lymphokine activated killer cell

LAK細胞

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• 1. 進行黒色腫に対するインターロイキン2および実験的免疫学的アプローチinterleukin 2 and experimental immunotherapy approaches for advanced melanoma [show details]
  …maximum of 28 doses per course) either alone or in combination with lymphokine-activated killer (LAK) cells. Extended follow-up of 270 patients treated with high-dose IL-2 at the National Cancer Institute …
• 2. 造血細胞移植後の移植片対腫瘍効果の生物学biology of the graft versus tumor effect following hematopoietic cell transplantation [show details]
  …resulting in cells with enhanced anti-tumor cell activity (termed lymphokine activated killer [LAK] cells). However, since NK cells do not expand effectively ex vivo, it is difficult to obtain the numbers…
• 3. 生物学的製剤を用いた癌治療の神経学的合併症neurologic complications of cancer treatment with biologic agents [show details]
  …with IL-2. Administration of IL-2 directly into the tumor bed (with lymphokine-activated killer [LAK] cells) for the treatment of gliomas can cause significant cerebral edema, and neurotoxicity appears to…
• 4. 原発性筋層非浸潤性膀胱癌の治療treatment of primary non muscle invasive urothelial bladder cancer [show details]
  …increase the sensitivity of bladder tumor cells to BCG by activating lymphokine-activated killer (LAK) cells and antigen-presenting cells. Elevated urinary cytokine levels, including interleukin (IL)-1,…
• 5. 腎細胞癌の免疫療法immunotherapy of renal cell carcinoma [show details]

English Journal

• Ex vivo-expanded highly purified natural killer cells in combination with temozolomide induce antitumor effects in human glioblastoma cells in vitro.

• Tanaka Y, Nakazawa T, Nakamura M, Nishimura F, Matsuda R, Omoto K, Shida Y, Murakami T, Nakagawa I, Motoyama Y, Morita H, Tsujimura T, Nakase H.
• PloS one. 2019 ;14(3)e0212455.
• Glioblastoma is the leading malignant glioma with a poor prognosis. This study aimed to investigate the antitumor effects of natural killer cells in combination with temozolomide as the standard chemotherapeutic agent for glioblastoma. Using a simple, feeder-less, and chemically defined culture meth
• PMID 30840664

• Oxidative activation of type III CD38 by NADPH oxidase-derived hydrogen peroxide in Ca signaling.

• Park DR, Nam TS, Kim YW, Bae YS, Kim UH.
• FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019 Mar;33(3)3404-3419.
• Reactive oxygen species (ROS) derived from NADPH oxidase (Nox) has been shown to activate ADP-ribosyl cyclase (ARC), which produces the Ca mobilizing second messenger, cyclic ADP-ribose (cADPR). In the present study, we examined how ROS activates cluster of differentiation (CD)38, a mammalian protot
• PMID 30452880

• A Review of Immunotherapeutic Strategies in Canine Malignant Melanoma.

• Almela RM, Ansón A.
• Veterinary sciences. 2019 Feb;6(1).
• In dogs, melanomas are relatively common tumors and the most common form of oral malignancy. Biological behavior is highly variable, usually aggressive, and frequently metastatic, with reported survival times of three months for oral or mucosal melanomas in advanced disease stages. Classical clinica
• PMID 30759787

Japanese Journal

• Influence of transfusion of lymphokine-activated T killer cells on inflammatory responses in dogs after laparotomy

• MIE Keiichiro,TOMIHARI Mizuki,HOSHI Kiyotaka,NAKAMURA Takashi,YAMAGUCHI Tomohiro,MIYAHARA Kazuro,SHIMADA Terumasa
• The journal of veterinary medical science 78(4), 579-585, 2016-04
• NAID 40020843406

• Influence of transfusion of lymphokine-activated T killer cells on inflammatory responses in dogs after laparotomy

• MIE Keiichiro,TOMIHARI Mizuki,HOSHI Kiyotaka,NAKAMURA Takashi,YAMAGUCHI Tomohiro,MIYAHARA Kazuro,SHIMADA Terumasa
• Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ 78(4), 579-585, 2016
• … The influence of transfusion of lymphokine-activated T killer cells (T-LAK) on inflammatory responses was examined in dogs after laparotomy. … Plasma C-reactive protein (CRP) level, cell numbers of peripheral blood lymphocytes (PBLs) and T lymphocyte subsets (CD3⁺, CD4⁺ …
• NAID 130007331497

• 免疫細胞療法 (特集 大腸癌の最新治療 : 治癒に向けた最先端研究)

• 柴田 昌彦,権田 憲士,隈元 謙介 [他]
• 日本臨床 72(1), 42-48, 2014-01
• NAID 40019920508

Related Links

• Definition of lymphokine-activated killer cells - NCI Drug ...

Killer cell lymphocytes activated in the presence of interleukin-2 (IL-2). Lymphokine-activated killer cells (LAKs) are cytotoxic effector cells with an exceptionally wide target cell spectrum including normal and malignant ...

• Lymphokine-activated killer cell activity: Immunology Today

Leukocytes in blood and spleen can be activated by interleukin 2 (IL-2) to become cytotoxic to certain tumor cell lines in vitro. Recent evidence suggests that such lymphokine-activated killer (LAK) cells can bring about the regression ...

• Lymphokine-Activated Killer Cell - an overview | ScienceDirect ...

Changes in natural killer cell activity, 60, 61 lymphokine-activated killer cell activity, 60 interleukin-6, 62 and soluble tumor necrosis factor–alpha receptor 1 61 have all been reported with total sleep deprivation and sleep restriction. ...

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★リンクテーブル★

リンク元	「LAK細胞」
拡張検索	「lymphokine-activated killer cell」
関連記事	「kill」「activated」「activate」「killer」「cell」

「LAK細胞」

　　[★]

英

lymphokine activated killer cell, LAK cell

同

リンホカイン活性化キラー細胞 lymphokine-activated killer cell

関

NK細胞

• IL-2により活性化されたNK細胞を指す (SPU.65)　キラーT細胞も誘導される。
• CD16はNK細胞の活性化のマーカーとなる (SPU.65)

「lymphokine-activated killer cell」

　　[★]

• リンホカイン活性化キラー細胞、リンフォカイン活性化キラー細胞、LAK細胞

関

LAK cell

「kill」

　　[★]

• v.

• 殺す、死滅させる

関

killing

linux

option

9 KILL プロセスの強制終了

• ex.

kill -9 process_id

　 　 　 　 　 　 　 　 　 　 　 　 　 　 　

「activated」

　　[★]

• adj.

• 活性化の、活性化型の、賦活化の

関

activate、activated form、activation、turn on

　 　 　 　

「activate」

　　[★]

• v.

• 活性化する、賦活化する、賦活する

関

activated、activation、turn on

　 　 　 　 　

「killer」

　　[★]

• キラー、殺し屋

　 　 　

「cell」

　　[★] 細胞