WordNet

a complex consisting of an organic base in association with hydrogen chloride

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/08/25 19:33:35」(JST)

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Levobunolol (AK-Beta, Liquifilm, Betegan) is a non-selective beta blocker. It is used topically to manage glaucoma.

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External links[edit source | edit]

Ishibashi T, Yokoi N, Kinoshita S (2003). "Comparison of the effects of topical levobunolol and timolol solution on the human ocular surface.". Cornea 22 (8): 709–15. doi:10.1097/00003226-200311000-00001. PMID 14576520.
Ogasawara H, Yoshida A, Fujio N, Konno S, Ishiko S (1999). "[Effect of topical levobunolol on retinal, optic nerve head, and choroidal circulation in normal volunteers]". Nippon Ganka Gakkai Zasshi 103 (7): 544–50. PMID 10443129.
Leung M, Grunwald J (1997). "Short-term effects of topical levobunolol on the human retinal circulation.". Eye 11 (3): 371–6. doi:10.1038/eye.1997.78. PMID 9373479.

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1. 原発性乳児緑内障 primary infantile glaucoma

English Journal

Intraocular pressure-lowering effect of oral paracetamol and its in vitro corneal penetration properties.

Mohamed N, Meyer D.SourceDivision of Ophthalmology, Faculty of Medicine and Health Sciences, University of Stellenbosch, Cape Town, South Africa.
Clinical ophthalmology (Auckland, N.Z.).Clin Ophthalmol.2013;7:219-27. doi: 10.2147/OPTH.S38473. Epub 2013 Jan 30.
BACKGROUND: Several studies have confirmed the ability of cannabinoids to reduce intraocular pressure. Experimental data recently demonstrated unequivocally that the analgesic effect of paracetamol is due to its indirect action on cannabinoid receptors. The question then arises as to whether paracet
PMID 23390358

Effects of anti-glaucoma drugs on resistive index of the medial long posterior ciliary artery using color Doppler imaging in Beagle dogs.

Choi H, Lee Y, Yeon S, Lee H, Lee H.SourceDepartment of Veterinary Medical Imaging, College of Veterinary Medicine, Chungnam National University, Daejeon 305-764, Korea.
Journal of veterinary science.J Vet Sci.2011 Mar;12(1):99-101.
Color Doppler imaging (CDI) was carried out to evaluate the effects of anti-glaucoma drugs on ophthalmic circulation using CDI-derived resistive index (RI) values. CDI was performed on nine Beagle dogs, and RI values were calculated for the medial long posterior ciliary artery before and after the a
PMID 21368570

Effects of topical 0.5% levobunolol alone or in association with 2% dorzolamide compared with a fixed combination of 0.5% timolol and 2% dorzolamide on intraocular pressure and heart rate in dogs without glaucoma.

Scardillo A, Pugliese M, De Majo M, Niutta PP, Pugliese A.SourceDepartment of Veterinary Public Health, Veterinary Medicine Faculty, University of Messina, Italy. scardale2002@yahoo.it
Veterinary therapeutics : research in applied veterinary medicine.Vet Ther.2010 Fall;11(3):E1-6.
The goal of glaucoma management is to reduce intraocular pressure (IOP) and maintain it at a level compatible with the health of the optic nerve. New therapies are constantly being sought. Topical instillation of levobunolol 0.5%, alone or with dorzolamide 2%, has a hypotensive effect on the IOP in
PMID 20960417

Japanese Journal

塩酸レボブノロールの点眼回数切り替えによる眼圧下降効果の検討 (特集第61回日本臨床眼科学会講演集(6))

永沢倫,菅野誠,土谷大仁朗他
臨床眼科 62(8), 1339-1341, 2008-08-00
NAID 40016218186

塩酸レボブノロール点眼液の点眼回数の切り替えによる比較

深水真,江連司,井上賢治,若倉雅登,井上治郎,富田剛司
日本眼科紀要 = Folia ophthalmologica Japonica 57(1), 39-43, 2006-01-28
NAID 10017994941

塩酸レボブノロール点眼液とラタノプロスト点眼液の併用による眼圧下降効果

原浩昭,白柏基宏,福地健郎,須田生英子,阿部春樹,山崎芳夫,木村泰朗,川端紀穂,大山晃弘,宮田博,園田日出男,今井晃
緑内障 = Journal of Japan Glaucoma Society 15(1), 63-67, 2005-09-05
NAID 10017292232

「レボブノロール」

Levobunolol
Systematic (IUPAC) name
	(S)-5-{[3-(tert-butylamino)-2-hydroxypropyl]oxy}-3,4-dihydronaphthalen-1(2H)-one
Clinical data
Trade names	Betagan
AHFS/Drugs.com	monograph
MedlinePlus	a686011
Pregnancy cat.	C
Legal status	℞-only (US)
Routes	Topical (eye drops)
Pharmacokinetic data
Half-life	20 hours
Identifiers
CAS number	47141-42-4
ATC code	S01ED03
PubChem	CID 39468
DrugBank	DB01210
ChemSpider	36089
UNII	G6317AOI7K
KEGG	D08115
ChEBI	CHEBI:6438
ChEMBL	CHEMBL1201237
Chemical data
Formula	C17H25NO3
Mol. mass	291.385 g/mol
	SMILES O=C2c1cccc(OC[C@@H](O)CNC(C)(C)C)c1CCC2;
	InChI InChI=1S/C17H25NO3/c1-17(2,3)18-10-12(19)11-21-16-9-5-6-13-14(16)7-4-8-15(13)20/h5-6,9,12,18-19H,4,7-8,10-11H2,1-3H3/t12-/m0/s1 ; Key:IXHBTMCLRNMKHZ-LBPRGKRZSA-N ;
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　　[★]

英: levobunolol
化: 塩酸レボブノロール levobunolol hydrochloride
商: ミロル
関: 眼科用剤

「levobunolol」

　　[★]

レボブノロール

関: levobunolol hydrochloride

「hydrochloride」

　　[★] 塩酸塩、ハイドロクロライド　

リンク元	「レボブノロール」
関連記事	「levobunolol」「hydrochloride」

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案内

levobunolol hydrochloride