マクログロブリン
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/12/20 04:09:10」(JST)
[Wiki en表示]
IgM, pictured, is an example of a macroglobulin. Another example is alpha-2 macroglobulin.
A macroglobulin is a plasma globulin of high molecular weight. [1]
Elevated levels of macroglobulins (macroglobulinemia) may cause manifestations of excess blood viscosity (as is the case for IgM antibodies in Waldenström macroglobulinemia) and/or precipitate within blood vessels when temperature drops (as in cryoglobulinaemia).
Other macroglobulins include alpha-2 macroglobulin, which is elevated in nephrotic syndrome, diabetes, severe burns, and other conditions, while a deficiency is associated with chronic obstructive pulmonary disease.
References[edit]
- ^ "Definition: macroglobulin from Online Medical Dictionary".
External links[edit]
- Macroglobulins at the US National Library of Medicine Medical Subject Headings (MeSH)
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Proteins: Globular proteins
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| Serum globulins |
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Alpha globulins
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serpins:
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- alpha-1 (Alpha 1-antichymotrypsin, Alpha 1-antitrypsin)
- alpha-2 (Alpha 2-antiplasmin)
- Antithrombin (Heparin cofactor II)
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carrier proteins:
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- alpha-1 (Transcortin)
- alpha-2 (Ceruloplasmin)
- Retinol binding protein
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other:
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- alpha-1 (Orosomucoid)
- alpha-2 (alpha-2-Macroglobulin, Haptoglobin)
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Beta globulins
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carrier proteins:
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- Sex hormone-binding globulin
- Transferrin
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other:
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- Angiostatin
- Hemopexin
- Beta-2 microglobulin
- Factor H
- Plasminogen
- Properdin
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Gamma globulin
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Other
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- Fibronectin (Fetal fibronectin)
- Macroglobulin/Microglobulin
- Transcobalamin
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| Other globulins |
- Beta-lactoglobulin
- Thyroglobulin
- Alpha-lactalbumin
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| Albumins |
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Egg white
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- Conalbumin
- Ovalbumin
- Avidin
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Serum albumin
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- Human serum albumin
- Bovine serum albumin
- Prealbumin
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Other
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- C-reactive protein
- Lactalbumin (Alpha-lactalbumin)
- Parvalbumin
- Ricin
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- see also disorders of globin and globulin proteins
- B proteins: BY STRUCTURE: membrane, globular (en, ca, an), fibrous
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UpToDate Contents
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English Journal
- Fibroblastic Synoviocytes Secrete Plasma Proteins Via α2 -Macroglobulins Serving as Intracellular and Extracellular Chaperones.
- Zhao KW1, Murray EJ2,3, Murray SS2,3,4.
- Journal of cellular biochemistry.J Cell Biochem.2015 Nov;116(11):2563-76. doi: 10.1002/jcb.25201.
- Changes in plasma protein levels in synovial fluid (SF) have been implicated in osteoarthritis and rheumatoid arthritis. It was previously thought that the presence of plasma proteins in SF reflected ultrafiltration or extravasation from the vasculature, possibly due to retraction of inflamed endoth
- PMID 25900303
- Modelling of macromolecular proteins in prophenoloxidase cascade through experimental and computational approaches.
- Sivakamavalli J1, Selvaraj C2, Singh SK3, Vaseeharan B4.
- Biotechnology and applied biochemistry.Biotechnol Appl Biochem.2015 Oct 15. doi: 10.1002/bab.1450. [Epub ahead of print]
- Prophenoloxidase (ProPO) cascade is a principle defence system in crustaceans, which consists of a variety of pattern recognition proteins (β- Glucan Binding Protein, Lipopolysaccharide and β-Glucan Binding Protein, β- Glucan Recognition Protein), proteases (serine protease) and protease inhibito
- PMID 26466758
- Mutational analysis of Kaposica reveals that bridging of MG2 and CUB domains of target protein is crucial for the cofactor activity of RCA proteins.
- Gautam AK1, Panse Y1, Ghosh P2, Reza MJ1, Mullick J3, Sahu A4.
- Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2015 Oct 13;112(41):12794-9. doi: 10.1073/pnas.1506449112. Epub 2015 Sep 29.
- The complement system has evolved to annul pathogens, but its improper regulation is linked with diseases. Efficient regulation of the system is primarily provided by a family of proteins termed regulators of complement activation (RCA). The knowledge of precise structural determinants of RCA protei
- PMID 26420870
Japanese Journal
- Quantification of horse plasma proteins altered by xylazine using the fluorogenic derivatization-liquid chromatography-tandem mass spectrometry
- A Case of Primary Macroglobulinemia Initially Presented as Sensorineural Hearing Loss
- 感音難聴を契機に発見された原発性マクログロブリン血症例
Related Links
- macroglobulin [mak″ro-glob´u-lin] a protein (globulin) of high molecular weight, in the range of 1,000,000; observed in the blood in a number of diseases. α 2-macroglobulin a plasma protein that inhibits a wide variety of proteolytic ...
- Macroglobulin definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it up now! Thesaurus Translate Puzzles & Games Word of the Day Blog Slideshows Apps by Dictionary Log In ...
★リンクテーブル★
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- 英
- macroglobulin
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- 関
- apoE receptor、apolipoprotein E receptor、LDL-receptor related protein 1
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マクログロブリン血症
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マクログロブリン血症
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マクログロブリン血症
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マクログロブリン血症