ミンク腸炎ウイルス

WordNet

a harmful or corrupting agency; "bigotry is a virus that must not be allowed to spread"; "the virus of jealousy is latent in everyone"
(virology) ultramicroscopic infectious agent that replicates itself only within cells of living hosts; many are pathogenic; a piece of nucleic acid (DNA or RNA) wrapped in a thin coat of protein
a software program capable of reproducing itself and usually capable of causing great harm to files or other programs on the same computer; "a true virus cannot spread to another computer without human assistance" (同)computer virus
the expensive fur of a mink
fur coat made from the soft lustrous fur of minks (同)mink coat
slender-bodied semiaquatic mammal having partially webbed feet; valued for its fur
the act of extracting ores or coal etc from the earth (同)excavation
laying explosive mines in concealed places to destroy enemy personnel and equipment (同)minelaying
the syllable naming the third (mediant) note of any major scale in solmization
inflammation of the intestine (especially the small intestine); usually characterized by diarrhea

PrepTutorEJDIC

ビールス,ろ過性病原体
〈C〉ミンク(イタチに似た動物) / 〈U〉ミンクの毛皮(光沢のある茶色で,高価) / ミンクの
採鉱,鉱業 / 地雷(機雷)の敷設 / 鉱山の,採鉱の
ミ(全音階の第3音)
腸炎

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/02/27 20:44:14」(JST)

wiki en

Mink enteritis virus (MEV) is a species of parvovirus that infects mink and causes enteritis. Like all parvoviruses, it is a small (18–26 nm), spherical virus, and has a single-stranded DNA genome. The signs and symptoms of enteritis usually appear within 4–7 days after infection. The virus replicates in the cells of the crypt epithelium in the duodenum and jejunum and, to a lesser extent the ileum, colon and caecum. The severity of the disease is directly related to necrosis of the crypt epithelium. ^[1]

Virus enteritis of mink was recognized first in 1947 when epizootics occurred among ranch mink in southern Canada. The disease subsequently spread to the United States^[2] and Europe.^[3]

Signs and symptoms

Clinical signs include anorexia, vomiting and severe diarrhoea. Stools of affected animals usually contain large quantities of mucus and intestinal casts or "plugs" composed of fibrin, mucus and dead cells from intestinal mucosa. In immature animals, anorexia and diarrhoea usually occur about four days after exposure to infectious material and persist for four to seven days. However, infections have been reported in which anorexia was followed by death in 12 to 24 hours without the occurrence of diarrhoea. Mortality of 80 percent or more is possible in newly-weaned kits. Mature mink often survive the disease after a period of sickness which may last several weeks. In addition to the overt signs a reduction of the number of leukocytes in the blood may be found in affected animals.^[2]

Treatment

Treatment consists of oral rehydration therapy in addition to supportive care. Surgical removal of necrotic tissue may be necessary.

References

^ Collier, Leslie; Balows, Albert; Sussman Max (1998) Topley and Wilson's Microbiology and Microbial Infections ninth edition, Volume 1, Virology, volume editors: Mahy, Brian and Collier, Leslie. p. 268 Arnold. ISBN 0-340-66316-2
^ ^a ^b Reynolds HA (April 1969). "Some clinical and hematological features of virus enteritis of mink". Can. J. Comp. Med. 33 (2): 155–9. PMC 1319402. PMID 4238566. //www.ncbi.nlm.nih.gov/pmc/articles/PMC1319402/. Retrieved 2008-12-28.
^ Flagstad A (1977). "Feline panleukopaenia virus and mink enteritis virus. A serological study". Acta Vet. Scand. 18 (1): 1–9. PMID 66862.

UpToDate Contents

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1. 小児におけるウイルス性胃腸炎：疫学、病因、臨床症状および診断 viral gastroenteritis in children epidemiology clinical presentation and diagnosis
2. 成人におけるウイルス性胃腸炎の疫学および病因 epidemiology and pathogenesis of viral gastroenteritis in adults
3. 小児におけるウイルス性胃腸炎：予防および治療 viral gastroenteritis in children prevention and treatment
4. 成人における急性ウイルス性胃腸炎 acute viral gastroenteritis in adults
5. 新生児集中治療室における院内ウイルス感染症 nosocomial viral infections in the neonatal intensive care unit

English Journal

MicroRNA profile analysis of a feline kidney cell line before and after infection with mink enteritis virus.

Sun JZ1, Wang J1, Wang S1, Yuan D1, Birame BM1, Li Z1, Yi B1, Liu W2.Author information 1State Key Laboratory of Agrobiotechnology, Department of Biochemistry and Molecular Biology, College of Biological Sciences, China Agricultural University, Beijing 100193, China.2State Key Laboratory of Agrobiotechnology, Department of Biochemistry and Molecular Biology, College of Biological Sciences, China Agricultural University, Beijing 100193, China. Electronic address: weiquan8@cau.edu.cn.AbstractMicroRNAs (miRNAs) are small regulatory RNAs that play a significant role in eukaryotes by targeting mRNAs for cleavage or translational repression. Recent studies have also shown them to be associated with cellular changes following viral infection. Mink enteritis virus (MEV) is one of the most important viral pathogens in the mink industry. To study the involvement of miRNAs in the MEV infection process, we used Illumina's ultra high throughput approach to sequencing miRNA libraries from the feline kidney (F81) cell line before and after infection with MEV. Using this bioinformatics approach we identified 196 known mammalian miRNA orthologs belonging to 152 miRNA families in F81 cells. Additionally, 97 miRNA*s of these miRNAs were detected. As well as known miRNAs, 384 and 398 novel miRNA precursor candidates were identified in uninfected and MEV-infected F81 cells respectively that have not been reported in other mammals. In MEV-infected cells 3 miRNAs were significantly down-regulated, and 4 up-regulated including 3 significantly. The majority (12 of 16) of randomly selected miRNAs expression profiles by qRT-PCR were consistent with those identified by deep sequencing. A total of 88 miRNAs were predicted to target interferon-associated genes; 6 appear to target the 3'UTR of MEV-specific receptor transferring receptor mRNAs; and 8 to target the MEV NS1 mRNA coding region. No miRNAs coded by MEV itself were detected.
Gene.Gene.2014 Feb 10. pii: S0378-1119(14)00151-6. doi: 10.1016/j.gene.2014.01.074. [Epub ahead of print]
MicroRNAs (miRNAs) are small regulatory RNAs that play a significant role in eukaryotes by targeting mRNAs for cleavage or translational repression. Recent studies have also shown them to be associated with cellular changes following viral infection. Mink enteritis virus (MEV) is one of the most imp
PMID 24525403

Establishment of a rescue system for an autonomous Parvovirus mink enteritis virus.

Yuan D1, Wang J1, Li Z1, Mao Y1, Sun JZ1, Xi J1, Wang S1, Hou Q1, Yi B1, Liu W2.Author information 1State Key Laboratory of Agrobiotechnology, Department of Biochemistry and Molecular Biology, College of Biological Sciences, China Agricultural University, Beijing 100193, PR China.2State Key Laboratory of Agrobiotechnology, Department of Biochemistry and Molecular Biology, College of Biological Sciences, China Agricultural University, Beijing 100193, PR China. Electronic address: weiquan6273@126.com.AbstractConstruction and characterization of a full-length infectious clone (pMEV) of mink enteritis virus are described. Feline kidney cells (F81) were transfected with pMEV containing an engineered BamHI site that served as a genetic marker. The rescued virus was indistinguishable from its parental virus. The availability of a MEV infectious clone will facilitate studies of viral replication and pathogenicity and will permit the elucidation of determinants of the host range of the parvovirus.
Virus research.Virus Res.2014 Jan 22;183C:1-5. doi: 10.1016/j.virusres.2014.01.012. [Epub ahead of print]
Construction and characterization of a full-length infectious clone (pMEV) of mink enteritis virus are described. Feline kidney cells (F81) were transfected with pMEV containing an engineered BamHI site that served as a genetic marker. The rescued virus was indistinguishable from its parental virus.
PMID 24463297

Genome Sequence of Mink Enteritis Virus Strain SD 12/01, Isolated from a Mink with Severe Diarrhea in China.

Wang J, Zhao H, Cheng Y, Yi L, Cheng S.Author information State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Economic Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun, Jilin, China.AbstractThe mink enteritis virus (MEV) SD12/01 strain was isolated from a mink showing clinical and pathological signs of enteritis in Shandong, China, in 2012. The genome of MEV SD12/01 was sequenced and analyzed, which will promote a better understanding of the molecular epidemiology and genetic diversity of MEV field isolates in northern China.
Genome announcements.Genome Announc.2013 Jun 20;1(3). pii: e00306-13. doi: 10.1128/genomeA.00306-13.
The mink enteritis virus (MEV) SD12/01 strain was isolated from a mink showing clinical and pathological signs of enteritis in Shandong, China, in 2012. The genome of MEV SD12/01 was sequenced and analyzed, which will promote a better understanding of the molecular epidemiology and genetic diversity
PMID 23788538

Japanese Journal

Successive Deaths of a Captive Snow Leopard (Uncia uncia) and a Serval (Leptailurus serval) by Infection with Feline Panleukopenia Virus at Sapporo Maruyama Zoo

Sassa Yukiko,Yamamoto Hideaki,Mochizuki Masami [他],UMEMURA Takashi,HORIUCHI Motohiro,ISHIGURO Naotaka,MIYAZAWA Takayuki
Journal of Veterinary Medical Science 73(4), 491-494, 2011
… Isolates possessed an antigenic epitope for both the feline panleukopenia virus (FPLV) and mink enteritis virus, identified with a hemagglutination inhibition test. … These results suggested that FPLV was introduced from a feral cat which entered the zoo and transmitted the virus inside the zoo. …
NAID 130000444502

猫用市販3種混合不活化ワクチンを接種した展示ネコ科動物におけるネコパルボウイルスに対する中和抗体(ウイルス学)

佐々悠木子,福井大祐,武士甲一 [他],宮沢孝幸
The journal of veterinary medical science 68(11), 1195-1198, 2006-11-25
ネコ汎白血球減少症ウイルスをもとにした猫用市販3種混合ワクチンを接種した展示ネコ科動物で,パルボウイルスの各抗原型に対する中和抗体価を測定した.すべての個体は交差中和抗体を有していたものの,ライオンおよびシベリアンタイガーでは,イヌパルボウイルス2型および2c型に対して極めて低い抗体価が観察された.展示ネコ科動物の種類によっては,市販の3種混合ワクチンの有効性に注意を払う必要があると考えられた.
NAID 110005664040

猫汎白血球減少症ウイルスおよびミンク腸炎ウイルスに特異的なモノクローナル抗体のエピトープの同定(短報)

堀内基広,望月雅美,石黒直隆 [他],長澤秀行,品川森一
The journal of veterinary medical science 59(2), 133-136, 1997-02-25
猫汎白血球減少症ウイルス中(FPLV)およびミンク腸炎ウイルス(MEV)に特異的なモノクローナル抗体(MAb)を得る目的で, MEV-網走株に対する15株のMAbを作製した. 一つのMAb P2-215はFPLVおよびMEVに特異的であったが, 残りの14のMAbはイヌパルボウイルス(CPV), FPLV, MEVすべてに反応した. CPV/MEVキメラウイルスを用いたエピトープ解析から, MAb …
NAID 110003915113