大細胞型リンパ腫、大細胞リンパ腫
- 関
- diffuse histiocytic lymphoma、diffuse large B-cell lymphoma、diffuse large-cell lymphoma、histiocytic lymphoma
WordNet
- with the wind abaft the beam; "a ship sailing large"
- a garment size for a large person
- above average in size or number or quantity or magnitude or extent; "a large city"; "set out for the big city"; "a large sum"; "a big (or large) barn"; "a large family"; "big businesses"; "a big expenditure"; "a large number of newspapers"; "a big group of scientists"; "large areas of the world" (同)big
- at a distance, wide of something (as of a mark)
- fairly large or important in effect; influential; "played a large role in the negotiations"
- having broad power and range and scope; "taking the large view"; "a large effect"; "a large sympathy"
- small room in which a monk or nun lives (同)cubicle
- a device that delivers an electric current as the result of a chemical reaction (同)electric cell
- a room where a prisoner is kept (同)jail cell, prison cell
- (biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
- any small compartment; "the cells of a honeycomb"
- a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
- a neoplasm of lymph tissue that is usually malignant; one of the four major types of cancer
PrepTutorEJDIC
- (同じ種類のものと比較して,形・体積・数量などが)『大きい』,多い,広い / (考えなどが)広範囲な,幅の広い,寛大な / 大きく / 自慢して,誇大に
- (刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/02 12:32:43」(JST)
[Wiki en表示]
| Large-cell lymphoma |
|
Micrograph of a primary mediastinal large B-cell lymphoma, a type of large-cell lymphoma. H&E stain.
|
| Classification and external resources |
| ICD-9-CM |
200.7 |
| MeSH |
D016403 |
One classification system for lymphomas divides the diseases according to the size of the white blood cells that has turned cancerous. The large-cell lymphomas have large cells. A large cell, in this context, has a diameter of 17 to 20 µm.[1] Other groups of lymphomas in this system are the small-cell lymphomas and mixed-cell lymphomas.
Types
B cell
Diffuse large B-cell lymphoma is the most common of the large-cell lymphomas. MeSH now classifies the phrase "large-cell lymphoma" under "Diffuse large B cell lymphoma".[2]
Many other B-cell lymphomas feature large cells:
- Angiocentric lymphoma
- Burkitt’s lymphoma
- Follicular large-cell lymphoma
- Immunoblastic lymphoma
- Intravascular large-cell lymphoma
- Primary mediastinal B-cell lymphoma
- T-cell–rich B-cell lymphoma
- Primary splenic lymphoma (rare)
- Primary central nervous system lymphomas, which are often diffuse large-B-cell lymphomas
Activated B-Cell Diffuse Large B-Cell Lymphoma, or ABC-DLBCL, is believed to be caused by aberrant activation of a critical intracellular pathway. This intracellular signaling pathway involved in B-cell activation and proliferation stays constantly activated, driving lymphocytes to proliferate continuously. The inhibition of this pathway can be induced by a drug known as NEMO Binding Domain, or NBD, a peptide causing increased cell death of malignant lymphocytes.
T cell
Less commonly, a large-cell lymphoma may feature T cells. Anaplastic large-cell lymphoma is an example of a large-cell lymphoma that involves T cells. Of the large-cell T-cell lymphomas, it has the best prognosis.[citation needed]
References
- ^ Turgeon, Mary Louise (2005). Clinical hematology: theory and procedures. Hagerstown, MD: Lippincott Williams & Wilkins. p. 221. ISBN 0-7817-5007-5.
- ^ Large cell lymphoma at the US National Library of Medicine Medical Subject Headings (MeSH)
|
Hematological malignancy/leukemia histology (ICD-O 9590–9989, C81–C96, 200–208)
Lymphoid/Lymphoproliferative, Lymphomas/Lymphoid leukemias (9590–9739, 9800–9839)
|
|
B cell
(lymphoma,
leukemia)
(most CD19
|
By development/
marker |
| TdT+ |
- ALL (Precursor B acute lymphoblastic leukemia/lymphoma)
|
|
| CD5+ |
- mantle zone (Mantle cell)
|
|
| CD22+ |
- Prolymphocytic
- CD11c+ (Hairy cell leukemia)
|
|
| CD79a+ |
- germinal center/follicular B cell (Follicular
- Burkitt's
- GCB DLBCL
- Primary cutaneous follicular lymphoma)
- marginal zone/marginal-zone B cell (Splenic marginal zone
- MALT
- Nodal marginal zone
- Primary cutaneous marginal zone lymphoma)
|
|
| RS (CD15+, CD30+) |
- Classic Hodgkin's lymphoma (Nodular sclerosis)
- CD20+ (Nodular lymphocyte predominant Hodgkin's lymphoma)
|
|
PCDs/PP
(CD38+/CD138+) |
- see immunoproliferative immunoglobulin disorders
|
|
|
| By infection |
- KSHV (Primary effusion)
- EBV (Lymphomatoid granulomatosis
- Post-transplant lymphoproliferative disorder)
- HIV (AIDS-related lymphoma)
- Helicobacter pylori (MALT lymphoma)
|
|
| Cutaneous |
- Diffuse large B-cell lymphoma
- Intravascular large B-cell lymphoma
- Primary cutaneous marginal zone lymphoma
- Primary cutaneous immunocytoma
- Plasmacytoma
- Plasmacytosis
- Primary cutaneous follicular lymphoma
|
|
|
| T/NK |
T cell
(lymphoma,
leukemia)
(most CD3
|
By development/
marker |
- TdT+: ALL (Precursor T acute lymphoblastic leukemia/lymphoma)
- prolymphocyte (Prolymphocytic)
- CD30+ (Anaplastic large-cell lymphoma
- Lymphomatoid papulosis type A)
|
|
| Cutaneous |
| MF+variants |
- indolent: Mycosis fungoides
- Pagetoid reticulosis
- Granulomatous slack skin
aggressive: Sézary disease
- Adult T-cell leukemia/lymphoma
|
|
| Non-MF |
- CD30-: Non-mycosis fungoides CD30− cutaneous large T-cell lymphoma
- Pleomorphic T-cell lymphoma
- Lymphomatoid papulosis type B
- CD30+: CD30+ cutaneous T-cell lymphoma
- Secondary cutaneous CD30+ large cell lymphoma
- Lymphomatoid papulosis type A
|
|
|
| Other peripheral |
- Hepatosplenic
- Angioimmunoblastic
- Enteropathy-associated T-cell lymphoma
- Peripheral T-cell lymphoma-Not-Otherwise-Specified (Lennert lymphoma)
- Subcutaneous T-cell lymphoma
|
|
| By infection |
- HTLV-1 (Adult T-cell leukemia/lymphoma)
|
|
|
NK cell/
(most CD56) |
- Aggressive NK-cell leukemia
- Blastic NK cell lymphoma
|
|
| T or NK |
- EBV (Extranodal NK-T-cell lymphoma/Angiocentric lymphoma)
- Large granular lymphocytic leukemia
|
|
|
| Lymphoid+myeloid |
- Acute biphenotypic leukaemia
|
|
| Lymphocytosis |
- Lymphoproliferative disorders (X-linked lymphoproliferative disease
- Autoimmune lymphoproliferative syndrome)
- Leukemoid reaction
- Diffuse infiltrative lymphocytosis syndrome
|
|
|
| Cutaneous lymphoid hyperplasia |
- Cutaneous lymphoid hyperplasia
- with bandlike and perivascular patterns
- with nodular pattern
- Jessner lymphocytic infiltrate of the skin
|
|
|
Index of the immune system
|
|
| Description |
- Physiology
- cells
- autoantigens
- autoantibodies
- complement
- surface antigens
- IG receptors
|
|
| Disease |
- Allergies
- Immunodeficiency
- Immunoproliferative immunoglobulin disorders
- Hypersensitivity and autoimmune disorders
- Neoplasms and cancer
|
|
| Treatment |
- Procedures
- Drugs
- antihistamines
- immunostimulants
- immunosuppressants
- monoclonal antibodies
|
|
|
UpToDate Contents
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English Journal
- Frequency of surveillance computed tomography in non-Hodgkin lymphoma and the risk of secondary primary malignancies: A nationwide population-based study.
- Chien SH1, Liu CJ1,2,3, Hu YW2,3,4, Hong YC2,5, Teng CJ2,6, Yeh CM2, Chiou TJ2,7, Gau JP1,2, Tzeng CH1,2.
- International journal of cancer. Journal international du cancer.Int J Cancer.2015 Aug 1;137(3):658-65. doi: 10.1002/ijc.29433. Epub 2015 Jan 29.
- With increasing usage of computed tomography (CT) for lymphoma patients receiving curative-intent treatment, development of secondary primary malignancy (SPM) related to radiation from CT scans becomes an emerging issue in these long-term survivors. We conducted a nationwide population-based study a
- PMID 25630766
- KSHV-associated multicentric Castleman disease: A tangle of different entities requiring multitarget treatment strategies.
- Carbone A1, De Paoli P2, Gloghini A3, Vaccher E4.
- International journal of cancer. Journal international du cancer.Int J Cancer.2015 Jul 15;137(2):251-61. doi: 10.1002/ijc.28923. Epub 2014 May 5.
- Multicentric Castleman Disease (MCD) is a lymphoproliferative disorder presenting with heterogeneous pathological and clinical features. It comprises disease entities with a complex aetiology and overlapping pathogenesis. MCD can be found in association with HIV infection, plasma-cell dyscrasias, Ka
- PMID 24771491
- Trends in cancer diagnoses and survival among persons with AIDS in a high HIV prevalence urban area.
- Castel AD1, Young H, Akiwumi AM, Vargas A, Rogers K, West T, Levine PH.
- AIDS care.AIDS Care.2015 Jul;27(7):860-9. doi: 10.1080/09540121.2015.1011074. Epub 2015 Feb 25.
- Washington, DC (DC), has among the highest AIDS prevalence and cancer incidence in the USA. This study compared cancer diagnoses and survival among AIDS cases with AIDS-defining cancers (ADCs) to those with non-AIDS-defining cancers (NADCs) in DC from 1996 to 2006. Survival by cancer type and time p
- PMID 25714364
Japanese Journal
- 藤井 のり子,長谷 哲男,谷 守
- Skin Cancer 28(1), 98-102, 2013
- … Mycosis fungoides（MF）やそのlarge cell transformationとするには，Pautrier微小膿瘍やmycosis細胞はみられず，真皮浸潤細胞は小型リンパ球，異型大型細胞，組織球など多彩で，免疫組織化学も多彩。 … Cutaneous anaplastic large cell lymphomaとするにはCD30の陽性率が低く，lymphomatoid papulosisは臨床像が当てはまらなかった。 …
- NAID 130003378176
- 遠心性環状紅斑を伴った原発性皮膚未分化大細胞リンパ腫の1例
- 横井 郁美,小浦 綾子,石川 絵美子,宗廣 明日香,森上 純子,今滝 修,窪田 泰夫
- Skin Cancer 28(1), 79-83, 2013
- 84歳，女性。初診の2年前に発症した躯幹の遠心性環状紅斑と，初診6ヵ月より出現した径6cmの右腋窩腫瘤を主訴に2011年11月10日に来院した。腫瘤の組織検査では，異型リンパ球が真皮から皮下組織にかけて密に浸潤し，腫瘍細胞周囲には，好酸球と組織球を混じた激しい炎症細胞浸潤を伴っていた。異型リンパ球は免疫組織学的にCD30，CD3，CD45RO，TIA-1，Granzyme Bに陽性，CD20，CD …
- NAID 130003378172
- Histiocytic Sarcoma : An Updated Literature Review Based on the 2008 WHO Classification
- Takahashi Emiko,Nakamura Shigeo
- Journal of Clinical and Experimental Hematopathology 53(1), 1-8, 2013
- … The vast majority of previously reported HSs are now generally recognized to be misdiagnosed examples of non-Hodgkin lymphomas, predominantly diffuse large B-cell lymphoma or anaplastic large cell lymphoma. … (<I>IG</I>) or <I>T</I><I>-cell receptor</I> …
- NAID 130003366781
Related Links
- Information and resources on large cell lymphoma, from type to diagnosing and more ... Large Cell Lymphoma (LCL) is typically an aggressive (fast growing) cancer of either the B cell or T cell type. They are one of the most common ...
- LRF is the largest non-profit organization in the nation devoted exclusively to funding innovative lymphoma research and providing people with lymphoma and healthcare professionals with up-to-date information about this type of ...
★リンクテーブル★
[★]
- 英
- large-cell lymphoma
- 関
- びまん性大細胞型リンパ腫、組織球性リンパ腫、大細胞型リンパ腫、びまん性組織球性リンパ腫
[★]
びまん性組織球性リンパ腫
- 関
- diffuse large B-cell lymphoma、diffuse large-cell lymphoma、histiocytic lymphoma、large-cell lymphoma
[★]
組織球性リンパ腫
- 関
- diffuse histiocytic lymphoma、diffuse large B-cell lymphoma、diffuse large-cell lymphoma、large-cell lymphoma
[★]
- 英
- large-cell lymphoma
- 関
- 大細胞リンパ腫
[★]
びまん性大細胞型リンパ腫、びまん性大細胞性リンパ腫、びまん性大細胞リンパ腫
- 関
- diffuse histiocytic lymphoma、diffuse large B-cell lymphoma、DLBCL、DLCL、histiocytic lymphoma、large-cell lymphoma
[★]
大細胞型濾胞性リンパ腫、濾胞性大細胞型リンパ腫、濾胞性大細胞リンパ腫
- 関
- follicular lymphoma、follicular mixed-cell lymphoma、follicular small cleaved-cell lymphoma、nodular lymphoma
[★]
Ki-1大細胞型リンパ腫、Ki-1リンパ腫
- 関
- anaplastic large-cell lymphoma、Ki-1 lymphoma
[★]
未分化大細胞リンパ腫
[★]
- 関
- great、massive、sizable
[★]
細胞