レボブノロール
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- levobunolol hydrochloride
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/12/17 11:21:43」(JST)
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Levobunolol
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| Clinical data |
| Trade names |
Betagan |
| AHFS/Drugs.com |
Monograph |
| MedlinePlus |
a686011 |
Pregnancy
category |
|
Routes of
administration |
Topical (eye drops) |
| ATC code |
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| Legal status |
| Legal status |
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| Pharmacokinetic data |
| Biological half-life |
20 hours |
| Identifiers |
IUPAC name
- (S)-5-{[3-(tert-Butylamino)-2-hydroxypropyl]oxy}-3,4-dihydronaphthalen-1(2H)-one
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| CAS Number |
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| PubChem CID |
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| IUPHAR/BPS |
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| DrugBank |
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| ChemSpider |
|
| UNII |
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| KEGG |
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| ChEBI |
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| ChEMBL |
|
| Chemical and physical data |
| Formula |
C17H25NO3 |
| Molar mass |
291.385 g/mol |
| 3D model (JSmol) |
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SMILES
-
O=C2c1cccc(OC[C@@H](O)CNC(C)(C)C)c1CCC2
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InChI
-
InChI=1S/C17H25NO3/c1-17(2,3)18-10-12(19)11-21-16-9-5-6-13-14(16)7-4-8-15(13)20/h5-6,9,12,18-19H,4,7-8,10-11H2,1-3H3/t12-/m0/s1 Y
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Key:IXHBTMCLRNMKHZ-LBPRGKRZSA-N Y
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| NY (what is this?) (verify) |
Levobunolol (AK-Beta, Liquifilm, Betegan) is a non-selective beta blocker. It is used topically to manage glaucoma.
References
- Ishibashi T, Yokoi N, Kinoshita S (2003). "Comparison of the effects of topical levobunolol and timolol solution on the human ocular surface". Cornea. 22 (8): 709–15. doi:10.1097/00003226-200311000-00001. PMID 14576520.
- Ogasawara H, Yoshida A, Fujio N, Konno S, Ishiko S (1999). "[Effect of topical levobunolol on retinal, optic nerve head, and choroidal circulation in normal volunteers]". Nippon Ganka Gakkai Zasshi. 103 (7): 544–50. PMID 10443129.
- Leung M, Grunwald J (1997). "Short-term effects of topical levobunolol on the human retinal circulation". Eye. 11 (3): 371–6. doi:10.1038/eye.1997.78. PMID 9373479.
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Drugs used for glaucoma preparations and miosis (S01E)
|
| Sympathomimetics |
- Apraclonidine
- Brimonidine (+timolol)
- Clonidine
- Dipivefrine
- Epinephrine
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| Parasympathomimetics |
| muscarinic |
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| muscarinic/nicotinic |
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| acetylcholinesterase inhibitors |
- Demecarium
- Ecothiopate
- Stigmine (Fluostigmine
- Neostigmine
- Physostigmine)
- Paraoxon
|
|
Carbonic anhydrase inhibitors/
(sulfonamides) |
- Acetazolamide
- Brinzolamide (+timolol)
- Diclofenamide
- Dorzolamide (+timolol)
- Methazolamide
|
| Beta blocking agents |
- Befunolol
- Betaxolol
- Carteolol
- Levobunolol
- Metipranolol
- Timolol
- Mepindolol
|
| Prostaglandin analogues (F2α) |
- Bimatoprost (+timolol)
- Latanoprost (+timolol)
- Tafluprost
- Travoprost (+timolol)
- Unoprostone
|
| Other agents |
- Dapiprazole
- Guanethidine
- Ripasudil
|
|
Adrenergic receptor modulators
|
| α1 |
- Agonists: 6-FNE
- Amidephrine
- Anisodine
- Buspirone
- Cirazoline
- Corbadrine
- Desglymidodrine
- Dexisometheptene
- Dipivefrine
- Dopamine
- Droxidopa (L-DOPS)
- Ephedrine
- Epinephrine
- Etilefrine
- Etilevodopa
- Ethylnorepinephrine
- Indanidine
- Isometheptene
- L-DOPA (levodopa)
- L-Phenylalanine
- L-Tyrosine
- Melevodopa
- Metaraminol
- Methoxamine
- Methyldopa
- Midodrine
- Naphazoline
- Norepinephrine
- Octopamine (drug)
- Oxymetazoline
- Phenylephrine
- Phenylpropanolamine
- Pseudoephedrine
- Synephrine
- Tetryzoline
- Tiamenidine
- XP21279
- Xylometazoline
- Antagonists: Abanoquil
- Adimolol
- Ajmalicine
- Alfuzosin
- Amosulalol
- Anisodamine
- Arotinolol
- Atiprosin
- Atypical antipsychotics (e.g., brexpiprazole, clozapine, olanzapine, quetiapine, risperidone)
- Benoxathian
- Buflomedil
- Bunazosin
- Carvedilol
- Corynanthine
- Dapiprazole
- Domesticine
- Doxazosin
- Ergolines (e.g., ergotamine, dihydroergotamine, lisuride, terguride)
- Etoperidone
- Eugenodilol
- Fenspiride
- Hydroxyzine
- Indoramin
- Ketanserin
- L-765,314
- Labetalol
- mCPP
- Mepiprazole
- Metazosin
- Monatepil
- Moxisylyte
- Naftopidil
- Nantenine
- Neldazosin
- Niaprazine
- Nicergoline
- Niguldipine
- Pardoprunox
- Pelanserin
- Perlapine
- Phendioxan
- Phenoxybenzamine
- Phentolamine
- Phenylpiperazine antidepressants (e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione)
- Piperoxan
- Prazosin
- Quinazosin
- Quinidine
- Ritanserin
- Silodosin
- Spiperone
- Talipexole
- Tamsulosin
- Terazosin
- Tiodazosin
- Tolazoline
- Tetracyclic antidepressants (e.g., amoxapine, maprotiline, mianserin)
- Tricyclic antidepressants (e.g., amitriptyline, clomipramine, doxepin, imipramine, trimipramine)
- Trimazosin
- Typical antipsychotics (e.g., chlorpromazine, fluphenazine, loxapine, thioridazine)
- Urapidil
- WB-4101
- Zolertine
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| α2 |
- Agonists: (R)-3-Nitrobiphenyline
- 4-NEMD
- 6-FNE
- Amitraz
- Apraclonidine
- Brimonidine
- Cannabivarin
- Clonidine
- Corbadrine
- Detomidine
- Dexmedetomidine
- Dihydroergotamine
- Dipivefrine
- Dopamine
- Droxidopa (L-DOPS)
- Etilevodopa
- Ephedrine
- Ergotamine
- Epinephrine
- Etilefrine
- Ethylnorepinephrine
- Guanabenz
- Guanfacine
- Guanoxabenz
- L-DOPA (levodopa)
- L-Phenylalanine
- L-Tyrosine
- Lofexidine
- Medetomidine
- Melevodopa
- Methyldopa
- Mivazerol
- Naphazoline
- Norepinephrine
- Oxymetazoline
- Phenylpropanolamine
- Piperoxan
- Pseudoephedrine
- Rezatomidine
- Rilmenidine
- Romifidine
- Talipexole
- Tasipimidine
- Tetrahydrozoline
- Tiamenidine
- Tizanidine
- Tolonidine
- Urapidil
- Vatinoxan
- XP21279
- Xylazine
- Xylometazoline
- Antagonists: 1-PP
- Adimolol
- Amesergide
- Aptazapine
- Atipamezole
- Atypical antipsychotics (e.g., asenapine, brexpiprazole, clozapine, lurasidone, paliperidone, quetiapine, risperidone, zotepine)
- Azapirones (e.g., buspirone, gepirone, ipsapirone, tandospirone)
- BRL-44408
- Buflomedil
- Cirazoline
- Efaroxan
- Esmirtazapine
- Fenmetozole
- Fluparoxan
- Idazoxan
- mCPP
- Mianserin
- Mirtazapine
- NAN-190
- Olanzapine
- Pardoprunox
- Phentolamine
- Phenoxybenzamine
- Piperoxan
- Piribedil
- Rauwolscine
- Rotigotine
- SB-269970
- Setiptiline
- Spiroxatrine
- Sunepitron
- Tolazoline
- Typical antipsychotics (e.g., chlorpromazine, fluphenazine, loxapine, thioridazine)
- Yohimbine
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| β |
|
- See also: Receptor/signaling modulators
- Dopaminergics
- Serotonergics
- Monoamine reuptake inhibitors
- Monoamine releasing agents
- Monoamine metabolism modulators
- Monoamine neurotoxins
|
UpToDate Contents
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English Journal
- Ocular Metabolism of Levobunolol: Historic and Emerging Metabolic Pathways.
- Argikar UA1, Dumouchel JL2, Dunne CE2, Saran C2, Cirello AL2, Gunduz M2.
- Drug metabolism and disposition: the biological fate of chemicals.Drug Metab Dispos.2016 Aug;44(8):1304-12. doi: 10.1124/dmd.116.070458. Epub 2016 May 17.
- Although ocular transport and delivery have been well studied, metabolism in the eye is not well documented, even for clinically available medications such as levobunolol, a potent and nonselective β-adrenergic receptor antagonist. Recently, we reported an in vitro methodology that could be used to
- PMID 27190057
- Comparative Effectiveness of First-Line Medications for Primary Open-Angle Glaucoma: A Systematic Review and Network Meta-analysis.
- Li T1, Lindsley K2, Rouse B3, Hong H4, Shi Q3, Friedman DS5, Wormald R6, Dickersin K2.
- Ophthalmology.Ophthalmology.2016 Jan;123(1):129-40. doi: 10.1016/j.ophtha.2015.09.005. Epub 2015 Oct 31.
- TOPIC: Primary open-angle glaucoma (POAG) is a highly prevalent condition worldwide and the most common cause of irreversible sight loss. The objective is to assess the comparative effectiveness of first-line medical treatments in patients with POAG or ocular hypertension through a systematic review
- PMID 26526633
- Allergic contact dermatitis caused by timolol with cross-sensitivity to levobunolol.
- Horcajada-Reales C1, Rodríguez-Soria VJ1, Suárez-Fernández R1.
- Contact dermatitis.Contact Dermatitis.2015 Dec;73(6):368-9. doi: 10.1111/cod.12448. Epub 2015 Jul 31.
- PMID 26227808
Japanese Journal
- 正常眼圧緑内障患者におけるレボブノロール点眼5年間投与の効果
- ラタノプロスト点眼薬へのレボブノロール点眼追加療法
- 森山 涼,野口 圭,河本 ひろ美,塩川 美菜子,井上 賢治,若倉 雅登,富田 剛司
- 緑内障 : 日本緑内障学会雑誌 : journal of Japan Glaucoma Society 20(1), 64-66, 2010-12-27
- NAID 10027747688
- ラタノプロスト点眼薬へのレボブノロール点眼追加療法
- 森山 涼,野口 圭,河本 ひろ美 [他],塩川 美菜子,井上 賢治,若倉 雅登,富田 剛司
- あたらしい眼科 = Journal of the eye 27(8), 1112-1114, 2010-08-30
- NAID 10028245636
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