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1. 肥満細胞：増殖・分化、識別、および生理学的役割mast cells development identification and physiologic roles [show details]
… kit ligand (KL) or steel factor . The surface receptor for SCF, the receptor tyrosine kinase kit (CD117) generated from the gene KIT, is expressed by hematopoietic stem cells and is maintained during myeloid …
2. 肥満細胞症（皮膚および全身性）：疫学、病因、および臨床症状mastocytosis cutaneous and systemic epidemiology pathogenesis and clinical manifestations [show details]
…neoplasm. The molecular pathogenesis of mastocytosis is incompletely understood. Stem cell factor (SCF), also called kit ligand, is a growth factor that is essential for normal development and expansion of …
3. 骨髄造血の制御regulation of myelopoiesis [show details]
… populations SCF also plays an important role in melanocyte growth and development, which is reflected in the coat color effects of mutations in SCF or its receptor, Kit . Mice defective in either SCF (Sl mice) …
4. 肥満細胞症：概要mast cell disorders an overview [show details]
…population, are reviewed separately. Stem cell factor (SCF) is critical for mast cell growth, differentiation, and survival. The transmembrane receptor for SCF is KIT (encoded by the proto-oncogene kit) …
5. 組換え造血成長因子の概要introduction to recombinant hematopoietic growth factors [show details]
…two weeks . Clinical use of these agents is discussed separately. Stem cell factor (SCF), also known as Kit ligand or Steel factor , and Flt3 ligand , both interact with a variety of hematopoietic progenitor …

English Journal

In vitro transdifferentiation of human adipose tissue-derived stem cells to neural lineage cells - a stage-specific incidence.

Radhakrishnan S, Trentz OA, Reddy MS, Rela M, Kandasamy M, Sellathamby S.
Adipocyte. 2019 Dec;8(1)164-177.
The present Study investigated the intrinsic ability of adipose tissue-derived stem cells (ADSCs) and their neural transdifferentiation in a stage-specific manner. Woodbury's Chemical induction was implemented with modifications to achieve neural transdifferentiation. In Group I, ADSCs were preinduc
PMID 31033391

Comparative characterization of mesenchymal stem cells from human dental pulp and adipose tissue for bone regeneration potential.

Jin Q, Yuan K, Lin W, Niu C, Ma R, Huang Z.
Artificial cells, nanomedicine, and biotechnology. 2019 Dec;47(1)1577-1584.
Bone tissue engineering is an area of regenerative medicine that attempts to repair bone defects. Seed cells such as dental pulp stem cells (DPSCs) and adipose tissue-derived stem cells (ADSCs) are two of the most well-characterized cells for bone regeneration because their use involves few ethical
PMID 31027424

LncRNA HIF2PUT inhibited osteosarcoma stem cells proliferation, migration and invasion by regulating HIF2 expression.

Zhao D, Wang S, Chu X, Han D.
Artificial cells, nanomedicine, and biotechnology. 2019 Dec;47(1)1342-1348.
The function of lncRNAs in cancer stem cells (CSCs) remains to be elucidated. The present study aimed to investigate the regulating role of a novel lncRNA, hypoxia-inducible factor-2α (HIF-2α) promoter upstream transcript (HIF2PUT), in osteosarcoma stem cells. The expression of lncRNA HIF2PUT and
PMID 30966832

Japanese Journal

鉄過剰が造血および造血環境に与える影響

鈴木隆浩
臨床血液 56(6), 577-585, 2015
… しかし，鉄過剰マウスは骨髄移植後の血球回復が有意に遅延しており，骨髄ストローマ細胞におけるいくつかの造血支持サイトカイン(CXCL12, VCAM-1, Kit-ligand, IGF-1)の発現低下が認められた。 …
NAID 130005093083