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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/29 19:07:11」(JST)

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A hepatic lobule is a small division of the liver defined at the histological scale. It should not be confused with the anatomic lobes of the liver (caudate lobe, quadrate lobe, left lobe, and right lobe), or any of the functional lobe classification systems.

The two-dimensional microarchitecture of the liver can be viewed from multiple different perspectives:^[1]

Name	Shape	Model
classical lobule^[2]	hexagonal; divided into concentric centrilobular, midzonal, periportal parts	anatomical
portal lobule^[3]	triangular; centered on a portal triad	bile secretion
acinus ^[4]	elliptical or diamond-shaped; divided into zone I (periportal), zone II (transition zone), and zone III (pericentral)	blood flow and metabolic

The term "hepatic lobule", without qualification, typically refers to the classical lobule.

Zones

Oxygenation zones are numbered inside the diamond-shaped acinus (in red)

From a metabolic perspective, the functional unit is the hepatic acinus (terminal acinus), each of which is centered on the line connecting two portal triads and extends outwards to the two adjacent central veins. The periportal zone I is nearest to the entering vascular supply and receives the most oxygenated blood, making it least sensitive to ischemic injury while making it very susceptible to viral hepatitis. Conversely, the centrilobular zone III has the poorest oxygenation, and will be most affected during a time of ischemia.^[5]

Functionally, zone I hepatocytes are specialized for oxidative liver functions such as gluconeogenesis, β-oxidation of fatty acids and cholesterol synthesis, while zone III cells are more important for glycolysis, lipogenesis and cytochrome P-450-based drug detoxification.^[6] This specialization is reflected histologically; the detoxifying zone III cells have the highest concentration of CYP2E1 and thus are most sensitive to NAPQI production in acetaminophen toxicity.^[7] Other zonal injury patterns include zone I deposition of hemosiderin in hemochromatosis and zone II necrosis in yellow fever.^[6]

References

^ Cell and Tissue Structure at U. Va.
^ Histology image: 88_03 at the University of Oklahoma Health Sciences Center
^ Histology image: 88_09a at the University of Oklahoma Health Sciences Center
^ Histology image: 88_09b at the University of Oklahoma Health Sciences Center
^ B.R. Bacon, J.G. O'Grady, A.M. Di Bisceglie, J.R. Lake (2006). Comprehensive Clinical Hepatology. Elsevier Health Sciences. ISBN 0-323-03675-9.
^ ^a ^b E.R. Schiff, M.F. Sorrell, W.C. Maddrey, ed. (2007). Schiff's Diseases of the Liver, Tenth Edition. Lippincott William & Wilkins. ISBN 0-7817-6040-2.
^ M.J. Burns, S.L. Friedman, A.M. Larson (2009). "Acetaminophen (paracetamol) poisoning in adults: Pathophysiology, presentation, and diagnosis". In D.S. Basow. UpToDate. Waltham, MA: UpToDate.

External links

Histology image: 15401loa – Histology Learning System at Boston University
Histology at siumed.edu
Histology at okstate.edu
Histology at webmd.idv.tw.
UIUC Histology Subject 923

UpToDate Contents

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English Journal

[Effects of intrahepatic cholestasis on morphology of fetal lungs in pregnant rat].

Shi Y1, Qi HB.
Zhonghua fu chan ke za zhi.Zhonghua Fu Chan Ke Za Zhi.2010 Apr;45(4):283-6.
PMID 20646541

Japanese Journal

ブロイラー肝臓における脂肪蓄積の組織学的所見と肝臓脂質含量との関係

日本畜産学会報 58(4), 289-292, 1987
NAID 130000739506

「肝小葉」

Lobules of liver
	The structure of the liver’s functional units or lobules. Blood enters the lobules through branches of the portal vein and hepatic artery proper, then flows through sinusoids.
Details
Latin	lobuli hepatis
Identifiers
TA	A05.8.01.056
FMA	76488
	Anatomical terminology

　　[★]

英: lobule of liver (Z), hepatic lobules
ラ: lobuli hepatis
関: 肝臓

[1] Cell and Tissue Structure at U. Va.

[2] Histology image: 88_03 at the University of Oklahoma Health Sciences Center

[3] Histology image: 88_09a at the University of Oklahoma Health Sciences Center

[4] Histology image: 88_09b at the University of Oklahoma Health Sciences Center

[bacon-5] B.R. Bacon, J.G. O'Grady, A.M. Di Bisceglie, J.R. Lake (2006). Comprehensive Clinical Hepatology. Elsevier Health Sciences. ISBN 0-323-03675-9.

[schiff-6] E.R. Schiff, M.F. Sorrell, W.C. Maddrey, ed. (2007). Schiff's Diseases of the Liver, Tenth Edition. Lippincott William & Wilkins. ISBN 0-7817-6040-2.

[7] M.J. Burns, S.L. Friedman, A.M. Larson (2009). "Acetaminophen (paracetamol) poisoning in adults: Pathophysiology, presentation, and diagnosis". In D.S. Basow. UpToDate. Waltham, MA: UpToDate.

匿名

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案内

案内

lobuli hepatis