the mitochondrial inner membrane cristae". Biochimica et Biophysica Acta 1763 (5–6): 542–548. doi:10.1016/j.bbamcr.2006.04.006. PMID 16730811.

[2] <pubmed>22014515</pubmed>

[3] <pubmed>21944719</pubmed>

[4] <pubmed>19528297</pubmed>

[pmid1247555-5] Comte J, Maïsterrena B, Gautheron DC (January 1976). "Lipid composition and protein profiles of outer and inner membranes from pig heart mitochondria. Comparison with microsomes". Biochim. Biophys. Acta 419 (2): 271–84. doi:10.1016/0005-2736(76)90353-9. PMID 1247555. Retrieved 2014-04-09.

[6] Lomize, Andrel; Lomize, Mikhail; Pogozheva, Irina (2013). "Membrane Protein Lipid Composition Atlas". Orientations of Proteins in Membranes. University of Michigan. Retrieved 10 April 2014.

[Krauss-7] Krauss, Stefan (2001). "Mitochondria: Structure and Role in Respiration" (PDF). Nature Publishing Group. Retrieved 9 April 2014.

[Rice-8] Caprette, David R. (12 December 1996). "Structure of Mitochondria". Experimental Biosciences. Rice University. Retrieved 9 April 2014.

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mitochondrial inner membrane