WordNet

with the wind abaft the beam; "a ship sailing large"
a garment size for a large person
above average in size or number or quantity or magnitude or extent; "a large city"; "set out for the big city"; "a large sum"; "a big (or large) barn"; "a large family"; "big businesses"; "a big expenditure"; "a large number of newspapers"; "a big group of scientists"; "large areas of the world" (同)big
at a distance, wide of something (as of a mark)
fairly large or important in effect; influential; "played a large role in the negotiations"
having broad power and range and scope; "taking the large view"; "a large effect"; "a large sympathy"
an abnormal increase in the number of lymphocytes in the circulating blood

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Refining the diagnosis of T-cell large granular lymphocytic leukemia by combining distinct patterns of antigen expression with T-cell clonality studies.

Ohgami RS, Ohgami JK, Pereira IT, Gitana G, Zehnder JL, Arber DA.SourceDepartment of Pathology, Stanford University Medical Center, Stanford, CA, USA.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K.Leukemia.2011 Sep;25(9):1439-43. doi: 10.1038/leu.2011.107. Epub 2011 May 27.
T-cell large granular lymphocytic (LGL) leukemia is a complex diagnosis, requiring persistent clonal expansions of LGLs, and cytopenias. Often the diagnosis is unclear as non-clonal expansions of LGLs commonly occur in reactive conditions. To better understand T-LGL leukemia, we performed a comprehe
PMID 21617700

Clinical, morphologic, immunophenotypic, and molecular cytogenetic assessment of CD4-/CD8-γδ T-cell large granular lymphocytic leukemia.

Chen YH, Chadburn A, Evens AM, Winter JN, Gordon LI, Chenn A, Goolsby C, Peterson L.SourceDept of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
American journal of clinical pathology.Am J Clin Pathol.2011 Aug;136(2):289-99.
γδ T-cell large granular lymphocytic (T-LGL) leukemia of the CD4-/CD8- subtype is rare, and data are limited in the literature. This study evaluated the clinical, morphologic, immunophenotypic, and molecular cytogenetic features of 7 cases of CD4-/CD8- γδ T-LGL leukemia. Although this variant sh
PMID 21757603

Clinical features of dasatinib-induced large granular lymphocytosis and pleural effusion

NAGATA Yasunobu,OHASHI Kazuteru,FUKUDA Shiomi,KAMATA Noriko,AKIYAMA Hideki,SAKAMAKI Hisashi
International journal of hematology 91(5), 799-807, 2010-06-15
NAID 10026511167

Flow cytometric analysis of skin blister fluid induced by mosquito bites in a patient with chronic active Epstein-Barr virus infection

WADA Taizo,YOKOYAMA Tadafumi,NAKAGAWA Hiroyasu,ASAI Erika,TOGA Akiko,SAKAKIBARA Yasuhisa,SHIBATA Fumie,TONE Yumi,SHIMIZU Masaki,TOMA Tomoko,YACHIE Akihiro
International journal of hematology 90(5), 611-615, 2009-12-15
… NK cell-type infection (NK-CAEBV) is characterized by large granular lymphocytosis, high IgE levels and unusual reactions to mosquito bites, including severe local skin reactions, fever and liver dysfunction. …
NAID 10026110032