lipodystrophy

リポジストロフィー

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/05/10 21:54:47」(JST)

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Lipodystrophy
Classification and external resources
ICD-10	E88.1
ICD-9	272.6
DiseasesDB	30066
eMedicine	med/1307 med/3523
MeSH	D008060

Lipodystrophy is a medical condition characterized by abnormal or degenerative conditions of the body's adipose tissue. ("Lipo" is Greek for "fat" and "dystrophy" is Greek for "abnormal or degenerative condition".) A more specific term, lipoatrophy is used when describing the loss of fat from one area (usually the face). This condition is also characterized by a lack of circulating leptin which may lead to osteosclerosis.

Types

Lipodystrophy is be divided into the following types:

• Congential lipodystrophies

• Congenital generalized lipodystrophy (Beradinelli-Seip syndrome)
• Familial partial lipodystrophy

• Acquired lipodystrophy

• Acquired partial lipodystrophy (Barraquer-Simons syndrome)
• Acquired generalized lipodystrophy
• Centrifugal abdominal lipodystrophy (Lipodystrophia centrifugalis abdominalis infantilis)
• Lipoatrophia annularis (Ferreira-Marques lipoatrophia)
• Localized lipodystrophy
• HIV-associated lipodystrophy

Insulin injections

A lipodystrophy can be a lump or small dent in the skin that forms when a person keeps performing injections in the same spot. These types of lipodystrophies are harmless. People who want to avoid them can do so by changing (rotating) the places where they perform injections. For people with diabetes, using purified insulins may also help.

One of the side-effects of lipodystrophy is the rejection of the injected medication, the slowing down of the absorption of the medication, or trauma that can cause bleeding that, in turn, will reject the medication. In any of these scenarios, the dosage of the medication, such as insulin for diabetics, becomes impossible to gauge correctly and the treatment of the disease for which the medication is administered is impaired thereby allowing the medical condition to worsen.

In some cases, rotation of the injection sites may not be enough to prevent lipodystrophy.

Antiretroviral drugs

Lipodystrophies can be a possible side effect of antiretroviral drugs. Other lipodystrophies manifest as lipid redistribution; with excess, or lack of, fat in various regions of the body. These include, but are not limited to, having sunken cheeks and/or "humps" on the back or back of the neck (also referred to as buffalo hump) which also exhibits due to excess cortisol.

Hereditary forms

Lipodystrophy can be caused by metabolic abnormalities due to genetic issues. These are often characterized by insulin resistance and are associated with Metabolic Syndrome.

See also

• Keppen–Lubinsky Syndrome

References

External links

• DermAtlas 1847886158
• TheBody: The Lipoatrophy Resource Center

UpToDate Contents

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• 1. 脂肪異栄養症症候群 lipodystrophic syndromes
• 2. HIV関連リポジストロフィーの治療 treatment of hiv associated lipodystrophy
• 3. HIV関連リポジストロフィーの疫学、臨床症状、および診断 epidemiology clinical manifestations and diagnosis of hiv associated lipodystrophy
• 4. 脂肪織炎：認識および診断 panniculitis recognition and diagnosis
• 5. 黒色表皮腫 acanthosis nigricans

English Journal

• Regulation of lipin1 by nutritional status, adiponectin, sex and pituitary function in rat white adipose tissue.

• González CR, Novelle MG, Caminos JE, Vázquez MJ, Luque RM, López M, Nogueiras R, Diéguez C.SourceDepartment of Physiology, School of Medicine-Instituto de Investigaciones Sanitarias (IDIS), University of Santiago de Compostela, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela 15782, Spain.
• Physiology & behavior.Physiol Behav.2012 Feb 1;105(3):777-83. Epub 2011 Oct 25.
• Lipin1 is a member of the lipin protein family that plays an important role in the regulation of lipid metabolism. The endogenous role of lipin1 was demonstrated by the fact that mutations in lipin1 caused lipodystrophy and metabolic disorders. The aim of this study was to assess the influence of nu
• PMID 22051776

• Genetic polymorphisms in estrogen receptors and sexual dimorphism in fat redistribution in HIV-infected patients on HAART.

• Gasparotto AS, Sprinz E, Lazzaretti RK, Kuhmmer R, Silveira JM, Basso RP, Pinheiro CA, Silveira MF, Ribeiro JP, Mattevi VS.SourceaPrograma de Pós-graduação em Ciências da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre bHospital de Clínicas de Porto Alegre, Porto Alegre cHospital Universitário Dr Miguel Riet Correa Jr., Universidade Federal do Rio Grande, Rio Grande dServiço de Assistência Especializada em HIV/AIDS, Universidade Federal de Pelotas, Pelotas, Rio Grande do Sul, Brazil.
• AIDS (London, England).AIDS.2012 Jan 2;26(1):19-26.
• OBJECTIVE: : To investigate genetic single nucleotide polymorphisms (SNPs) in estrogen receptor-α (ERα) (ESR1, rs2234693, rs1801132, rs7757956 and rs2813544) and ERβ (ESR2, rs3020450, rs7154455 and rs4986938) genes and relate them to the adverse effects lipodystrophy, dyslipidemia and metabolic s
• PMID 22011627

• Delineating the role of alterations in lipid metabolism to the pathogenesis of inherited skeletal and cardiac muscle disorders: Thematic Review Series: Genetics of Human Lipid Diseases.

• Saini-Chohan HK, Mitchell RW, Vaz FM, Zelinski T, Hatch GM.SourceDepartment of Pharmacology and Therapeutics and Academic Medical Center, Amsterdam, The Netherlands.
• Journal of lipid research.J Lipid Res.2012 Jan;53(1):4-27. Epub 2011 Nov 7.
• As the specific composition of lipids is essential for the maintenance of membrane integrity, enzyme function, ion channels, and membrane receptors, an alteration in lipid composition or metabolism may be one of the crucial changes occurring during skeletal and cardiac myopathies. Although the inher
• PMID 22065858

Japanese Journal

• Polymorphisms of the ApoE (Apolipoprotein E) Gene and Their Influence on Dyslipidemia in HIV-1-Infected Individuals

• , , [他], , , , , ,
• Japanese Journal of Infectious Diseases 68(1), 5-12, 2015
• … The purpose of this retrospective case-control study was to investigate the frequency of Apolipoprotein E (ApoE) polymorphisms and their influence on antiretroviral therapy (ART)-induced lipodystrophy or dyslipidemia in HIV-infected Thai patients. … The clinical characteristics and frequencies of ApoE genotypes were compared between the case (moderate to severe lipodystrophy, n = 67) and control (absent to mild lipodystrophy, n = 18) groups. …
• NAID 130004757124

• 脂肪萎縮症とレプチン治療 (第5土曜特集 肥満の医学 : 臨床と研究の最先端) -- (トランスレーショナルリサーチ)

• 海老原 健
• 医学のあゆみ 250(9), 709-712, 2014-08-30
• NAID 40020171321

• 脂肪萎縮症におけるレプチン治療

• 海老原 健
• 内分泌・糖尿病・代謝内科 38(1), 75-80, 2014-01
• NAID 40019957770

Related Pictures

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★リンクテーブル★

リンク元	「リポジストロフィー」「fat atrophy」「脂肪萎縮症」
拡張検索	「congenital generalized lipodystrophy」「HIV lipodystrophy syndrome」「HIV-associated lipodystrophy syndrome」「congenital lipodystrophy」

「リポジストロフィー」

　　[★]

英

lipodystrophy

同

脂肪異栄養症、脂肪萎縮症？、リポジストロフィ

[show details]

脂肪異栄養症 : 約 17,500 件
脂肪萎縮症 : 約 25,800 件
リポジストロフィ : 約 728 件
リポジストロフィー : 約 416,000 件

概念

• 身体の脂肪組織の著しい減少を示す疾患

分類

• generalized lipodystrophy
• 部分的脂肪異栄養症 partial lipodystrophy：膜性増殖性糸球体腎炎(MPGN)のII型に合併することがある(PED.1250)

参考

• 写真

http://tabetainjya.com/archives/surprise/post_697/

• wikipedia

http://en.wikipedia.org/wiki/Lipodystrophy

• お医者になるのは、大変ですね:年老いて見える病の少女－脂肪異栄養症

http://oisha.livedoor.biz/archives/51428729.html

• wibio

http://www.weblio.jp/content/%E3%83%AA%E3%83%9D%E3%82%B8%E3%82%B9%E3%83%88%E3%83%AD%E3%83%95%E3%82%A3%E3%83%BC

「fat atrophy」

　　[★]

脂肪萎縮症、脂肪萎縮、脂肪組織萎縮、脂肪組織萎縮症

関

lipoatrophy、lipodystrophy

「脂肪萎縮症」

　　[★]

英

circumscribed lipoatrophy, lipodystrophy？

ラ

lipatrophia circumscripta

関

脂肪異栄養症？

「congenital generalized lipodystrophy」

　　[★] 先天性全身型リポジストロフィー、先天性全身性リポジストロフィー

「HIV lipodystrophy syndrome」

　　[★]

HIVリポジストロフィー症候群

関

HIV-associated lipodystrophy syndrome

「HIV-associated lipodystrophy syndrome」

　　[★]

HIV関連脂肪異栄養症症候群

関

HIV lipodystrophy syndrome

「congenital lipodystrophy」

　　[★] 先天性脂肪異栄養症、先天性リポジストロフィー