蝶形紅斑、頬部発疹
WordNet
- imprudently incurring risk; "do something rash that he will forever repent"- George Meredith
- any red eruption of the skin (同)roseola, efflorescence, skin_rash
- a series of unexpected and unpleasant occurrences; "a rash of bank robberies"; "a blizzard of lawsuits" (同)blizzard
PrepTutorEJDIC
- (人・行動などが)『向こう見ずな』,無分別な(reckless);性急な
- 発疹(はっしん)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/09/22 22:42:03」(JST)
[Wiki en表示]
In medicine, malar rash (from Latin mala ‘jaw, cheek-bone’), also called butterfly rash, is a medical sign consisting of a characteristic form of facial rash. It is often seen in Lupus erythematosus but is not pathognomonic - it is also seen in other diseases such as Pellagra, dermatomyositis and Bloom Syndrome.
The malar rash of lupus is red or purplish and mildly scaly. Characteristically, it has the shape of a butterfly and involves the bridge of the nose. Notably, the rash spares the nasolabial folds of the face, which contributes to its characteristic appearance. It is usually macular with sharp edges and not itchy. The rash can be transient or progressive with involvement of other parts of the facial skin.
A malar rash is present in approximately 46-65% of lupus sufferers and varies between different populations.[1][1][2]
There are numerous other conditions which can cause rashes with a similar appearance. Where lupus is suspected further medical tests (usually an ANA as a screening test which is not specific for systemic lupus erythematosus) and a detailed history and examination are necessary to differentiate it from other conditions.
Trivia
Pop singer Seal has a malar rash on his face due to discoid lupus.
References
- ^ a b Houman M, Smiti-Khanfir M, Ben Ghorbell I, Miled M (2004). "Systemic lupus erythematosus in Tunisia: demographic and clinical analysis of 100 patients". Lupus 13 (3): 204–11. doi:10.1191/0961203303lu530xx. PMID 15119551.
- ^ Vilá L, Alarcón G, McGwin G, Friedman A, Baethge B, Bastian H, Fessler B, Reveille J (2004). "Early clinical manifestations, disease activity and damage of systemic lupus erythematosus among two distinct U.S. Hispanic subpopulations". Rheumatology (Oxford) 43 (3): 358–63. doi:10.1093/rheumatology/keh048. PMID 14623949.
External links
- http://library.med.utah.edu/WebPath/IMMHTML/IMM009.html
- http://www.nlm.nih.gov/medlineplus/ency/imagepages/2507.htm
UpToDate Contents
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English Journal
- FcγRIIa and FcγRIIIb polymorphisms and associations with clinical manifestations in systemic lupus erythematosus patients.
- Vigato-Ferreira IC1, Toller-Kawahisa JE, Pancoto JA, Mendes-Junior CT, Martinez EZ, Donadi EA, Louzada-Júnior P, Del Lama JE, Marzocchi-Machado CM.
- Autoimmunity.Autoimmunity.2014 Nov;47(7):451-8. doi: 10.3109/08916934.2014.921809. Epub 2014 Jun 4.
- Abstract In this study, we aimed to investigate whether the distribution of the FcγRIIa and FcγRIIIb polymorphisms determines susceptibility to systemic lupus erythematosus (SLE) and acts as predictors of SLE clinical manifestations in the Brazilian patients. A total of 157 patients that fulfilled
- PMID 24896836
- A nationwide study of SLE in Japanese identified subgroups of patients with clear signs patterns and associations between signs and age or sex.
- Terao C1, Yamada R2, Mimori T3, Yamamoto K4, Sumida T5.
- Lupus.Lupus.2014 Nov;23(13):1435-42. doi: 10.1177/0961203314547790. Epub 2014 Aug 13.
- We performed a nationwide study to determine the distributions of the signs and clinical markers of systemic lupus erythematosus (SLE) and identify any patterns in their distributions to allow patient subclassification. We obtained 256,999 patient-year records describing the disease status of SLE pa
- PMID 25122185
- Emerging role of SIGIRR rs7396562(T/G) polymorphism in systemic lupus erythematosus in a Chinese population.
- Zhu Y1, Wang DG, Yang XK, Tao SS, Huang Q, Pan HF, Feng CC, Ye DQ.
- Inflammation.Inflammation.2014 Oct;37(5):1847-51. doi: 10.1007/s10753-014-9916-z.
- Systemic lupus erythematosus (SLE) is a systemic autoimmune disease, with heterogeneous presentation. The aim of this study was to examine the association of a single-nucleotide polymorphism, rs7396562, of the interferon induced with single immunoglobulin IL-1-related receptor (SIGIRR) gene with SLE
- PMID 24826913
Japanese Journal
- 原発性胆汁性肝硬変に全身性エリテマトーデスを合併した2例
- 斎藤 広信,高橋 敦史,阿部 和道 [他],物江 恭子,菅野 有紀子,横川 順子,大平 弘正
- 肝臓 52(3), 169-175, 2011-03-25
- 症例1は65歳，女性．19年前，蝶形紅斑と光線過敏があり，抗核抗体陽性，抗DNA抗体陽性を認め，SLEと診断された．プレドニゾロン（PSL）内服にて症状は改善し，PSL 10 mg/日の隔日投与でSLEの活動性はなく経過していた．SLE診断時から肝機能異常があり，精査目的に当科へ紹介となった．胆道系酵素優位の肝障害，抗ミトコンドリア抗体（AMA）陽性，肝生検にてPBC（Scheuer分類のII期） …
- NAID 10029285191
- 田端 理英,田端 千春,北 祥男,波内 俊三,寺田 信,永井 朝子
- 日本臨床免疫学会会誌 = Japanese journal of clinical immunology 32(2), 116-123, 2009-04-28
- 78歳，82歳という高齢発症SLE（LO-SLE）が疑われる2症例に合併した血球貪食症候群（HPS）を経験した．2例とも食思不振を主訴とし，SLEに特徴的な症状は無かった．明らかな感染の認められない発熱，血球減少，胸膜炎，心膜炎，肝障害，血液凝固異常などを呈し，骨髄穿刺にて血球貪食組織球を認め，自己抗体の存在よりHPS合併LO-SLEに矛盾しないと判断した．一例は中等量のス …
- NAID 10024962139
- 出産を契機に血球貪食症候群を伴い発症した全身性エリテマトーデスの1例
- 吉田 周造,武内 徹,伊丹 康夫,秦 健一郎,渡辺 香子,庄田 武司,小谷 卓矢,槇野 茂樹,花房 俊昭
- 日本臨床免疫学会会誌 = Japanese journal of clinical immunology 32(1), 66-70, 2009-02-28
- 症例は33歳，女性．2007年3月15日第1子出産．約3週間後より発熱，リンパ節腫脹，頬部紅斑が出現したため，同年6月13日当院入院した．汎血球減少，フェリチン上昇を認め，骨髄穿刺にてマクロファージによる血球貪食像を認め，血球貪食症候群（HPS）と診断した．また，抗核抗体陽性，抗ds-DNA抗体陽性，検尿異常を認め，全身性エリテマトーデス（SLE）と診断した．Prednis …
- NAID 10024961974
★リンクテーブル★
[★]
- 英
- butterfly erythema, butterfly rash
- 同
- malar rash?
- 関
- 全身性エリテマトーデス
[★]
- 日
- 発疹, 皮疹
- 関
- skin lesions
[★]