巨赤芽球
WordNet
- abnormally large red blood cell present in pernicious anemia and folic acid deficiency
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/06/10 20:19:25」(JST)
[Wiki en表示]
A megaloblast is an unusually large erythroblast that can be associated with Vitamin B12 deficiency (as caused by pernicious anemia or dietary insufficiency) and/or folic acid deficiency (collectively called megaloblastic anemia). It is differentiated from a normoblast, which is a normally-sized erythroblast. This kind of anemia leads to macrocytes (abnormally large red cells). The cause of this cellular gigantism is an impairment in DNA synthesis which delays nuclear maturation and cell division. Because RNA and cytoplasmic elements are synthesized at a constant rate despite the cells' impaired DNA synthesis, the cells show nuclear-cytoplasmic asynchrony.
Additional images
See also
- Erythropoiesis
- Hemopoiesis
- Pluripotential hemopoietic stem cell
External links
- Pronormoblasts Presented by the University of Virginia
- Basophilic Normoblasts Presented by the University of Virginia
- Polychromatophilic Normoblasts Presented by the University of Virginia
- Orthochromatic Normoblasts Presented by the University of Virginia
- "Megaloblast" at Dorland's Medical Dictionary
- "Normoblast" at Dorland's Medical Dictionary
- "Erythroblast" at Dorland's Medical Dictionary
- Normoblasts at the US National Library of Medicine Medical Subject Headings (MeSH)
- Histology image: 01804loa – Histology Learning System at Boston University - "Bone Marrow and Hemopoiesis bone marrow smear, erythroblast series with proerythroblast "
- Histology at uiowa.edu
The main cell types in blood
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Cellular/
HSCs |
Myeloid/
CFU-GEMM |
CFU-GM |
CFU-G:
Granulocytes |
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CFU-M:
Monocytes/
MPS |
Macrophages |
- Histiocytes
- Kupffer cells
- Alveolar macrophage
- Microglia
- Osteoclasts
- Epithelioid cells
- giant cells
- Langhans giant cells, Foreign-body giant cell
- Touton giant cells
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CFU-DL |
- Dendritic cells
- Langerhans cell
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Common |
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CFU-Baso |
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CFU-Eos |
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MEP |
CFU-Meg |
- Megakaryoblast
- Promegakaryocyte
- Megakaryocyte
- Platelets
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CFU-E |
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CFU-Mast |
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Noncellular |
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UpToDate Contents
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English Journal
- Evaluation of Macrocytic Anemias.
- Green R1, Dwyre DM2.
- Seminars in hematology.Semin Hematol.2015 Oct;52(4):279-86. doi: 10.1053/j.seminhematol.2015.06.001. Epub 2015 Jun 30.
- Macrocytic anemia, defined as a mean cell volume (MCV) ≥100 fL in adults, has a narrow differential diagnosis that requires evaluation of the peripheral blood smear as well as additional laboratory testing taken in conjunction with clinical information that includes patient history and physical ex
- PMID 26404440
- Hydroxyurea increases plasma concentrations of microparticles and reduces coagulation activation and fibrinolysis in patients with sickle cell anemia.
- Brunetta DM1, De Santis GC, Silva-Pinto AC, Oliveira de Oliveira LC, Covas DT.
- Acta haematologica.Acta Haematol.2015;133(3):287-94. doi: 10.1159/000362148. Epub 2014 Dec 2.
- Microparticles (MPs) are present in healthy subjects and their concentration increases in patients at high risk of thrombosis. We evaluated 10 patients with sickle cell anemia (SCA) treated with hydroxyurea (HU) and 13 SCA patients without this treatment. MP concentrations were determined by flow cy
- PMID 25472687
- Using surface-assisted laser desorption/ionization mass spectrometry to detect ss- and ds-oligodeoxynucleotides.
- Chen WT1, Huang MF, Chang HT.
- Journal of the American Society for Mass Spectrometry.J Am Soc Mass Spectrom.2013 Jun;24(6):877-83. doi: 10.1007/s13361-013-0595-z. Epub 2013 Mar 29.
- We applied surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) with HgTe nanostructures as the matrix for the detection of single- and double-stranded oligodeoxynucleotides (ss-ODNs and ds-ODNs). The concentrations of surfactant and additives (metal ions, an amine) and the pH a
- PMID 23539494
Japanese Journal
- 1型糖尿病と慢性甲状腺炎に悪性貧血を合併した自己免疫性多内分泌腺症候群(APS)3型の1症例
- 村井 大毅,山本 恒彦,東 大介 [他],光井 絵理,林 功,橋本 光司,久保田 稔
- 糖尿病 57(10), 797-804, 2014
- 症例は74歳女性.1990年より慢性甲状腺炎に対してレボチロキシン,2008年に1型糖尿病を発症し強化インスリン療法を施行していた.2011年8月,全身倦怠感・食思不振を自覚し,近医を受診し,高度の貧血を認めたため当院内科に緊急入院となった.大球性貧血,Vit.B12測定感度以下,抗内因子抗体陽性,高度の萎縮性胃炎を認めた.骨髄所見では,大型の赤芽球系細胞の過形成を認め,悪性貧血と診断した.Vit …
- NAID 130004706114
- Huge multinucleated megaloblasts found in a patient with refractory anemia with excess blasts-1
- OHGIYA Daisuke,MATSUSHITA Hiromichi,KOJIMA Minoru,ANDO Kiyoshi
- International journal of hematology 96(5), 531-532, 2012-11-01
- NAID 10031126748
- Slowly Progressive Type 1 Diabetes Mellitus Associated with Vitiligo Vulgaris, Chronic Thyroiditis, and Pernicious Anemia
- , , [他], , ,
- Internal medicine 43(12), 1183-1185, 2004-12-01
- … Low serum vitamin B12 levels and the finding of erythroblastic hyperplasia with megaloblasts in bone marrow led to the diagnosis of pernicious anemia. …
- NAID 10014210133
Related Links
- megaloblast [meg´ah-lo-blast″] a large, nucleated immature progenitor of an abnormal erythrocytic series, an abnormal counterpart to the normoblast; megaloblasts are present in the blood in certain anemias. adj., adj megaloblas´tic.
- Important It is possible that the main title of the report Anemia, Megaloblastic is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this ...
Related Pictures
★リンクテーブル★
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- 英
- megaloblast, megaloblasts
- 関
- 赤芽球
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