WordNet

matter that remains after something has been removed
a white crystalline amino acid occurring in proteins that is essential for nutrition; obtained by the hydrolysis of most dietary proteins

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Identifying a C-terminal ATP binding sites-based novel Hsp90-Inhibitor in silico: A plausible therapeutic approach in Alzheimer's disease.

Khalid S1, Paul S2.
Medical hypotheses.Med Hypotheses.2014 Jul;83(1):39-46. doi: 10.1016/j.mehy.2014.04.013. Epub 2014 Apr 13.
BACKGROUND: Alzheimer's disease (AD) is a progressive brain disorder, which gradually and irreversibly destroys the intellectual and cognitive abilities of the brain. Heat shock protein 90 (Hsp90α) is a molecular chaperone which was found to regulate the function of number of client proteins includ
PMID 24785461

N-terminal region is responsible for chemotaxis-inducing activity of flounder IL-8.

Kurata O1, Wada S2, Matsuyama T3, Sakai T4, Takano T5.
Fish & shellfish immunology.Fish Shellfish Immunol.2014 Jun;38(2):361-6. doi: 10.1016/j.fsi.2014.04.006. Epub 2014 Apr 18.
The objective of this study was to locate the functional region responsible for the chemotaxis-inducing activity of flounder interleukin 8 (IL-8), which lacks the glutamic acid-leucine-arginine (ELR) motif essential for the induction of neutrophil migration by mammalian IL-8. Using a human cell line
PMID 24751922

Synthesis of poly(alkenoic acid) with L-leucine residue and methacrylate photopolymerizable groups useful in formulating dental restorative materials.

Buruiana T1, Nechifor M, Melinte V, Podasca V, Buruiana EC.
Journal of biomaterials science. Polymer edition.J Biomater Sci Polym Ed.2014 Jun;25(8):749-65. doi: 10.1080/09205063.2014.905029. Epub 2014 Apr 7.
To develop resin-modified glass ionomer materials, we synthesized methacrylate-functionalized acrylic copolymer (PAlk-LeuM) derived from acrylic acid, itaconic acid and N-acryloyl-L-leucine using (N-methacryloyloxyethylcarbamoyl-N'-4-hydroxybutyl) urea as the modifying agent. The spectroscopic (prot
PMID 24701975

Flecainide Provocation Reveals Concealed Brugada Syndrome in a Long QT Syndrome Family With a Novel L1786Q Mutation in SCN5A

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Circulation Journal 78(5), 1136-1143, 2014
… Methods and Results: In a Danish family suffering from long QT syndrome, a novel missense mutation in SCN5A, changing a leucine residue into a glutamine residue at position 1786 (L1786Q), was found to be present in heterozygous form co-segregating with prolonged QT interval. …
NAID 130003391075

Mutation for Nonsyndromic Mental Retardation in the trans-2-Enoyl-CoA Reductase TER Gene Involved in Fatty Acid Elongation Impairs the Enzyme Activity and Stability, Leading to Change in Sphingolipid Profile

Abe Kensuke,Ohno Yusuke,Sassa Takayuki,Taguchi Ryo,Caliskan Minal,Ober Carole,Kihara Akio
Journal of biological chemistry 288(51), 36741-36749, 2013-12-20
… This mutation substitutes a leucine for a proline residue at amino acid 182 in the TER enzyme. …
NAID 120005385316

Compound Heterozygous Mutations in SLC30A2/ZnT2 Results in Low Milk Zinc Concentrations: A Novel Mechanism for Zinc Deficiency in a Breast-Fed Infant.

Itsumura Naoya,Inamo Yasuji,Okazaki Fumiko,Teranishi Fumie,Narita Hiroshi,Kambe Taiho,Kodama Hiroko
PloS one 8(5), 2013-05-31
… a T to C transition (c.454T>C) at exon 4, which substitutes a tryptophan residue with an arginine residue (W152R), and a C to T transition (c.887C>T) at exon 7, which substitutes a serine residue with a leucine residue (S296L). …
NAID 120005289848